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23 Maserati presidents are newly equipped with all kinds of diamond biotite paint.

  Promotion date: February 21st, 2023 to February 15th, 2024.

  2023 3.0T 430Hp Modena Modena Q4

  President of the new listed parallel import! President Q4 Modena 430 horsepower, shocking! China’s only parallel import Maserati President, 430 HP four-wheel drive 3C certificate, high-performance four-wheel drive ultra-luxury car, Ackerman angle steering technology, high-speed cornering vehicles do not shake their tails!

  Car hotline: 13617228389 (WeChat with the same number) Manager Zheng.

  2023 king kong biotite paint-Nero Ribelle/black full leather interior configuration: 1. 21-inch Atlante forged dark gray alloy rim 2. Red calipers 3. Black full leather interior with red stitching 4. High-gloss three-dimensional woven carbon fiber interior: carbon fiber central control panel and interior carbon fiber threshold trim carbon fiber shift paddles 4. Sitting on carbon fiber 5. Advanced driver assistance kit: ?ACC adaptive cruise. Front collision warning with automatic start-stop function, lane keeping assistance and active blind spot assistance function, 360 panoramic parking image system with advanced braking assistance system and automatic emergency braking blind spot warning and reversing lateral collision warning function, intelligent speed assistance system (speed limiter and traffic sign recognition), automatic emergency braking (pedestrian recognition function), advanced active driving assistance system 6, front seat ventilation function, Bowles & Wilkins Bowers&Wilkins Baohua Wei built high-end surround sound system, electric throttle, brake pedal adjustment and punching, high-end leather full leather interior (extended coverage), leather sports steering wheel-with heating function, 7. Luxury executive 4-seat, rear comfortable seat, rear comfortable backrest angle adjustment, rear comfortable seat front and rear adjustable sunshade. The rear seats are ventilated and heated,Independent four-zone comfortable air conditioner 8, remote control start function 9, wireless charger 10, Nerissimo Obsidian black carbon fiber kit: black window door frame trim highlights black front grille carbon fiber rearview mirror cover carbon fiber door handle blackened LED headlight black exhaust pipe black exterior trim (trunk trim, grille upper blade, side vent, logo) blackened rear taillight carbon fiber B-pillar exterior trim carbon fiber front lip 11, electric self-suction door

  In terms of appearance, the new car has not changed much compared with the current models. The front face adopts a straight waterfall air intake grille, and the interior is decorated with vertical chrome plating. With the trident logo in the center and sharp headlights on both sides, the whole car is highly recognizable, and the side lines of the car body are smooth, providing a brand-new 19-inch wheel hub, and adding a special logo at the front fender. The president MODENA Q4 is the Modena logo. The tail is equipped with split taillights and a spoiler with duck tail shape, and the exhaust layout with four sides is below.

  For the interior, the new car is equipped with a three-position multi-function steering wheel, shift paddles, a 7-inch LCD+mechanical pointer instrument and a 10.1-inch central control screen, and is equipped with a new generation of MIA intelligent auxiliary multimedia system.

  In terms of power, both models are equipped with a 3.0T V6 twin-turbo engine, in which the maximum power of the GT engine is 257 kW and the peak torque is 500 Nm, and the maximum power of the MODENA Q4 engine is 316 kW and the peak torque is 580 Nm. The transmission systems are all matched with an 8-speed automatic manual transmission.

  Company name: Tianjin Zhongcheng Weiye International Trading Co., Ltd.

  Car hotline: 13617228389 (WeChat with the same number) Manager Zheng.

  Company address: No.386 Jingmen Avenue, Tianjin Port Bonded Zone, Binhai New Area, Tianjin

  Disclaimer: The above car purchase preferential information is provided by the comprehensive dealers of this website, and the price fluctuates greatly due to market factors, which is only for car purchase reference; The distributor is responsible for its authenticity, accuracy and legality, and this website does not provide any guarantee or assume any legal responsibility.

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A comprehensive view of the Middle East Why does the BRICS countries occupy four seats in the Middle East for the first time in 12 years?

  On the morning of August 24th, local time, the 15th meeting of BRICS leaders held a special press conference to announce the expansion of BRICS members. UAE President Mohamed bin Zayed Al Nahyan immediately expressed his gratitude to the BRICS leaders for approving the inclusion of the UAE in this important mechanism. Fahmi, a spokesman for the Egyptian Presidential Palace, also issued a statement saying that Egyptian President Seyce is very much looking forward to strengthening cooperation with BRICS countries in the future, hoping to raise the voice of developing countries in the face of various development problems and challenges and support the rights and interests of relevant countries. Among the six countries newly invited to join the BRICS family, Egypt, Iran, Saudi Arabia and the United Arab Emirates are all located in the Middle East. People can’t help but ask, why has the Middle East become the biggest winner of this BRICS expansion?

  △ The BRICS leaders’ meeting held in South Africa attracted much attention from all walks of life before the opening because it involved expansion.

  Judging from the development process, the universal appeal of BRICS to developing countries around the world, including the Middle East, is the primary reason. Since South Africa joined in 2011, the BRICS countries have been formally formed. Over the past 12 years, they have maintained a stable structure, always devoted themselves to the construction of cooperation mechanisms, actively participated in international cooperation and global governance, and constantly expanded the "circle of friends" of openness, tolerance and win-win cooperation, and their influence in global governance has continued to increase. After more than ten years’ development, the cooperation foundation of BRICS countries has become increasingly solid, the fields have gradually expanded and the cooperation results have become increasingly fruitful. As of August this year, more than 40 countries have hoped to join the BRICS cooperation mechanism, and more than 20 countries have formally applied for membership, including 9 Middle Eastern countries.

