标签归档 上海龙凤阿拉后花园

Nucleic acids are biological macromolecules, including DNA and RNA. These two kinds of molecules can be used for the prevention, diagnosis and treatment of diseases, which are nucleic acid drugs. Nucleic acid drugs include small interfering RNA(siRNA), small exciting RNA(saRNA), microRNA and messenger RNA(mRNA).

All kinds of common RNA and their functions

Source: Guotai Junan Securities Research

The appearance of small nucleic acid drugs makes it possible to actively design drug sequences to target silent disease genes. Compared with other drugs targeting proteins, small nucleic acid drugs have the advantages of short preclinical research and development cycle, rich candidate targets, high specificity, high efficiency and long-term effect.　

The candidate targets are abundant and the indications are widely distributed.　

Theoretically, any disease caused by over-expression of specific genes can be treated by small nucleic acid drugs, which provides rich candidate targets for the research and development of small nucleic acid drugs, including many targets that traditional drugs can’t become drugs.　

Simple drug design and short research and development cycle.　

Small nucleic acid drugs are the biggest benefit areas of genomics and functional genomics. The design of small nucleic acid drugs can realize the digital design of disease gene (mRNA) sequences directly, thus getting rid of the large-scale screening cycle of traditional drugs, enabling drug design to be carried out actively, and the success rate of research and development is relatively high.

　 Strong targeting specificity

Small nucleic acid drugs can regulate gene expression from the post-transcriptional level, can specifically act on the mRNA transcribed by the pathogenic gene, regulate the expression of the pathogenic gene from the upstream of the disease, and can achieve sequence specificity at the single base level, with the characteristics of "targeted" and "temporary solution". In addition, the continuous innovation of nucleic acid drug delivery system can effectively deliver nucleic acid drugs to target organs, and truly achieve targeted drug delivery.

　 Long-acting drug　

On the whole, the effective action time of small nucleic acid drugs is longer than that of traditional small molecules and protein drugs. Taking siRNA drugs as an example, when the target mRNA is degraded, the RNA-induced silencing complex (RISC) can work circularly and participate in the next degradation of the target mRNA. In addition, the continuous innovation of chemical modification technology of nucleic acid drugs, including phosphate skeleton modification, glycosyl modification and base modification, can improve the stability and half-life of nucleic acid drugs, make the drug act longer, and greatly improve the compliance of patients with treatment. The long action cycle makes small nucleic acid drugs have competitive advantages in the fields of chronic diseases such as cardiovascular diseases.

At present, the main nucleic acid drugs listed in the world are antisense nucleic acid (ASO), small interfering RNA(siRNA) and nucleic acid aptamer. In addition to nucleic acid aptamers (which may exceed 30 nucleotides), nucleic acid drugs are usually oligonucleotides composed of 12~30 nucleotides, also known as oligonucleotide drugs. In addition, miRNA, ribozyme and deoxyribozyme also show great development value in the treatment of many diseases. Nucleic acid drugs have become one of the most promising fields in biomedical research and development.　 　 　　　

　Examples of approved nucleic acid drugs

Image source: Pharmaceutical Online

Compared with the existing small molecule and antibody drugs, small nucleic acid drugs have the advantages of fast target screening, high success rate of research and development, less drug resistance, wider therapeutic field and long-term effect, and have great development potential. Small nucleic acid drugs are expected to cover more indications, so their potential market scale is very broad. It is estimated that the global sales of small nucleic acid drugs will exceed 10 billion US dollars by 2025.

At present, a total of 14 small nucleic acid drugs have been approved for marketing in the world (three drugs were delisted in the early stage), including 9 ASO drugs, 4 siRNA drugs and 1 nucleic acid aptamer. After years of development, heavy products of small nucleic acid drugs have appeared, among which Nusinersen developed by Bojian and Ionis is the first drug used to treat spinal muscular atrophy in the world, and its global sales in 2021 reached US$ 1.951 billion, which is the highest-selling small nucleic acid drug at present. Inclisiran developed by Novartis and Alnylam is a long-acting lipid-lowering drug, which only needs to be injected twice a year, opening a new chapter in the application of small nucleic acid drugs to common chronic diseases. Shengnuo medicine The company has the exclusive delivery platform of polypeptide nanoparticles (PNP) in the world, and uses it to develop innovative biopharmaceutical drugs for a variety of disease indications, including oncology, fibrotic diseases and disorders, viral infections and metabolic diseases. At present, STP705, the core product, is the first candidate drug that has achieved positive clinical results in the field of oncology.

