分类归档 hfjfgff

　　CCTV News:According to Weibo released by @ Jiexiu, on August 26th, Jiexiu City successively issued the Notice of Jiexiu City on Implementing Static Management in the City, the Notice of Jiexiu City on Carrying out Preventive All-staff Nucleic Acid Detection in the City, and the Notice of Jiexiu City Public Security Bureau on Temporary Road Traffic Control.

　　According to the circular, Jiexiu City received an investigation letter from Jinzhong City, informing that the positive cases in Qingxu County and xiaodian district of Taiyuan City had an activity track in Jiexiu City. According to the current epidemic situation, in order to protect people’s life safety and health, and prevent the spread of the epidemic, the leading group for the prevention and control of pneumonia infected in novel coronavirus decided to implement static management in the city. Static management time: 13: 00 on August 26th & mdash; 24:00 on August 28th. During the period, the whole city remained silent, and it was necessary not to go out. In principle, it was necessary to stay at home. All personnel are subject to "three inspections in three days", and key personnel are subject to the original control measures.

　　According to the notice, all motor vehicles are prohibited from passing on the road during the static management period (except for epidemic prevention and control, special vehicles performing tasks), and red light control monitoring equipment is enabled at all intersections in the city, and violations of the notice will be dealt with according to law.

　　Notice of Jiexiu Municipality on Implementing Static Management in the City

　　On August 26th, 2022, at 02:00 and 3:24, our city received the investigation letter from Jinzhong City, informing that the positive cases in Qingxu County and xiaodian district of Taiyuan City had an activity track in our city. According to the current epidemic situation, in order to protect people’s life safety and health, and prevent the spread of the epidemic, the leading group for the prevention and control of pneumonia infected in novel coronavirus decided to implement static management in the city.　

　　1. Static management time: from 13: 00 on August 26th & mdash; Static management was implemented at 24:00 on August 28th. During the period, the whole city remained silent, and it was necessary not to go out. In principle, it was necessary to stay at home. All personnel are subject to "three inspections in three days", and key personnel are subject to the original control measures.

　　Two, the implementation of traffic control, railway stations, train stations, bus stations, high-speed intersections to limit the flow of people, the implementation of traffic control. The city’s guaranteed supply, production, stability and epidemic prevention vehicles pass through, and the guaranteed supply enterprises "point-to-point" pick up and drop off, and social vehicles that do not meet the requirements do not run or flow.

　　Three, in addition to the supermarket, pharmacy and medical institutions and other places, the rest of the business premises will be suspended offline business. Institutions, enterprises and institutions and various social organizations do not hold gathering activities.

　　Four, all kinds of kindergartens, off-campus training institutions to stop offline teaching, boarding schools have started, with closed conditions, the implementation of closed management, closed-loop operation. Old-age care institutions implement closed management and do not visit unless necessary. All project sites under construction in the area shall be managed in a closed way and operated in a closed loop.

　　Five, all kinds of clinics and pharmacies to suspend the "one refund and two resistance" sales. Any person with a history of living in a key epidemic-related area shall be reported to the relevant competent department immediately.

　　Six, the masses do not have to leave the city, to introduce tourists to live in hotels, guesthouses, inns, homestays in silence on the spot, in accordance with the provisions of the nucleic acid testing.

　　Seven, within the scope of regional control in-service party member to bright identity, on-the-spot active investment in epidemic prevention and control work, service community treatment and transshipment, nucleic acid sampling and publicity, living materials security, community service security, policy propaganda, emotional comfort, psychological counseling, order maintenance and other work.

　　Eight, the city to the community (village) as a unit, to co-ordinate the establishment of nucleic acid testing sampling points, in accordance with the designated time and place to carry out all the nucleic acid testing. Please actively cooperate with the general public, follow the arrangement of the street (township) and community (village) to go to the sampling point, and complete the sampling work according to the guidance of the staff. When testing, please bring your ID card and take the initiative to show the "sampling code". Please wear a mask all the time during the collection process, and keep a distance of more than 2 meters from others, without talking or gathering.

　　Nine, fever, cough and other symptoms report to the community (village) at the first time, in accordance with the relevant provisions of the epidemic prevention and control to the fever clinic, it is strictly prohibited to conceal, omit or delay the report.

　　Ten, severely punish violations of laws and regulations. At present, the city has sufficient reserves of living materials. Please do not panic, make rumors, believe in rumors or spread rumors. The public security organs will investigate the relevant responsibilities of those who refuse to cooperate, disturb the order, make rumors and create troubles, and conceal, falsely report or falsify information. 　

　　Jiexiu novel coronavirus infected pneumonia epidemic prevention and control work leading team office

　　August 26th, 2022 　 　 　

　　Notice of Jiexiu city on carrying out preventive nucleic acid testing for all employees in the city

　　In view of the current grim situation of epidemic prevention and control, in order to effectively protect people’s health and life safety, according to the research of the Municipal Leading Group for Epidemic Prevention and Control, it is decided to conduct static management of the whole city from August 26 to August 28, and carry out preventive full-time nucleic acid testing. The specific arrangements are as follows:

　　First, the static management time starts at 13:00 on August 26th, 2022. During the static management period, the people in the whole city will stay at home, so as to "stay inside, stay outside, and stay inside". In principle, they must stay at home.