  The close economic ties between the BRICS countries and the Middle East have also made the desire of countries in the region to join the BRICS stronger. Edward bell, head of market economy of UAE National Bank, said that China and India are important trading partners of Saudi Arabia and UAE, and the measures taken by BRICS countries to continuously improve the international trading system will have a long-term positive impact on relevant economies. Monica Malik, chief economist of Abu Dhabi Commercial Bank, believes that joining the BRICS countries by major energy exporters such as the United Arab Emirates, Saudi Arabia and Iran will help expand their economic influence. As a global trade and service center, it is of great significance for the UAE to become a part of the BRICS mechanism, especially to participate in the discussion and development of the BRICS in the future, which is crucial for the UAE to consolidate its position as a net capital exporter.

  △ Before being invited to join the BRICS cooperation mechanism, Egypt and other countries have joined the BRICS New Development Bank.

  The development experience of BRICS countries, especially China, is an important reason why Middle Eastern countries attach importance to this cooperation mechanism. Nasser Saidi, former chief economist of Dubai International Financial Center, commented that the Middle East countries are facing common challenges in many economic fields, among which it is particularly critical to deal with climate change, energy transformation, infrastructure development and poverty alleviation. In particular, many oil-producing countries have been committed to realizing economic diversification in recent years to get rid of their dependence on oil revenue. Joining the BRICS mechanism is of great benefit to these countries in formulating solutions that are in line with their national conditions.

  △ Nasser Sadie, former chief economist of Dubai International Financial Center

  It is worth mentioning that China has played an important role in promoting new members, including four countries in the Middle East, to join the BRICS. In 2022, after China took over as the BRICS president country, it started the expansion process, pushed the leaders of relevant countries to reach an important consensus on BRICS expansion, and supported the discussion on the expansion standards and procedures. Since then, China has been steadily promoting the expansion of the organization together with BRICS members, and expressed its support for the four Middle East countries to join the BRICS cooperation mechanism on different occasions. Analysts said that the full trust of the four countries in China is also one of the driving forces for them to join the BRICS quickly, while China keeps pushing relevant countries to participate in the BRICS, hoping that the members of this cooperation mechanism will be more diversified and cover more dynamic emerging economies.

  Looking at the development of BRICS, from an economic investment concept to an important economic cooperation platform, the process of emerging market countries and developing countries gradually improving their voice in global governance also reflects the common aspiration of developing countries to promote unity and self-improvement, defend multilateralism, safeguard international fairness and justice, and improve global governance under the situation that the world has undergone unprecedented changes in the past century.

  △ South Africa welcomes the BRICS Summit

  As South Africa’s Special Envoy for Asia and the BRICS, Sucral, said, the BRICS countries are a very inclusive organization and have always been willing to engage in dialogue with the wider international community. In November 2022, Algeria formally applied to join the BRICS countries, and Kuwait, Bahrain, Morocco, Palestine and other countries in the Middle East are also looking forward to receiving the invitation from the BRICS, which gives us reason to believe that the joining of new members, including four countries in the Middle East, is only a new starting point for BRICS cooperation, and more new members will inject new vitality into the BRICS cooperation mechanism.

  Producer Mu Muli

  Producer Li Chao

  Reporter Jaz Li

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The exposure life of the rendering of BMW i4 production version can reach 600km.

  [Aika Auto Overseas New Car Original]

  A few days ago, overseas media exposed the rendering of the production version of BMW i4. It can be seen that the new car is based on the i4 concept car released at the Beijing Auto Show, but many details have been changed in mass production. It is reported that the BMW i4 is built on the CLAR platform and will be equipped with the fifth-generation eDrive technology, and the comprehensive cruising range of WLTP can reach 600km.

The exposure life of the rendering of BMW i4 production version can reach 600km.

Bmw i4 concept car

  Judging from the rendering of this exposure, the production version of BMW i4 is based on the previously released concept car, but the appearance details have been adjusted. For example, we found that the headlights of the production version of BMW i4 have become more similar to the 4 Series, which is more in line with the requirements of production cars. In addition, the new car has added more blue elements to the front grille to highlight its identity as a new energy vehicle.

The exposure life of the rendering of BMW i4 production version can reach 600km.

Bmw i4 concept car

  As for the tail, the overall shape of the production version of BMW i4 continues the design of the concept car, but the lines are more muscular. In addition, the rear surrounding shape of the new car has been adjusted to some extent compared with the concept car, and the blue decorative board has a larger area.

Bmw i4 concept car

  As for the interior, referring to the previously released concept car, the BMW i4 adopts the driver-centered design concept, and the new curved display screen is combined with the steering wheel to show the innovative design in the future. The information display screen and the control display screen are merged into a whole device inclined to the driver. Screen grouping can optimize the way of displaying information content, and provide more intuitive touch screen operation, and almost all operating functions are integrated into the display screen, thus reducing the number of touch controls to a minimum.

Bmw i4 concept car

  In addition, the central control panel of the new car replaces the traditional shift lever with a paddle shift button, and the components such as the iDrive control button and the seat memory button are all made of crystal components. The seat material is composed of superfine fiber with line pattern and natural leather tanned with olive leaves, which embodies the design concept of environmental protection and sustainability. In addition, the BMW i4 concept car comes with three different driving experience modes, and there will be exciting visual differences among the three experience modes ("personal", "sports" and "efficient"), from the display screen and picture to the presentation of the interior.