　 Aibo biology At present, the company’s pipeline covers the fields of infectious disease prevention and tumor immunity, among which the mRNA vaccine developed for COVID-19 has entered the international multi-center phase III clinical research and obtained the drug production license.

　 Agner biology The company has independent intellectual property rights of GalPET liver targeting RNAi and lipid nanoparticles (LNP) delivery core platform technology. In March, 2022, COVID-19 mRNA vaccine developed by Agner Bio and Ruibo Bio carried out Phase II clinical trial.　

Ruibo biology Is a nucleic acid technology as the core, the company not only has a variety of chemically modified oligonucleotide drug production capacity and large-scale production base, but also can provide the whole industrial chain production and development services from plasmid manufacturing, raw materials and enzyme production, to mRNA production and LNP preparation and filling of mRNA vaccines.　

Ruibo biology China is the main pioneer of small nucleic acid technology and small nucleic acid pharmacy, and four products are in the clinical research stage. According to the unsatisfied clinical needs, the pipeline of products under research is formed around many diseases such as liver disease, cardiovascular disease, metabolism, ophthalmology and rare diseases.

　 Shenxin biology Focus on the development of preventive and therapeutic mRNA vaccines and drugs. Nearly 5000 LNP libraries have been constructed, and LNP vectors suitable for different treatment scenarios have been screened, which has created excellent conditions for the continuous research and development of mRNA product pipelines. With its leading LNP delivery technology platform, we firmly believe that biology has built research and development pipelines in four major directions: infectious diseases, rare diseases, tumor therapeutic vaccines and tumor immunotherapy enhancers.

　　CCTV News:According to Weibo released by @ Jiexiu, on August 26th, Jiexiu City successively issued the Notice of Jiexiu City on Implementing Static Management in the City, the Notice of Jiexiu City on Carrying out Preventive All-staff Nucleic Acid Detection in the City, and the Notice of Jiexiu City Public Security Bureau on Temporary Road Traffic Control.

　　According to the circular, Jiexiu City received an investigation letter from Jinzhong City, informing that the positive cases in Qingxu County and xiaodian district of Taiyuan City had an activity track in Jiexiu City. According to the current epidemic situation, in order to protect people’s life safety and health, and prevent the spread of the epidemic, the leading group for the prevention and control of pneumonia infected in novel coronavirus decided to implement static management in the city. Static management time: 13: 00 on August 26th & mdash; 24:00 on August 28th. During the period, the whole city remained silent, and it was necessary not to go out. In principle, it was necessary to stay at home. All personnel are subject to "three inspections in three days", and key personnel are subject to the original control measures.

　　According to the notice, all motor vehicles are prohibited from passing on the road during the static management period (except for epidemic prevention and control, special vehicles performing tasks), and red light control monitoring equipment is enabled at all intersections in the city, and violations of the notice will be dealt with according to law.

　　Notice of Jiexiu Municipality on Implementing Static Management in the City

　　On August 26th, 2022, at 02:00 and 3:24, our city received the investigation letter from Jinzhong City, informing that the positive cases in Qingxu County and xiaodian district of Taiyuan City had an activity track in our city. According to the current epidemic situation, in order to protect people’s life safety and health, and prevent the spread of the epidemic, the leading group for the prevention and control of pneumonia infected in novel coronavirus decided to implement static management in the city.　

　　1. Static management time: from 13: 00 on August 26th & mdash; Static management was implemented at 24:00 on August 28th. During the period, the whole city remained silent, and it was necessary not to go out. In principle, it was necessary to stay at home. All personnel are subject to "three inspections in three days", and key personnel are subject to the original control measures.