　　Second, the sampling range and requirements

　　1. Take the village and community as the unit and the grid as the smallest unit, set up nucleic acid sampling points as a whole, and carry out all-staff nucleic acid testing at the designated time and place. In order to complete the nucleic acid detection as soon as possible, residents are requested to actively cooperate, follow the arrangement of the village and the community, go to the sampling point, bring their resident ID cards, and log in to WeChat "Jinzhong Nucleic Acid Detection Terminal" in advance to generate a sampling code (screen capture can be saved, or a paper version can be printed in advance).

　　2. Please wear a mask throughout the collection process, keep a distance of more than 2 meters from others, and return immediately without talking or gathering.

　　3. Those who have not been vaccinated with Covid-19 vaccine for more than 48 hours will not participate in the full-time nucleic acid test after reporting to the community (village) where they live.

　　Third, matters needing attention

　　1. During the whole staff nucleic acid test, temporary traffic control will be implemented in the whole city. Except for special vehicles such as police cars, fire engines, ambulances, garbage trucks and material support vehicles, other social vehicles are not allowed to drive on the road. Only three high-speed exits, train stations, railway stations and Sanxian Avenue are reserved in the referral channel, and the original mechanism and process are maintained to work normally, so that the referral personnel can collect nucleic acids on the spot. In principle, you can’t get in or out, and the rest of the staff are strictly in a static state at their current residence, and they don’t flow at home. 　　

　　2. Except for large factories, mines and enterprises related to people’s livelihood security and production safety, other enterprises suspend production; Restaurants, entertainment and other business stores are closed. Departments in charge of various industries should promptly notify enterprises and business premises in various industries, and enterprises should make early preparations and make reasonable adjustments to the transportation of goods within the specified time and region. The necessary personnel on duty in the unit and the personnel maintaining the operation of the enterprise should ensure that they arrive at their posts or stay at home before the start of the static management period, and other personnel stay at home and wait for arrangements. The relevant units and industry authorities are responsible for the normal staff, and the list of personnel and vehicles should be reported to the Municipal Prevention and Control Office in advance. After the summary, the Municipal Prevention and Control Office will report to the public security traffic police and issue passes.

　　3. Teachers, students and employees in closed management schools shall be isolated and controlled centrally, and people with disabilities, bedridden and other mobility difficulties shall be arranged to conduct on-site nucleic acid sampling in a unified manner.

　　4. Residents and friends who have symptoms such as fever and cough, please don’t go to the sampling point, report to the local community in time, and on the basis of personal protection, go to the fever clinic of the People’s Hospital for treatment and collect nucleic acid.

　　5. If there are special circumstances such as critically ill patients seeking medical treatment and pregnant women giving birth, please call 120 emergency number in time.

　　6. This full-time nucleic acid test is a preventive test and a concrete measure to implement the requirements of "four mornings". Please actively cooperate with the urban and rural residents, and do not panic, spread rumors, believe in rumors, spread rumors, or stay and watch.

　　7. Please take the initiative to participate in the inspection, otherwise it will affect the decoding and transcoding of personal "red code" and "yellow code" in the later period.

　　8. For residents who do not participate in the full-scale nucleic acid test without justifiable reasons, I will bear corresponding legal responsibilities in accordance with the Law of People’s Republic of China (PRC) on the Prevention and Control of Infectious Diseases and other relevant regulations. Those who refuse to cooperate, do not support the nucleic acid detection work, disturb the order, conceal, lie or falsify information will be strictly investigated for legal responsibility according to law.

　　Safe rest, thank you. Sincerely thank the residents and friends for their understanding, support and cooperation!

　　Jiexiu COVID-19 epidemic prevention and control work leading team office

　　August 26th, 2022 　　

　　Notice of Jiexiu Public Security Bureau on Temporary Road Traffic Control

　　The general public and driver friends:

　　According to the requirements of the epidemic prevention and control leading office of COVID-19 City, Jiexiu City, from 13: 00 on August 26th, 2022 to 24: 00 on August 28th, 2022, the whole city will implement temporary global static management. During the static management period, all motor vehicles will be prohibited from passing on the road (except special vehicles for epidemic prevention and control and performing tasks). At the same time, all intersections in the city will be enabled with red light control and monitoring equipment, and violations of this notice will be dealt with according to law.

　　notice is hereby given (that)

　　Jiexiu bureau of public security

　　August 26th, 2022

The patent dispute was once again staged between Xiaomi Group and Huawei. On December 12, Xiaomi Group issued a statement saying that recently,Mr. Yu Chengdong made false statements against the company’s "keel shaft" technology for no reason, which was seriously inconsistent with the facts.