Bmw i4 concept car

  In addition, the BMW i4 not only has a fashionable shape, but also has a unique voice. It was jointly developed by Hans Zimmer, a world-famous composer, and Renzo Vitale, a BMW audio designer, under the brand of BMW IconicSounds Electric, aiming at making BMW electric cars more emotional and reminding other road users with personalized voices. For example, when switching from the "core" mode to the "sports" mode, the sound of the BMW i4 concept car will gradually increase and become louder, including the sound of opening the door and starting the vehicle.

Bmw i4 concept car

  In the power system, the new car is equipped with the fifth-generation BMW eDrive electric drive technology, with a maximum output of 390kW(530Ps). It is equipped with a battery pack with a capacity of 80kWh, with a cruising range of 600 km (under WLTP), an acceleration time of 0-100km/h of only 4s and a top speed of over 200km. In addition, the maximum charging power of the new car is 150kW, and it only takes 35min to charge the power to 80%.

Wonderful content review:

Real shot BMW i4 concept car performance comparable to M4 electric car.

Beijing Auto Show: BMW i4 concept car officially launched in China.

Technical analysis of BMW i4 concept car in its bones.

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The epidemic situation has made us cultivate a lot of habits, and there are many details worthy of attention.

  Wear a mask, wash your hands frequently, and use chopsticks and spoons … … The epidemic situation in COVID-19 has made us pay more attention to the health habits in our lives. Many details of life that have been repeatedly mentioned before but are easily overlooked can benefit our physical and mental health a lot if we stick to them seriously.

  In fact, there are more details in daily life that deserve our attention. Whether it’s breathing, sitting posture, relaxing, eating and walking, exploring some scientific doorways and making some small changes may make our life more healthy and enjoyable.

  Learn to breathe correctly

  Improve memory and sleep

  Breathing may be the most natural thing in the world, but more than half of people in the world breathe in the wrong way. In fact, whether the breathing method is correct is much more important than we thought — — Correct breathing can improve our memory and improve our sleep quality.

  The correct way is to breathe through the nose. The nose that stands out obviously on our face is carefully designed by nature: the nose hair and snot in the nose can catch dust and other foreign objects in the air; The nasal cavity behind the nose is a spongy space almost as big as the oral cavity; The nasal mucosa in the nasal cavity can adjust the temperature and increase the humidity, not only adjust the air that is too cold or too hot inhaled from the outside to the temperature equivalent to the body temperature, but also can trap pathogens with mucus; Sinus is an air-filled space connected with nasal cavity, where air circulates, increasing more nitric oxide, killing bacteria and viruses, dilating respiratory blood vessels and letting more oxygen enter the blood.

  People may not understand that breathing through the nose will increase the air resistance by 50% compared with breathing through the mouth, so that the cardiopulmonary function can be exercised more, and the inhaled oxygen can be 20% more than breathing through the mouth.

  The benefits seem to be more than that. Breathing through the nose can also promote brain function. It is found that the young rats who breathe through their mouths complete the maze task more slowly than the young rats who breathe through their noses, and there are fewer neurons in the hippocampus (an important part of the brain for learning and memory) in adulthood. The human memory test found that people who breathe through the nose have stronger memory ability and better test scores.

  Scientists explain that the nasal cavity can connect with the olfactory bulb of the brain through sensory neurons and establish direct contact with the emotional and memory processing center of the brain. In addition to transmitting odor information, these neurons can also sense the air entering and leaving the nasal cavity, and lock the brain waves synchronized with these airflow, and then transmit these synchronized brain waves from the odor processing brain area to the brain area responsible for memory, emotion and cognition.

  However, many people who breathe through their mouths miss out on these benefits. It is estimated that 50% of children and 61% of adults often breathe through their mouths. Frequent breathing through the mouth will bring about bad breath, poor sleep, learning difficulties, bad teeth, and even lead to jaw deformity.

  People who occasionally breathe through their mouths should give themselves a wake-up call to remind themselves to pay attention to their breathing methods at all times and how they breathe during the day and night. If you find yourself breathing through your mouth often, you can take some corrective measures, such as buying a roll of tape paper and sticking your mouth when you sleep at night. A small study found that this method can reduce snoring and drowsiness in patients with mild obstructive sleep apnea.

  Mastering the breathing frequency can also bring many wonderful uses. For example, if you want to be calm, reduce the number of breaths to six times per minute, which can trigger the body reaction of vasodilation and slow heart rate. At the same time, concentrated thinking and slow and long exhalation can also stimulate the vagus nerve, which is specialized in rest and digestive reaction, and the corresponding fight and flight reaction. If the number of breaths is reduced to three times per minute, then θ Brain waves will increase, and people will feel sleepy at the same time.

  But whether the breathing frequency is fast or slow, breathing through the nose is the best choice. When breathing through the nose, you might as well hum a minor tune. Humming through the nose can stir the airflow in the sinuses and promote the production of more nitric oxide, sometimes up to 15 times as much as usual, which is of great benefit to the immune system and cardiovascular and cerebrovascular systems.

  Change the traditional sitting posture

  Avoid sedentary risks.

  When it comes to correct sitting posture, we may all know not to lean back lazily or cross your legs, but many people may not be able to strictly abide by it. However, even if the standard sitting posture is adopted, sedentary is very harmful to health. Studies have shown that sedentary behavior is equivalent to smoking, which will increase the risk of heart disease, diabetes and even cancer. There is no doubt that we should all try to sit less and move more, and perhaps adopt a more suitable sitting posture, which is more conducive to our health.