　　Two, the implementation of traffic control, railway stations, train stations, bus stations, high-speed intersections to limit the flow of people, the implementation of traffic control. The city’s guaranteed supply, production, stability and epidemic prevention vehicles pass through, and the guaranteed supply enterprises "point-to-point" pick up and drop off, and social vehicles that do not meet the requirements do not run or flow.

　　Three, in addition to the supermarket, pharmacy and medical institutions and other places, the rest of the business premises will be suspended offline business. Institutions, enterprises and institutions and various social organizations do not hold gathering activities.

　　Four, all kinds of kindergartens, off-campus training institutions to stop offline teaching, boarding schools have started, with closed conditions, the implementation of closed management, closed-loop operation. Old-age care institutions implement closed management and do not visit unless necessary. All project sites under construction in the area shall be managed in a closed way and operated in a closed loop.

　　Five, all kinds of clinics and pharmacies to suspend the "one refund and two resistance" sales. Any person with a history of living in a key epidemic-related area shall be reported to the relevant competent department immediately.

　　Six, the masses do not have to leave the city, to introduce tourists to live in hotels, guesthouses, inns, homestays in silence on the spot, in accordance with the provisions of the nucleic acid testing.

　　Seven, within the scope of regional control in-service party member to bright identity, on-the-spot active investment in epidemic prevention and control work, service community treatment and transshipment, nucleic acid sampling and publicity, living materials security, community service security, policy propaganda, emotional comfort, psychological counseling, order maintenance and other work.

　　Eight, the city to the community (village) as a unit, to co-ordinate the establishment of nucleic acid testing sampling points, in accordance with the designated time and place to carry out all the nucleic acid testing. Please actively cooperate with the general public, follow the arrangement of the street (township) and community (village) to go to the sampling point, and complete the sampling work according to the guidance of the staff. When testing, please bring your ID card and take the initiative to show the "sampling code". Please wear a mask all the time during the collection process, and keep a distance of more than 2 meters from others, without talking or gathering.

　　Nine, fever, cough and other symptoms report to the community (village) at the first time, in accordance with the relevant provisions of the epidemic prevention and control to the fever clinic, it is strictly prohibited to conceal, omit or delay the report.

　　Ten, severely punish violations of laws and regulations. At present, the city has sufficient reserves of living materials. Please do not panic, make rumors, believe in rumors or spread rumors. The public security organs will investigate the relevant responsibilities of those who refuse to cooperate, disturb the order, make rumors and create troubles, and conceal, falsely report or falsify information. 　

　　Jiexiu novel coronavirus infected pneumonia epidemic prevention and control work leading team office

　　August 26th, 2022 　 　 　

　　Notice of Jiexiu city on carrying out preventive nucleic acid testing for all employees in the city

　　In view of the current grim situation of epidemic prevention and control, in order to effectively protect people’s health and life safety, according to the research of the Municipal Leading Group for Epidemic Prevention and Control, it is decided to conduct static management of the whole city from August 26 to August 28, and carry out preventive full-time nucleic acid testing. The specific arrangements are as follows:

　　First, the static management time starts at 13:00 on August 26th, 2022. During the static management period, the people in the whole city will stay at home, so as to "stay inside, stay outside, and stay inside". In principle, they must stay at home.

　　Second, the sampling range and requirements

　　1. Take the village and community as the unit and the grid as the smallest unit, set up nucleic acid sampling points as a whole, and carry out all-staff nucleic acid testing at the designated time and place. In order to complete the nucleic acid detection as soon as possible, residents are requested to actively cooperate, follow the arrangement of the village and the community, go to the sampling point, bring their resident ID cards, and log in to WeChat "Jinzhong Nucleic Acid Detection Terminal" in advance to generate a sampling code (screen capture can be saved, or a paper version can be printed in advance).

　　2. Please wear a mask throughout the collection process, keep a distance of more than 2 meters from others, and return immediately without talking or gathering.