The dispute stems from the speech made by Yu Chengdong, managing director of Huawei, CEO of terminal BG and chairman of BU, a smart car solution, at the Huawei Pollen Annual Meeting in 2023: "Don’t respect us very much.(Huawei)Intellectual property rights, take it and just make up a name and say your own. Double-rotating water drop hinge directly becomes keel hinge, and keel does not exist. "　

It is worth noting that both the "double-rotating water drop hinge" and the "keel hinge" are the key components of the folding screen mobile phone, which is the key to determine the completion of the folding screen mobile phone product. In the context of sluggish demand in the terminal market, the "dark horse" of folding screen mobile phones has a considerable market in the future. Moving towards folding screens has become a tacit strategic direction for mobile phone manufacturers.

First, Xiaomi Group publicly clarified

At noon on December 12th, the reporter of national business daily learned from Xiaomi Group that the spokesman of Xiaomi Company released a clarification message through Weibo, saying that recently, Mr. Yu Chengdong made false remarks against the company’s "keel shaft" technology for no reason, which was seriously inconsistent with the facts. Please ask Mr. Yu Chengdong to follow the basic rules of "science and rigor" and stop discrediting his peers and misleading the public.

Image source: Sina Weibo

This "war" originated from the speech made by Yu Chengdong, managing director of Huawei, CEO of BG and chairman of BU, a smart car solution, at the 2023 annual pollen conference. At that time, he once "bombarded" friends and merchants for plagiarism: "Don’t respect us very much.(Huawei)Intellectual property rights, take it and just make up a name and say your own. Double-rotating water drop hinge directly becomes keel hinge, and keel does not exist. "　

This remark attracted Xiaomi’s "return".

According to Xiaomi Group, the "keel shaft" is a new generation of folding shaft developed by Xiaomi Group, and it is the first three-level rod group structure in the industry. No matter the design idea or the mechanical structure, the "keel shaft" is completely different from the "double-rotating water drop hinge" declared by Mr. Yu Chengdong.

Xiaomi said that after studying the technical information and published patent information disseminated by Mr. Yu Chengdong’s company, and after actual disassembly and verification, the "double-rotating water drop hinge" adopts the design scheme of "2-level rod group, 3 components and 4 low pairs"; The mechanical structure of Xiaomi’s self-developed "keel shaft" adopts the innovative design of "3-level rod group, 5 components and 7 low pairs".

At the same time, Xiaomi also took a number of screenshots in the social media comment area, saying that the company’s self-developed "keel shaft" applied for a patent on September 18, 2020 and was granted a patent on January 5, 2021; August, 2023 in Xiaomi MIX Fold.(Mobile phone model)On the first application. The "double-rotating water drop hinge" claimed by Mr. Yu Chengdong applied for a patent on December 13th, 2019 and was published on June 18th, 2021. Yu Chengdong’s company’s patent application for the three-level bar group was filed on October 29th, 2021 and made public on May 5th, 2023. So far, there is no information to confirm the authorization, and it has not been commercialized.

Judging from the attitude of Xiaomi Group, this response can be described as sharp: "Please ask Mr. Yu Chengdong to follow the basic rules of’ science and rigor’, and don’t discredit his peers and mislead the public."

As of press time, Huawei has not responded to the above statement of Xiaomi Group.

Second, the patent dispute between the two parties is not the first time.

In the face of this "Mihua patent dispute", many netizens expressed their opinions in the comment area.

National business daily reporter noticed that many netizens talked about the different types of patents involved in Xiaomi and Huawei. According to the information disclosed by Xiaomi, the patent type of the company’s "hinge, display module and terminal equipment" is "utility model"; Huawei’s patent type of "folding mechanism and folding electronic equipment" is "invention application".

Some netizens’ opinions Image source: social media screenshot　

However, some netizens pointed out that,Xiaomi’s patent for "hinge, display module and terminal equipment" also involves "double application in one case" when applying.

According to the analysis of a person in the industry who did not want to be named, the above case of Xiaomi may involve "double application in one case". Paragraph 1 of Article 9 of the current Patent Law stipulates: "Only one patent right can be granted for the same invention-creation. However, if the same applicant applies for both a patent for utility model and an invention patent for the same invention-creation on the same day, and the patent right for utility model obtained first has not been terminated, and the applicant declares to give up the patent right for utility model, the invention patent right may be granted. "

According to public information, the "keel hinge" technology is used on Xiaomi’s flagship folding screen mobile phone Xiaomi MIX Fold 3 released this year. Lei Jun, chairman of Xiaomi, once said that Xiaomi keel shaft contains 198 parts, 14 movable joints and 3-level linkage structure, which can provide better screen protection while realizing thinness.

Xiaomi MIX Fold 3 (right) Image source: Xiaomi official website screenshot

The "double rotating water drop hinge" was first proposed by Huawei in 2021. At that time, Yu Chengdong said at the press conference that Huawei’s water drop hinge is an exclusive patent, and other companies must use Huawei’s patented technology if they want to realize seamless folding screen.

Huawei Mate-x folding screen mobile phone Image source: national business daily (data map)　

It is worth mentioning that,This is not the first time that Huawei and Xiaomi have had differences on intellectual property issues.On January 17th this year, China National Intellectual Property Administration accepted the patent infringement case brought by Huawei, the claimant, against Xiaomi. Judging from the contents of the patents, the above four patents involved in disputes are respectively: method and device for sending control signaling, method for feeding back ACK/NACK information during carrier aggregation, base station and user equipment, method and terminal for acquiring panoramic images, screen locking method and mobile terminal.