  A classic survey report describes 100 different sitting postures adopted by different cultures all over the world, among which the most common ones are sitting cross-legged, kneeling and squatting. These are also the sitting postures that children like, but more people are often used to understanding "sitting" as "sitting in a chair". This brings a big problem — — Sedentary.

  We might as well see how the Hazards sit. Haza people are a modern hunter-gatherer tribe in Tanzania. They sit for about 9 hours every day on average, but instead of sitting in a chair, they take various postures, such as squatting or sitting on the ground in different postures. Activity monitoring shows that these sitting postures require significant muscle activity, thus avoiding the disadvantages of sedentary. The support of the chair, including the high backrest and armrest, will eliminate this muscle activity, but this may be the reason why people like to sit in the chair.

  Yue Se Bettaney-Saltikoff of the University of Teesside, UK, thinks that ordinary chairs will put more pressure on the back if the lower part of the back lies flat on the back of the chair.

  So, what is the best sitting posture? Bettaney-Saltikoff found that kneeling or using a stool with a saddle can help keep the spine in the best position, and squatting is also possible.

  Leon strack, a physiotherapist at Curtin University in Australia, said that people can adopt some active sitting positions to avoid being still for a long time.

  Strack also put forward some suggestions to fundamentally change the sedentary situation of copywriters. For example, design a more scientific working environment so that people can improve their work efficiency while doing a little activity — — Maybe we can design a desk that can do cycling or walking under the desk from time to time. At present, if the nature of your job makes you have to sit for a long time, please don’t forget to stand up and stretch your legs often.

  Try to meditate

  Release pressure with "micro-relaxation"

  In fact, it is not easy to work at home. Every day, in addition to finishing the work, children should be allowed to eat and play. It may be after 9 pm when the children go to bed, wash clothes and tidy up everything. Finally, I can sit down with my lover and turn on the TV — — At this moment, I have been looking forward to it for hours.

  Relaxation makes us happy and is a natural medicine to eliminate fatigue. More and more evidence shows that persistent high pressure will lead to chronic inflammation, which is very unfavorable to our physical and mental health. However, is watching TV the best way to relax?

  On this issue, Claudia Hammond and Gemma Lewis of University College London, UK, surveyed 18,000 people from 134 countries and found that watching TV is one of the top ten relaxation activities that people usually do. At the same time, 68% people want to have more rest, because rest is also an unconscious relaxation.

  Can running be regarded as a way to relax? Patricia Gebhardt, a doctor at New York Medical College, believes that both sympathetic and parasympathetic nervous systems are related to unconscious behavior. The sympathetic nervous system will enhance the fight-or-flight response and produce harmful particles called free radicals. When relaxed, the parasympathetic nervous system will start, giving the body a chance to recover from fatigue.

  "People don’t feel dangerous when jogging," Gebhardt said, which means that the sympathetic nervous system will not respond. "Especially when people often jog in the natural environment, it will make people feel more peaceful." In addition, exercise also produces a pleasant chemical endorphin.

  However, sometimes people need to decompress, but they don’t have time to jog or watch TV. At this time, they need a kind of "micro-relaxation". Meditation may be a micro-relaxation habit worth cultivating. There is evidence that meditation can reduce the activity of amygdala, which is the part of the brain involved in the fight or flight response. When entering meditation, the brain will stop most of its activities and concentrate on meditation and the surrounding environment.

  A research test at La Salle University in Philadelphia, USA, shows that meditation can really make people enter an "absent-minded" state of relaxation. There is a skill to cultivate this state consciously and relax yourself at any time of the day. For example, try to wait for the bus absently, focus on the details of the surrounding environment you see, hear, smell and perceive, and let yourself enter a calm and wave-free state of relaxation.

  Eat regularly and eat slowly.

  Concentrate on eating and don’t eat too much.

  Eating can be said to be the top priority in life. From the time and speed of eating to the choice of dining companions, the way of eating will have a great impact on our waistline and happiness.

  First of all, talk about meal time. Many of us are accustomed to regard dinner as the most important meal of the day, but in fact, our bodies are more sensitive to insulin in the morning, and the peak blood sugar drops faster after breakfast than after dinner. Leonie Ruddick Collins of the University of Aberdeen in the United Kingdom pointed out that in the morning, the stomach is emptied, the intestinal peristalsis is faster, and the acid content of enzymes, peptides and bile is higher. Therefore, a reasonable breakfast can reduce the risk of diabetes, which is also good for intestinal health and digestive system.

  Regular meals are also beneficial, which helps to regulate the genes that control the biological clock. Changing the meal time often will interrupt this coordination. In addition, people with weight loss goals can limit the interval between meals to a short time, such as delaying breakfast for 90 minutes and advancing dinner for 90 minutes. By doing this, you can lose twice as much fat in ten weeks as those who keep a normal diet.

  The speed of eating is also important. Chewing 100 times per bite may be too much, but people who eat slowly do eat less, which may be because the hormones released after eating take about 20 minutes to work, and eating slowly is more likely to produce satiety. At the same time, eating foods with high fiber content will also require more chewing, which will slow people down.

  Fast eaters tend to have higher levels of triglycerides in their blood. Triglyceride is a key indicator of metabolic syndrome. Although the reason is not clear, the researchers suggest that we should focus on food and sit down safely when eating to avoid interference from TV, computer and mobile phone.