　　3. Those who have not been vaccinated with Covid-19 vaccine for more than 48 hours will not participate in the full-time nucleic acid test after reporting to the community (village) where they live.

　　Third, matters needing attention

　　1. During the whole staff nucleic acid test, temporary traffic control will be implemented in the whole city. Except for special vehicles such as police cars, fire engines, ambulances, garbage trucks and material support vehicles, other social vehicles are not allowed to drive on the road. Only three high-speed exits, train stations, railway stations and Sanxian Avenue are reserved in the referral channel, and the original mechanism and process are maintained to work normally, so that the referral personnel can collect nucleic acids on the spot. In principle, you can’t get in or out, and the rest of the staff are strictly in a static state at their current residence, and they don’t flow at home. 　　

　　2. Except for large factories, mines and enterprises related to people’s livelihood security and production safety, other enterprises suspend production; Restaurants, entertainment and other business stores are closed. Departments in charge of various industries should promptly notify enterprises and business premises in various industries, and enterprises should make early preparations and make reasonable adjustments to the transportation of goods within the specified time and region. The necessary personnel on duty in the unit and the personnel maintaining the operation of the enterprise should ensure that they arrive at their posts or stay at home before the start of the static management period, and other personnel stay at home and wait for arrangements. The relevant units and industry authorities are responsible for the normal staff, and the list of personnel and vehicles should be reported to the Municipal Prevention and Control Office in advance. After the summary, the Municipal Prevention and Control Office will report to the public security traffic police and issue passes.

　　3. Teachers, students and employees in closed management schools shall be isolated and controlled centrally, and people with disabilities, bedridden and other mobility difficulties shall be arranged to conduct on-site nucleic acid sampling in a unified manner.

　　4. Residents and friends who have symptoms such as fever and cough, please don’t go to the sampling point, report to the local community in time, and on the basis of personal protection, go to the fever clinic of the People’s Hospital for treatment and collect nucleic acid.

　　5. If there are special circumstances such as critically ill patients seeking medical treatment and pregnant women giving birth, please call 120 emergency number in time.

　　6. This full-time nucleic acid test is a preventive test and a concrete measure to implement the requirements of "four mornings". Please actively cooperate with the urban and rural residents, and do not panic, spread rumors, believe in rumors, spread rumors, or stay and watch.

　　7. Please take the initiative to participate in the inspection, otherwise it will affect the decoding and transcoding of personal "red code" and "yellow code" in the later period.

　　8. For residents who do not participate in the full-scale nucleic acid test without justifiable reasons, I will bear corresponding legal responsibilities in accordance with the Law of People’s Republic of China (PRC) on the Prevention and Control of Infectious Diseases and other relevant regulations. Those who refuse to cooperate, do not support the nucleic acid detection work, disturb the order, conceal, lie or falsify information will be strictly investigated for legal responsibility according to law.

　　Safe rest, thank you. Sincerely thank the residents and friends for their understanding, support and cooperation!

　　Jiexiu COVID-19 epidemic prevention and control work leading team office

　　August 26th, 2022 　　

　　Notice of Jiexiu Public Security Bureau on Temporary Road Traffic Control

　　The general public and driver friends:

　　According to the requirements of the epidemic prevention and control leading office of COVID-19 City, Jiexiu City, from 13: 00 on August 26th, 2022 to 24: 00 on August 28th, 2022, the whole city will implement temporary global static management. During the static management period, all motor vehicles will be prohibited from passing on the road (except special vehicles for epidemic prevention and control and performing tasks). At the same time, all intersections in the city will be enabled with red light control and monitoring equipment, and violations of this notice will be dealt with according to law.

　　notice is hereby given (that)

　　Jiexiu bureau of public security

　　August 26th, 2022

　　Zhongxin Jingwei Client September 26th (Liu Xueyu) Following the "9.30" property market new policy, a new round of "regulation tide" has been set off nationwide since September 22nd. Within four days, nine cities including Chongqing, Nanchang, Xi ‘an and Wuxi intensively issued purchase restriction policies. What is different from the past is that the regulatory content introduced in many places across the country is mainly "restricted sales". Insiders pointed out that this also means that the regulation of new hot cities will not be relaxed for a long time. In addition, the national provident fund loan policy may be further tightened.