On March 1, Xiaomi responded: "The two sides are actively negotiating on patent licensing." Since then, Xiaomi has successively initiated requests for invalidation of four patents involved in Huawei’s case, and China National Intellectual Property Administration conducted oral trials after accepting them. In September this year, China National Intellectual Property Administration declared that "the patent right will remain valid".

On September 13th this year, Huawei and Xiaomi announced a global patent cross-licensing agreement, which covers communication technologies including 5G. When talking about whether the signing of the new agreement will affect the previous patent disputes, Xiaomi Group once responded exclusively to the reporter of national business daily: "The previous legal procedures will be resolved according to this agreement."

By the end of 2022, Huawei had more than 120,000 valid authorized patents in the world, and was in a leading position in many mainstream standard patent fields such as mobile communication, short-range communication and codec. In 2022, Huawei’s patent licensing revenue was about 560 million US dollars.

Third, the competition for folding screen mobile phones is becoming increasingly fierce.

Both the "double-rotating water drop hinge" and the "keel hinge" are key components of the folding screen mobile phone:It is an important mechanical "joint" to support the flexible screen, control the rotation range and realize the shape change of the mobile phone; At the same time, it is also the key to determine the completion of folding screen mobile phone products, which tests the technical accumulation of major mobile phone manufacturers.

In this context, the "dark horse" of folding screen mobile phones has become a cluster of flames in the winter of mobile phone consumption. From the appearance, the innovative and personalized appearance of the folding screen mobile phone relieves consumers’ aesthetic fatigue of the traditional straight mobile phone; Different folding methods, such as left and right folding, up and down folding, internal folding and external folding, also bring new experiences to consumers.

According to Counterpoint’s forecast, the shipment of folding screen mobile phones in China will exceed 5 million units in 2023, and it is expected to explode in 2024, reaching 10 million units. In 2025, the folding screen market in China will reach 17 million units. Omdia predicts that by 2026, the global shipment of folding screen smartphones will reach 61 million units, with a compound annual growth rate of 46.6% from 2021 to 2026.

In the face of the rare incremental market, almost all major mobile phone brands except Apple have entered the folding track.Going to the folding screen has become a tacit strategy for mobile phone manufacturers, especially those who compete for high-end share.

As for the current market share of each company, the report released by IDC, an international data company, shows that the market shipment of folding screen mobile phones in China reached 1.96 million units in the third quarter, up 90.4% year-on-year.

In terms of manufacturers, Huawei ranked first in the market share in the first three quarters of this year, reaching 31.7%; OPPO ranked second with a share of 17.9%; Samsung ranked third, accounting for 15.4% of the market; Glory gained 15.1% market share, ranking fourth; Vivo ranked fifth, with a share of 12.7%, and X Flip continued to sell well for half a year. Xiaomi’s market share is 5.2%, and the first sale of MIX Fold3 is obviously better than that of the previous generation.

This article comes from WeChat WeChat official account:Headline of each warp (ID: nbdtoutiao)Author: Yang Hui, Jing Wong, Editor: Cheng Peng, Zhang Haini, Du Hengfeng.

Geely Automobile has recently announced that it has made a privatization offer to the board of directors of Krypton, and plans to buy back the tradable shares at a price of 11.5 US dollars per share. Krypton will delist from the NYSE and return to the Geely system.

After delisting, Krypton will share the R&D resources of SEA’s vast architecture with brands such as Geely Galaxy and Lotus. Geely insiders revealed that the high-performance electric drive technology of Krypton 001 FR will be decentralized to the Galaxy series, and the intelligent cockpit system of Galaxy will also feed back the Krypton model. In terms of sales channels, Krypton direct stores will gradually merge into Geely’s "4S+ Shangchao" mixed network, and it is estimated that the channel cost will be saved by over 1.5 billion yuan every year.

The deep logic of this integration lies in responding to changes in the industry. After returning to the Group, Krypton can rely on Geely’s supply chain advantages to reduce costs, and the capacity utilization rate of its Ningbo factory is expected to be improved.

Xinhua News Agency, Beijing, March 5th Title: 3%: Stabilizing prices means stabilizing people’s livelihood.

Xinhua News Agency reporter Wei Yukun

Prices are related to economic operation and affect people’s lives. This year’s government work report sets the annual consumer price increase at around 3%. This expected goal fully considers various potential factors affecting prices, leaving some room, which is conducive to stabilizing market expectations and enhancing the determination and confidence in doing a good job in ensuring supply and stabilizing prices.

Compared with the situation of high global inflation, the price increase is set at around 3%, which is particularly rare. The price increase is controlled at a relatively stable level for a long time, leaving enough room for macro-policy regulation and control, which can effectively support the economic operation to maintain a reasonable range. Since last year, China has accurately grasped the policy to ensure supply and stabilize prices, and prices have always been running in a reasonable range, which has played an important role in stabilizing the economic market. In January this year, domestic prices maintained a stable operation, and CPI rose by 2.1% year-on-year, significantly lower than the increase of 6.4% in the United States and 10.1% in the United Kingdom, and continued to be an important "stabilizer" for global prices.