  One more question, is it better to eat alone or together? Even if there is no need for epidemic prevention and control, busy life and families living alone make eating alone more common than in the past. Research suggests that this may be a good thing. Helen Ruddock of the University of Liverpool, UK, found that although eating with friends often leads to happiness and higher life satisfaction than eating alone, people eat more when they eat with friends. Perhaps, it is a way to kill two birds with one stone by eating leisurely with friends who have good eating habits and like to eat slowly.

  Optimistic gait walking

  Keep walking every day.

  Walking on two feet is actually a very dangerous way, so few species except humans will adopt this way of walking. Although incredible, we still use these two small platforms to keep balance and move, but we rarely think about how to walk is really beneficial to health.

  Although the way we walk is basically the same, everyone’s gait is different, and the difference is even enough to be used as a biometric password. However, some weird gait may be a problem.

  For example, a slight change in leg swing may cause damage to knee cartilage caused by the force of heel hitting the floor. In the past 50 years, the incidence of knee osteoarthritis has doubled, and it is not enough to explain it only by the increase of human life expectancy or obesity rate. Walking barefoot or wearing flat and light shoes can reduce the pressure on the knees, but high heels, on the contrary, will bring more pressure on the knees, so changing a pair of shoes that fit the feet may be good for the knees.

  The way you walk will also have many effects. Experiments show that people who walk with "optimistic" gait can remember more positive words in the list, while people who walk with "sad" gait will remember more negative words. For the "low-headed people" who like to watch their mobile phones while walking, this will not only lead to slower walking, but also may lead to neck strain and injury.

  Daniel Lieberman, an evolutionary anthropologist at Harvard University in the United States, made a health survey of modern hunter-gatherers and postal workers. It shows that our goal should include walking for two hours every day, but most people can’t achieve this goal. Therefore, don’t worry about whether your gait is different from others, just keep walking every day. (Fang Lingsheng/Compiled)

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The domestic BMW X5 is 130mm longer. If it sells for 558,000 yuan, the only thing that can stop it is the production capacity?

"When will the extended version of the domestic BMW X5 come out?" Many classmates and friends around me consult me from time to time.

No, it’s coming! On March 1st, BMW (China) released the official map of this car and some key information: the car was officially named as.BMW Brilliance X5 L, available in 30Li(2.0T) and 40Li(3.0T) versions, is a special model for the China market. It is produced in Tiexi Factory in Shenyang and will be listed soon.

After the X5 was made in China by BMW Brilliance, the car body was lengthened by 130mm, and the wheelbase reached 3105mm, which was the longest in its class. BMW’s American factory will reduce the X5 production schedule, but the import of standard axle models will not stop in a short time.

(The words "BMW Brilliance" at the end clearly indicate the identity of its domestic car. )

X5 has been made in China for a long time. On December 8, 2021, the Ministry of Industry and Information Technology issued the 351st batch of Announcement on Road Motor Vehicle Manufacturers and Products, and the domestic version of BMW X5 was impressive.

Domestic production of luxury medium and large SUVs is not special. Lincoln aviator and British finidi QX60 have been produced in China, and Volvo XC90 and Audi Q6L have also announced that they will be made in China. Why is X5 the most concerned? Because it is a BMW, it has its own aura.

How hot is the domestic X5 L? At present, some 4S stores have begun to accept reservations. Only one hour after the pre-sale, the whole order has exceeded 8,000 units. Don’t forget, it is an expensive medium-sized and large luxury SUV.

The domestic BMW X5L has such a high degree of attention, and consumers are most concerned about the price.

Since it has not been officially listed, BMW has certainly not announced the official price. But now there is a crazy price circulating in the market-starting from 558,000 yuan, and it is claimed that this is information provided by insiders with an accuracy rate of 99%.

This price is so shocking that it is nearly 150,000 yuan cheaper than the original imported X5.7 million yuan, and even cheaper than the imported Touareg.

Even at a price of nearly 700,000 yuan, the imported BMW X5 still cut the sales of more than 50,000 vehicles in 2021, ranking first in the same class. After domestic production, the price has dropped to 500,000, while Mercedes-Benz GLE and Audi Q7 are still imported cars, and the price is more than 700,000 yuan, which is estimated to be enough.

Lincoln Aviator, Cadillac XT6 and British finidi QX60 are cheaper than domestic BMW X5, but their brand appeal is not the same as that of BMW.

Of course, some people are skeptical about the price of 558,000 yuan. Because the price of BMW 5 Series has not changed much when it changed from the original imported standard axis to the long version of 5 Series Li made in Canada; The 3 series has changed from imported to domestic extended version, and the price has not changed much.

BMW has neither admitted nor denied the price of 558,000 yuan, giving people a lot of imagination. So some people think that the price from 55.8 is possible. When X3 was made in China, it was 100,000 yuan cheaper than the imported version.

Because BMW Brilliance’s shareholding ratio, BMW’s shareholding ratio has been approved to 75%, even if the price is lower, the profit distribution is higher.

In terms of market positioning, in 2021, BMW listed the pure electric SUV iX, and the price of the car was 746.9-996.9 thousand yuan, which is exactly the price range of the original imported BMW X5, and may replace the market position of BMW X5 in the future.

Therefore, BMW probably wants X5L to play a combination boxing with iX. Want to further develop the maximum surplus value of BMW X5 in China market.

Another reason is that the BMW X5 overseas model is facing a mid-term change, and the domestic BMW X5L is the old model before the mid-term change. Therefore, it is not excluded that BMW will still keep the imported X5 and continue to sell it. Domestic X5L takes the cost-effective route, while imported X5 takes the performance route.