　　9 cities introduce new real estate policies within 4 days.

　　In just four days, nine cities including Re, Nanchang, Xi ‘an and Shijiazhuang introduced the purchase restriction policy. Among them, it is noteworthy that Wuxi has issued an "enhanced version" of the purchase restriction order, requiring local people to ban the purchase of the third set of new commercial housing in different regions; Foreigners are restricted to buy a house and need to pay social security in tin for 2 years; The second use of provident fund loans, the down payment ratio is not less than 40%.

　　"Wuxi’s New Deal has adjusted the provident fund loan policy, which is a very strong signal." Yan Yuejin, research director of think tank center of Yiju Research Institute, told Zhongxin Jingwei client that at present, commercial banks in many parts of the country have begun to tighten their loan policies. In the new policy issued by Wuxi property market, the tightening of provident fund loans means that the provident fund loan policies in many parts of the country have also been further tightened.

　　Regulating urban housing price increases ranks high.

　　At the same time, Yang Hongxu, vice president of Yiju Research Institute, said in an interview with Zhongxin Jingwei client that Wuxi originally only restricted the new housing market, and this new policy restricted the second-hand housing market. "The reason why Wuxi released the new property market policy may be that Wuxi’s housing prices rose significantly in August."

　　"Most cities that have intensively released regulatory policies in many places across the country are cities with the highest price increase." Zhang Dawei, chief analyst of Zhongyuan Real Estate, summed up the clients of Sino-Singapore Jingwei. For example, Nanchang, Xi ‘an, Changsha and Guiyang were among the top cities in the statistics of residential sales prices in 70 large and medium-sized cities released by the National Bureau of Statistics in August.

　　"The targets of this round of regulation are all provincial capitals (or municipalities directly under the Central Government), which is a hot city with a new round of rising house prices and rising transaction volume in the near future." Yang Xianling, president of Chain Home Research Institute, analyzed with the client of Zhongxin Jingwei that these regulated cities are still future cities with net population inflow, and the pressure of rising house prices exists objectively to some extent, and the regulation is also in line with the routine.

　　"restricted sales" will lead to a short-term cooling of the market

　　In addition, the Zhongxin Jingwei client noticed that since September 22, the new policies issued by the national property market are mainly based on the "restricted sales" policy. For example, Nanning’s New Deal requires that the purchase of second and above new houses and second-hand houses be restricted for two years; Nanchang New Deal requires that all indoor new houses and second-hand houses be restricted for 2 years.

　　Why are the new policies introduced in various places related to "restricted sales"? What impact will "restricted sales" bring? Yang Xianling said that the multi-site control policy is mainly based on "restricted sales", which can cool down the real estate market in a short period of time. However, if we want to achieve results in the long term, we still need a long-term mechanism to stabilize the real estate market for a long time.

　　Yang Xianling said that this round of regulation is a new round after the "September 30th" New Deal last year and the "March 17th" New Deal this year. The regulation of new hot cities will not be relaxed for a long time, and the government’s determination to curb housing prices will not change.

　　In the future, other cities will continue to follow up and regulate.

　　This year, more than 100 cities across the country introduced a new property market policy.

　　According to the statistics provided by the Central Plains Real Estate Research Center to the Sino-Singapore Jingwei client, so far this year, more than 100 cities (above the county level) have issued more than 150 measures related to real estate regulation. In Beijing alone, more than 20 new policies have been issued. At the same time, 15 hot cities across the country have issued more than four real estate control policies.

　　Zhang Dawei said that this year’s real estate regulation and control policy has fundamentally changed from previous years. In the past, the policy regulation and control was "ex post facto control", but this year’s real estate regulation and control was more "expected control". On the premise of no unstable factors in the real estate market, the new policy was released in advance, which was more effective than the real estate regulation and control measures in previous years.