Affected by imported inflation, hikes and other factors, the pressure of rising prices still exists this year, but from the perspective of supply fundamentals, China’s prices have a solid foundation for maintaining a stable operation. The continuous bumper harvest of grain production, the project of improving soybean oil production capacity started well, the pig production capacity was reasonable and abundant, the vegetable production in the field area and aquatic products increased steadily, the industrial and service markets were adequately supplied, the basic energy supply was strong, and the system of ensuring supply and stabilizing prices was further improved. Since the beginning of the year, all localities and departments have actively implemented the central government’s arrangements and made overall plans to ensure stable supply and prices. For example, the Ministry of Agriculture and Rural Affairs launched a large-scale training on field management techniques in spring to ensure stable production and increase production of grain and oil; Ningxia, Anhui and other places have strengthened market price monitoring, analysis and early warning, etc., to ensure that the supply of important people’s livelihood commodities is sufficient, the reserves are substantial, and the market prices are stable and orderly.

Under the condition of market economy, prices are greatly influenced by the relationship between supply and demand, and sometimes there will be some fluctuations. China has a strong economic resilience, a large market space and a rich policy toolbox. It insists on implementing a prudent monetary policy, scientifically grasps the strength, rhythm and key points of the policy, and does not engage in "flood irrigation". It has a relatively complete control system, rich practical experience and the ability to effectively cope with abnormal market price fluctuations.

The price increase of 3% is not simple. Adhere to the people-centered, improve the ability and level of price control, ensure price stability with stable supply, and promote supply stability with stable price. We are fully qualified, capable and confident to maintain overall price stability.

　　CCTV News:The Central Meteorological Observatory continued to issue a typhoon red warning at 18: 00 on September 1:

　　The center of Typhoon Sura No.9 this year (super typhoon level) is located at 5 o’clock in the afternoon today (September 1) in the northeastern South China Sea, about 110 kilometers south-east of Hong Kong, that is, 22.0 degrees north latitude and 115.1 degrees east longitude. The maximum wind force near the center is 17 (58 meters per second), the lowest pressure in the center is 925 hectopascals, and the radius of the seven-level wind circle is 250-280 kilometers.

　　It is estimated that "Sura" will move from north to west at a speed of 10-15 kilometers per hour, and its intensity will slowly weaken. It will land or brush the coast from Taishan to Shenzhen in Guangdong in the early morning of September 2 (strong typhoon level, 42-50 m/s, 14-15), and then move to the south-west direction.

　　In addition, the center of the 11th typhoon "HAIKUI" this year is located at 5 o’clock in the afternoon today (September 1st) in the northwest Pacific Ocean about 770 kilometers south-east of Taipei City, Taiwan Province Province, which is 22.4 degrees north latitude and 128.5 degrees east longitude. The maximum wind force near the center is 12 (33m/s), and the lowest pressure in the center is 975 hectopascals, with a seven-level wind circle.

　　It is estimated that "Anemone" will move westward at a speed of 15-20km/h, and its intensity will gradually increase, with the strongest typhoon level (42-45m/s, level 14). It will land on the eastern coast of Taiwan Province Island around the evening of the 3rd, then pass through Taiwan Province Island and gradually approach the coast of Fujian.

　　Gale forecast:From 20: 00 on September 1 to 20: 00 on September 2, affected by Sura, the Taiwan Province Strait, the central and southern South China Sea, the waters near Nansha Islands, zhongsha islands and Huangyan Island, and the coastal areas of Zhejiang will have 6-7 grades and gusts of 8-9 winds; There will be strong winds of 7-9 grades and gusts of 10-11 grades in the northwest of the South China Sea, Fujian coastal areas, Guangdong coastal areas, the Pearl River Estuary, Hong Kong and Macao, etc., and there will be strong winds of 10-12 grades in some of the above sea areas or areas, and the winds in the nearby seas or areas passing by the "Sura" center will be 13-17 grades and gusts of 17 or above; Affected by Anemone, there are 6-7 grades in the south and east of the East China Sea and east of Taiwan Province, 8-10 grades in some sea areas, and 11-12 winds in gusts.

　　Precipitation forecast: From 20: 00 on September 1 to 20: 00 on September 2, due to the influence of Sura, there were heavy rains in southeastern Fujian, central and southern Guangdong, Hong Kong and Macao, among which there were heavy rains in parts of southern Guangdong, Hong Kong and Macao, and local heavy rains (250-280 mm).

　　Defense guide:

　　1. The government and relevant departments shall, in accordance with their duties, do a good job in typhoon prevention and emergency rescue.

　　2. Water operations and passing ships in relevant waters should return to Hong Kong to take shelter from the wind, strengthen port facilities, and prevent ships from anchoring, grounding and collision.

　　3. Stop large-scale indoor and outdoor gatherings and dangerous outdoor operations such as high altitude.

　　4. Reinforce or dismantle structures that are easy to be blown by the wind. Personnel should not go out at will. They should stay in windproof and safe places as far as possible, so as to ensure that the elderly and children stay in the safest place at home, and the dangerous people will be transferred in time. When the typhoon center passes by, the wind will decrease or stay still for a period of time. Remember that the strong wind will suddenly blow and you should continue to stay in a safe place to avoid the wind.