In addition, BMW is in a strong position in China. Last year, it completed 845,000 vehicles in China, 100,000 ahead of Mercedes-Benz, and this year’s target is 1 million vehicles.

To achieve the sales of 1 million vehicles, the domestic BMW X5 L shoulders the heavy responsibility, and of course, it is necessary to set a competitive price.

BMW summed up nine highlights for the brand-new domestic X5L, and the intelligent laser headlights ranked first, but consumers are more concerned about the longest wheelbase of 3105mm. Generally speaking, it is inevitable that the handling performance will be reduced after the vehicle is lengthened, but consumers can’t stop the temptation of lengthening.

Many people are concerned about lengthening the size.The length, width and height of BMW Brilliance X5L (domestic X5 for short) are 5060mm/2004mm/1771mm respectively.

People familiar with BMW may know that the wheelbase of imported X5 is only 2975mm, and the length of domestic X5L has been increased from 4,930 mm to 5,060 mm. The other parameters have not changed, and the wheelbase has been increased to 3105mm, which is comparable to BMW X7, and most of the extended parts have been given to the rear row, thus solving the problem of cramped rear row.

Previously, BMW X5 was an imported car, but it was controversial because of the rear space. Now the localization has lengthened the wheelbase, which means that the comfort of the rear space is expected to be improved.

Luxury cars have benefited from the extension in China market, from Audi A6L to BMW 5 Series, 3 Series, Audi Q5L and Mercedes-Benz GLC, and have achieved great success.

According to the disclosed news, the domestic BMW X5L will be equipped with two sets of power systems, namely, a 2.0T engine with model B48B20G and a 3.0T engine with displacement of B58B30C. Among them, the 2.0T engine is made in China, while the 3.0T engine is still imported.

In the transmission part, it is expected to continue the 8-speed automatic manual transmission of imported models and support the intelligent all-wheel drive system.

Domestic BMW X5L provides BMW 2.0T inline four-cylinder turbocharged engine and 3.0T six-cylinder turbocharged engine which won numerous international awards. Among them, the latter makes the new BMW X5 xDrive 40Li accelerate only 6.0 seconds per 100 kilometers, and the top speed is as high as 238 km/h. With the help of a new generation of BMW xDrive intelligent all-wheel drive system, intelligent shock-absorbing air suspension and electronic shock absorber, and with the adjustment experience accumulated by BMW and a hundred years, the all-terrain driving ability of the car is beyond doubt.

BMW’s fuel engine enjoys a high reputation, but with the international crude oil price rising continuously, the domestic price of No.92 oil has surpassed that of 8 yuan, so it would be better if there is a PHEV version.

This is not impossible, because the imported version of the 2022 xDrive45e M sports suit is the PHEV version, but the price of 859,900 yuan is 100,000 yuan more expensive than the 754,900 yuan 2022xDrive40i M sports suit.

If the domestic BMW X5 PHEV version can set a price similar to that of the gasoline version X5, like the BMW 535Le, and it can also get a green license and be exempt from purchase tax, it is estimated that it will attract a wave of consumers.

Because the domestic X5L will not only face the competition from the original luxury fuel SUV, but also be impacted by the electric products of the models such as Weilai ES7, Li ONE and L9, the X5L’s dominance is also in jeopardy.

With BMW’s enthusiasm to promote the plug-in, it is expected that the gasoline version X5 will be launched first and the PHEV version will be launched later. PHEV can not only improve performance, but also be a more advanced model with "double points".

The huge demand of domestic X5L makes BMW Brilliance’s production capacity a little stretched. According to the inside information of BMW Brilliance, X5 will be produced from April 2022 to 2026, with a planned annual production capacity of 121,000 vehicles, equivalent to a monthly production schedule of 10,000 vehicles.

At present, the existing production capacity of Tiexi and Dadong factories owned by BMW Brilliance is 760,000 vehicles/year, including 200,000 vehicles/year and 160,000 vehicles/year for Dadong new and old factories respectively, and 400,000 vehicles/year for Tiexi factory.

In 2021, the total output of BMW Brilliance exceeded 700,000 vehicles, and the total sales volume surpassed that of Beijing Benz, taking the crown of domestic luxury car retail volume.

According to the public information, the expansion project of Dadong Factory, which started in March 2020, has an additional capacity of 240,000 vehicles/year, while the new Tiexi Factory, which will be built soon, has an additional capacity of 400,000 vehicles. In other words, BMW Brilliance will once again expand its production capacity through the new projects of Dadong and Tiexi, reaching 1.4 million vehicles/year (three shifts), an increase of 84% on the basis of the existing 760,000 vehicles.

Although BMW Brilliance’s production capacity is ambitious, considering the current shortage of chips and the instability of the global supply chain, how to produce as many X5 L as possible will be the main task to test BMW Brilliance.

Wen | DA Bin

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The death of more than 200 seagulls in Australia caused panic among residents (Figure)

Special topic: picture channel


Profile picture: Birds that died in December 2007.



Seagulls that died in this incident.


  International Online Special: A large number of dead birds fell from the sky in western Australia recently. This is the second time in seven months that such a strange phenomenon has appeared. The appearance of a large number of dead birds has caused extreme panic among local people about health and safety. The cause of the mysterious death of birds is still under investigation.


  The mysterious death of seagulls is a mystery


  This week, more than 200 seagulls died mysteriously in Woodman and Henderson, the most popular seaside resorts in Perth, an Australian coastal city. Experts dissected and tested the gull’s body, but found nothing suspicious. The local government investigated the nearby factories and found no signs of chemical pollution.


  The staff of the environmental protection department believe that a large number of seagull deaths may be caused by the leakage or pollution of some chemical substance. It is reported that there is a large shipbuilding factory near Woodman. Experts have taken samples of seawater near the factory and are currently conducting inspection.


  5000 birds were poisoned last year.


  In December 2007, 5,000 dead birds fell from the sky in Reims, Espe, 500 kilometers southwest of Perth. After investigation, these birds were poisoned by a toxic chemical. After the appearance of dead birds, the Australian government once declared Reims, Espe as a disaster area.


  The dead birds are mainly yellow-throated warblers, Dutch honeyfinches, etc., and there are also a few crows, pigeons and eagles. According to eyewitnesses, these birds were in great pain before they died, and their bodies kept twitching. Australian wildlife officials called it a "catastrophic event." After the incident, the staff of relevant departments conducted random inspections on local residents and found that there were potentially harmful elements in their blood.


  Death is limited to seagulls.


  Kevin Morrison of the environmental protection department said in an interview with the Australian Broadcasting Corporation that compared with the massive death of birds in December last year, it seems that the seagull who died this time did not experience too much pain, but died quickly and peacefully. Morrison said: "Before they died, these birds began to walk unsteadily. They sat on the ground and died after 10-15 minutes. What puzzles me is, why are all seagulls killed this time? "


  A few days ago, Woodman Beach has been blocked. The local government hopes to find out the cause of seagull death as soon as possible. (Ru Zhi)

Editor: Feng Ye

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The central government’s policy to curb corruption is powerful. Before the holiday, high-priced moon cakes were cold.

Editor’s Note: The Mid-Autumn Festival National Day is approaching. Under the prohibition of unhealthy trends such as public money and gifts in CPC Central Commission for Discipline Inspection, the sales of moon cakes nationwide are "cooling down" compared with previous years, and gifts such as "sky-high moon cakes" have reduced their stature, with less over-packaging, and fair price gifts have gradually become the mainstream. People’s Daily launched a special report on "Focus on Two Festivals". The reporter interviewed large shopping malls and supermarkets in Beijing to observe the new changes in festivals under the central government’s policy of curbing corruption.

People’s Daily Online, Beijing, September 16 (Reporter Jia Yue) The annual Mid-Autumn Festival is coming. A few days ago, the reporter learned from several large supermarkets, pastry shops and online shopping malls in Beijing that this year, due to the reduction of group purchases by government, foreign companies and state-owned enterprises, the sales volume of moon cakes generally declined, and the overall price of moon cake gift boxes tended to be in the middle price range, but the phenomenon of over-packaging exceeding national standards still existed.

The experts interviewed believe that the living space of "sky-high-priced moon cakes" is not large under the background that the central government has continuously issued notices prohibiting public funds from giving gifts, but reducing the potential demand for over-packaging requires the supervision and efforts of the whole society.

The overall sales of moon cakes fell by 30%, and the anti-corruption policy was powerful.

In early September, the reporter came to a large shopping mall in Chaoyang District, Beijing, and saw that a special moon cake sales area had been opened next to the underground supermarket, and well-known moon cake brands such as Dasanyuan, Gongyifu and Quanjude Fangshan gathered together. The reporter walked around and observed that the prices of mooncake gift boxes are mostly below 200 yuan, and most of them are doing activities, some buy one for free, and some directly get a 30% discount.

But even so, there are still not many customers who patronize the mooncake gift box area. Some brand promoters told reporters that the sales of mooncake gift boxes this year are not optimistic. In contrast, the bulk mooncake counters not far away are crowded, and all kinds of mooncakes less than one in 10 yuan are popular.

In the online shopping channel, the price of mooncake gift boxes also tends to be stable. Reporters in the "No.1 shop" search found that most of the top 50 sales prices are within 100 yuan. In Tmall Mall, the best seller is the Daoxiang Village mooncake gift box with a price of 69.9 yuan and 9 Cantonese mooncakes, with a total of 95,000 boxes sold that month.

The reporter noticed that these popular cheap moon cake gift boxes are mostly simple and flexible packages. You can also find mooncake gift boxes with higher prices than those in 400 yuan in online shopping malls. Usually, you choose complicated packaging forms such as bamboo tubes and baskets. From the information provided by the website, there are few sales records in the past month.

"This year’s moon cake sales are mainly aimed at the expansion of the mass consumer market." Feng Enyuan, vice president of China Cuisine Association, recently pointed out that the situation of purchasing moon cakes at public expense is decreasing, so some simple packaged moon cakes, including "naked" moon cakes, are now recognized by consumers.

According to the statistics of the baking professional members of Shanghai Food Association, the sales volume of boxed moon cakes in this city, which is mainly based on the sales of moon cake coupons, has dropped by about 30% as a whole, while individual enterprises have dropped by more than 40%.

According to the analysis of Guangzhou industry insiders, the high-end market of moon cakes has shrunk due to the influence of the big environment, and the consumption of group purchases has decreased. The peak sales of moon cakes have been shortened by more than half a month, and the sales have dropped by 30% to 50%. More manufacturers have revealed that the overall production of moon cakes has decreased by nearly 30% this year.

Wang Yukai, a professor at the National School of Administration, said that the central government’s policies to curb corruption are becoming more and more obvious, and the small moon cakes reflect the big problem of the government’s image. Now party and government cadres at all levels are treading on thin ice to deal with the problem of "giving gifts", which shows the great power of the central anti-corruption policy.