　　5. Relevant areas should pay attention to prevent flash floods and geological disasters that may be caused by heavy precipitation.

comeSource | Yaozhi. com(Reprinted by Cybertron)

Write | 　 three 　

Up to the seventh batch, Hengrui Pharma has won the bid for 20 varieties. During this period, however, the market value continued to be under pressure. Although there are many reasons for losing the bid, it is not that winning the bid can unilaterally bring different profits to the enterprise.

The answer is obvious.

Centralized purchasing is a hurdle that Hengrui can’t cross, and the same is true for the entire pharmaceutical industry. Nowadays, Hengrui innovative drugs are developing rapidly, and a large amount of R&D investment is made every year. Under the guidance of innovative drugs, Hengrui’s short-term pain at present may be just preparing for the bright future.

But is this really the case?

Looking back on the situation in the national medical insurance talks last year, the price of Karelizumab of Hengrui decreased by 85% and that of Esketamine decreased by 68%, but it failed to achieve the expected effect of "exchanging price for quantity". In the end, due to various factors, the sales volume of the product fell short of expectations, and the overall performance declined seriously in 2021. Even in the first quarter of this year, there was no sign of stopping the decline, and 20.93% of the performance decreased year-on-year, which was "Du Jie".

From this point of view, in today’s pharmaceutical market, it is not just generic drugs that are not easy to do, and the situation of innovative drugs is also not optimistic.

Last month, the National Medical Insurance Bureau officially announced the Work Plan for the Adjustment of the National Basic Medical Insurance, Work Injury Insurance and Maternity Insurance Drug List in 2022 and related documents. Hengrui has not recovered from the last shock, but the fifth round of the adjustment of the national medical insurance drug list will begin again.

This time, for Hengrui, is it a turning point, or is it worse?

01

Hengrui 3 new drugs, medical insurance is the only way out?

According to relevant reports, from July 1 last year to June 30 this year, there were about 31 innovative drugs (excluding newly approved indications for listed drugs) approved by domestic enterprises for the first time, including monoclonal antibodies, double antibodies, CAR-T and other drug types, covering many diseases such as cancer and immunity.

Among them, Hengrui has three new drugs that try to advance into the medical insurance catalogue this year, namely, Darceli, Hengglinide and Riverumide.

Heng ge lie Jing

First of all, as two new drugs approved by Hengrui on the same day, both Hengglinide and Darcyril are the first domestic innovative drugs in their respective targets.

The former, Henggliclazide, is also the first SGLT-2 1 new drug independently developed in China, which marks a major breakthrough in the field of treatment in China, and what is more important, of course, is to break the monopoly of foreign companies in the original research of SGLT-2 inhibitors for many years.

According to relevant data, up to now, five SGLT-2 inhibitors have been approved for listing in the domestic hypoglycemic drug market (including compound preparations). Because the approval time of Hengglinide is shorter than that of its predecessors, this has become its most important fatal factor. At present, the market is not fully opened, so it may be even more urgent to superimpose the medical insurance volume in this national medical insurance talk.

In addition, except for the generic drugs of Agglinide tablets in the above table, the other four SGLT-2 inhibitor competing products of Hengrui have been approved to be listed and regarded as over-evaluated, among which both Kagglinide and Engelglinide were included in the fourth batch of centralized purchase. Due to the late listing, the impact of overlapping centralized purchase did not fully appear, and the sales growth rate of the two products in China public medical institutions in 2021 still exceeded 500% and 200%.

Finally, although there are no other SGLT-2 inhibitor Class 1 new drugs approved in China except Hengrui Henggliclazide, the related products of Dongyang Guangyao, Xuanzhu Medicine and other enterprises have also entered Phase III clinical trials, and it is expected that more enterprises will join the competition pattern in the later period. It can be said that this year’s national health insurance talk has become the only hope of Hengrui, a new drug that has not been listed for one year.

Darsili 　　

The situation of another new drug, Dalxil, is also not weaker than that of Hengglinide. According to relevant data, before the approval of Darcyril Tablets, there were four CDK4/6 inhibitors on the global market. Except Trilaciclib, which was approved for bone marrow suppression, the other three inhibitors (Piperacil from Pfizer, Rebocili from Novartis and Agbesi from Lilly) were all used to treat HR+/HER2- breast cancer.

In last year’s national talks on medical insurance, Lilly negotiated successfully before Pfizer, and Abeceli became the first CDK4/6 inhibitor to enter the medical insurance catalogue, which was officially implemented on January 1, 2022. This year, in addition to Abeceli’s soon-approved auxiliary indications, it is highly probable that he will strive to enter the medical insurance list, and the remaining Pipeceli and Rebosi are expected to make many moves in this national talk. At the same time, CDK4/6 is the star target, and the innovative drug market in China has naturally become the priority layout direction of many enterprises. Even some enterprises have prepared generic drugs in order to avoid the overcrowded innovative drug track. On December 18, 2020, Qilu Pharmaceutical’s piperacillin generic drug (the first imitation) was approved by the Food and Drug Administration, waiting for the piperacillin patent to expire in 2023 and enter the market at any time. After Qilu, more than 20 companies also took a fancy to piperacillin generic drugs. Only five companies, including Kelun Pharmaceutical, Osekan, Haosen, Xiansheng and Shanxiang Pharmaceutical, are in the stage of listing application. Even the same innovative drug track also has more than ten products in the clinical stage, such as Zhengda Tianqing, Beierda Pharmaceutical and Jinzhou Aohong. Although the market prospect is attractive, its involution degree is even worse than that of PD-1/L1, and Darceli of Hengrui, even if the national health insurance talk is successful, has little advantage in price and time to market regardless of efficacy. Not surprisingly, the drug of Hengrui will appear at an "amazing" price reduction in this national talk. 　　

Rivirutamide　 　 　　

As for the last Rivirutamide, as a new drug that entered the division time on June 29th, it is mainly used for metastatic hormone-sensitive prostate cancer with high tumor load, and it is also the first new androgen receptor (AR) inhibitor independently developed by China. According to the publicity content of Hengrui, compared with the standard treatment, the overall survival OS of Rivirutamide has been significantly prolonged, and the risk of death and disease progression has been significantly reduced by 42% and 54% respectively. However, it is still unknown whether it can provide a brand-new excellent treatment scheme at present, and it will take some time to be verified by the market.

02

The "involution" of PD-1 situation is still the theme.

Of course, in addition to the above three new drugs, Hengrui’s national talk about PD-1 this year is also one of the most concerned contents and one of the biggest attractions.

First of all, Karelizumab is the only PD-1 monoclonal antibody in the current catalogue that is about to expire. On the premise of the failure of negotiations on nasopharyngeal carcinoma last year, plus the new indications for first-line esophageal cancer and first-line squamous NSCLC this year, the number of items to be discussed increased to four this year.

At the same time, because esophageal cancer and NSCLC are the major diseases with the highest morbidity and mortality in China, it is expected that this year it is very likely to form a "packaged" admission situation-four indications will enter medical insurance at the same time.

Of course, the opposite must be a huge price reduction (refer to the previous PD-1 price reduction and renewal, perhaps even more).

More crucially, since the second half of last year, domestic PD-(L)1 monoclonal antibodies have been approved one after another, and three domestic PD-1 and two domestic PD-L1 may also join the battle in this national medical insurance talk.

This year’s PD-1 national health insurance talk must be another bloody storm.

03

summary

On the whole, perhaps innovation is indeed the way out for Hengrui, but this road is not as smooth as expected.

At least for the time being, Hengrui, who has temporarily passed the centralized mining safely, may face the real problem of "future" in the next step. The innovative drug market, which looks like scenery, is also full of crises, and involution will become the most important rhythm in the next few years or even decades.

In recent years, under the influence of a number of policy adjustments, leading enterprises such as Hengrui are far less able to accurately control and grasp the main trend of the market, and the advantages they can show when competing with biotech enterprises are not as good as before.

The only way to finally change the present situation is time.

　　On New Year’s Eve, the whole family sits around the table and gossips. Naturally, there is a big dinner. However, as the Spring Festival approaches, while people are ready to enjoy the delicious food, all kinds of rumors about food are beginning to stir up: "I heard that chicken chops contain meat glue and can’t be eaten!" "Don’t you know? Fish belly is poisonous! " "Alum is used for fried melon seeds, so buy it carefully." … … Under many rumors, everyone was inevitably affected and began to panic. "You can’t eat this or that. How can you spend this year?"

　　Chicken chops with minced meat, poisonous fish maw and alum melon seeds … … How many of these rumors are true? How much is alarmist?

　　Does the chicken steak contain meat glue? Edible within the standard range

　　In recent years, delicious chicken chops have gradually become the new favorite on the New Year’s table. Compared with chicken, chicken chops are more beautiful in appearance, convenient to cook and rich in taste, and also avoid the trouble of removing bones on the dining table. But from the beginning of popularity, chicken chops seem to have their own "topics". Many people think that chicken chops are not natural products, but are synthesized with meat glue in the later stage and cannot be eaten at all.

　　What is meat glue? Is the meat glue in the chicken chops brought by the chicken or added during the production process? Are chicken chops really inedible?

　　"Meat glue is actually an enzyme, the scientific name is glutamine transaminase, which can make protein molecules form sponge-like ‘ Network crosslinking ’ Structure. The meat stuck together by it, in appearance ‘ Perfect ’ It will not be dispersed during cooking and processing, and the taste will be better. " Zhang Tian, nutritionist in charge of clinical nutrition department of Aviation General Hospital of China Medical University, told the Science and Technology Daily reporter.

　　According to GB2760-2011 "Standard for the Use of Food Additives", glutamine transaminase, also known as meat glue, is a stabilizer and coagulant, and the maximum dosage is 0.25 g/kg.

　　Zhang Tian said that the chicken chops we usually eat are very large. Of course, this is not taken directly from the chicken, but we need to integrate different sizes of chicken with meat glue.

　　"So chicken chops do contain meat glue, and how much meat glue is contained in chicken chops often depends on the merchants at present." Zhang Tian added, "The market supervision standard for producing big chicken chops with meat glue as an additive is not clear at present, but we can temporarily refer to the standard of bean products. In short, eating too much chicken chops containing meat glue is definitely not good for your health. "

　　Not only chicken chops, but also other meats on the table, everyone needs to be temperate.

　　Is the "black film" of fish belly poisonous? It’s no problem to eat at ease

　　People give the beautiful meaning of "more than one year" to the fish dishes on the table. On the New Year’s Eve table, fish is an essential dish. Recently, it has been said that "a layer of black film on the belly of fish gathers all kinds of toxic substances in the belly of fish, which will be poisoned if eaten".

　　This rumor makes many people wonder, "have I eaten poisonous fish for so many years?" Do you eat fish or not? "

　　In this regard, Zhang Tian said that this statement is unreliable. "The black membrane on the fish belly is called peritoneum, which exists between the abdominal wall and internal organs of the fish and is a normal physiological structure." Specifically, peritoneum refers to a layer of mucosa existing in the abdominal cavity of some vertebrates. It wraps most of the organs in the abdominal cavity, and can secrete mucus to wet the surface of organs, reduce the friction between organs and reduce the damage to internal organs caused by impact.

　　Not only fish, but also other animals have such a film on their bellies. So, why is this film black and looks like poison? Zhang Tian explained that the color of the film is related to the pigment of the fish itself. Not all the films on the belly of the fish are black, and some are light or colorless.

　　Obviously, the color of fish belly membrane can not be used as a criterion to judge whether fish is poisonous or not. The view that eating the black film on the belly of fish will lead to poisoning is not credible. It seems that this year’s Spring Festival, "fish every year" can continue to be served on the table.

　　Drinking in the cold in winter? Drinking too much makes you feel cold.

　　During the Spring Festival, when friends and relatives get together, it is inevitable to have a few drinks. Recently, there seems to be a lot more rumors about alcohol.

　　Drinking is harmful and not beneficial? People who like drinking have different views. They insist that drinking can keep out the cold, and fever after drinking is the best proof.

　　In this regard, Zhang Tian believes that a small amount of drinking does have a certain cold protection effect. "After drinking, the liver metabolizes alcohol substances, and it takes a long time to decompose alcohol, and more calories are produced. At the same time, alcohol stimulates blood vessels and dilates them. Therefore, after drinking, the blood circulation speed in the body is accelerated, the breathing rate is increased, and the heat such as muscles and internal organs is more easily transmitted from the blood to the skin on the body surface, and people will naturally feel obvious fever. "

　　But everything goes too far. After drinking too much, it is easy to cause the loss of heat in the body, which makes people feel cold.

　　"Excessive drinking can cause damage to the liver, brain, nervous system and digestive system." Zhang Tian advised everyone to limit drinking during the Spring Festival, try not to drink high-alcohol and moderate-alcohol wine. Don’t refuse to come because you are happy or "face". Drunkenness and alcoholism are easy to hurt yourself, and those with bad drinking style may even hurt people.

　　Eating durian after drinking causes blood vessel blockage? There is no such thing

　　Near the Spring Festival, there are many rumors about alcohol, and not drinking while eating durian is one of them. Eating durian and drinking alcohol at the same time is more harmful to diabetic patients, which will lead to blood vessel blockage, and serious blood vessel burst and stroke may occur.

　　Regarding the statement that "you can’t eat durian after drinking", Zhang Tian said that there is no basis. Whether eating or drinking a certain food after drinking alcohol will cause harm to health must be based on crowd experiments or epidemiology. At present, no relevant research conclusions have been seen. At present, the medical community is more recognized that only after drinking alcohol can you not take antibiotics, antihypertensive drugs and so on.

　　Zhang Tian also explained whether diabetics can drink and eat durian. "Diabetes patients who drink and eat durian at the same time will not cause blood vessel blockage. Even if this happens, it may be that such people themselves have bad eating and living habits, which may be accompanied by dyslipidemia."

　　Even so, Zhang Tian does not recommend eating durian while drinking. "This will lead to excessive calorie intake and single nutrients, which will easily cause blood sugar fluctuations."

　　Focus

　　Drinking tea after drinking hurts the kidneys? Strong tea has certain influence.

　　In addition to eating durian after drinking, drinking tea after drinking seems to have become the "attack range" of online rumors. All online platforms "Health School" agree that drinking tea after drinking will cause kidney damage. Is there any scientific basis for this statement?

　　Zhang Tian believes that this should be analyzed according to the specific situation.

　　"Drinking strong tea after drinking will have a certain impact on the kidneys, and light tea has little effect." Zhang Tian said that tea contains theophylline, which has diuretic function, so that the metabolites of alcohol in the process of liver detoxification, such as acetaldehyde, can directly reach the kidney before being converted into water and carbon dioxide. As a harmful substance that can stimulate the kidney, acetaldehyde can cause kidney damage. (Intern Ge Junxia, reporter Chen Yu)