The price of moon cakes plus packaging doubles, and excessive packaging still exists.

Half a month before the Mid-Autumn Festival, the reporter saw in a local brand West Point chain store that all kinds of mooncake gift boxes had been placed in a prominent position above the counter. As soon as the reporter entered the door, the clerk sold one of the gift boxes for 158 yuan to the reporter.

According to the shop assistant, the mooncakes in the gift box are the same as those in bulk, but the difference is that there is an exquisite outer box more than that in bulk. According to the reporter’s calculation, there are 8 mooncakes in the gift box with the price of 10 yuan, which is equivalent to doubling the price of mooncakes with the box.

"We have also cooperated with enterprises to issue mooncake delivery vouchers to employees. Generally, enterprises also choose gift boxes, which may be because they feel that it is impossible to send mooncakes in bulk to employees." The clerk told the reporter.

In the wine sales area of a shopping mall in Dongcheng District, the reporter also saw a limited gift box for the Mid-Autumn Festival. A 488 yuan Remy Martin VSOP brandy at the counter became 598 yuan when it was put in a cardboard box. The shopping guide said that if you don’t buy gift boxes, you can only have general outer packaging, which is not beautiful enough and it is not decent to give people.

In fact, the price limit requirements for food packaging costs have been introduced as early as April 2010. The national standard "Restricting over-packaging of commodities requires food and cosmetics" stipulates that the sum of all packaging costs except initial packaging shall not exceed 20% of the selling price of commodities. Obviously, there are many brands on the market that have violated this clause or are playing the edge ball.

"The lack of laws and regulations makes it impossible to blame for excessive packaging." Dong Jinshi, executive vice president and secretary general of the International Food Packaging Association, pointed out that although national standards have been formulated, there is no clear punitive clause, which undoubtedly provides room for enterprises to over-package in violation of regulations.

Poor enforcement, over-packaging punitive clauses are difficult to work.

A frequently quoted data shows that the value of packaging waste thrown away in China is as high as 400 billion yuan every year, of which 80% of packaging waste is buried together with domestic garbage. These torn packaging materials have caused serious environmental pollution.

"Over-packaging is not unrelated to blind pursuit of GDP." Li Xingguo, a professor at the Department of Social and Cultural Education and Research of the National School of Administration, told this reporter that according to his investigation, many hotels rely on the Mid-Autumn Festival round of mooncake sales to improve their performance. In fact, they are all produced in the same food factory. The cost of mooncakes is similar, but the profit difference is reflected in the packaging, so merchants are generally eager for luxury mooncake gift boxes.

In order to effectively curb the common phenomenon of over-packaging, some regions have begun to formulate local laws and regulations with clear penalties. At the beginning of this year, the "Several Provisions on the Reduction of Commodity Packaging in Shanghai" was implemented, which made it clear that the sales enterprises were the main body of responsibility, and the illegal enterprises that refused to stop selling and the circumstances were serious would be fined from 20,000 yuan to 50,000 yuan.

In August, the "Administrative Measures for Restricting Overpackaging of Commodities in Guangzhou (Draft for Comment)" began to be demonstrated by experts. The opinion draft stipulates that the packaging of moon cakes is prohibited from using textiles, ceramics and precious metals except the initial packaging, and the number of packaging layers must be below three; The packaging of tea is more stringent, and the void ratio of packaging is not more than 25%. Violation of the regulations faces a maximum fine of 100,000 yuan.

Li Xingguo believes that the main reason for the repeated prohibition of over-packaging is poor enforcement. Although it seems that many departments are involved in management, it is not clear who will supervise, implement and punish. Because the provisions are unclear, the relevant powers are not given in place, so it seems that "everyone is in charge and no one is in charge".

"After the publication of punitive clauses, the key is to mobilize the whole society to participate in supervision. Sampling inspection and census are not binding on businesses, and they are motivated to take risks in the face of huge interests." Li Xingguo added, "At the same time, everyone should establish a new concept of environmental protection and simplicity, so as to reduce the potential demand for over-packaging."

Related reports:

Investigation on the rectification of the "two festivals": 40% of adults think that there will be fewer gift-giving parties.

"Corruption on the tip of the tongue" has converged, and two public funds have been severely punished throughout the country.

The sky-high moon cakes are hidden in five-star hotels, and the invoices can be printed into printers.

CPC Central Commission for Discipline Inspection announced the report phone number and website. Welcome to report the unhealthy trend of Mid-Autumn National Day.

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Ten Bad Habits of Environmental Pollution in Chinese

  As one of the main pollution gases emitted by industry, smoke and dust threaten human health and destroy the regional environment. We should optimize the industrial structure, implement cleaner production, and promote enterprises to meet the emission standards.

  The random discharge of sewage will directly destroy the ecological environment, and will eventually affect human health and even survival. We should strengthen sewage treatment and utilization, protect the ecological environment and protect the future of mankind!

  Automobile exhaust is toxic and harmful, and it is emitted at low altitude, which is the main source of air pollution in cities all over the world. We should make a comprehensive policy, combine "sparse" and "blocked", and support the blue sky with automobile civilization.

  A large amount of dust and sulfide volatilized from the combustion of inferior coal is the main source of air pollution. We should promote the clean utilization of coal, keep warmth and blue sky.

  Dust from construction site directly affects air quality while reducing visibility, causing safety accidents and hidden dangers. We should promote green construction, reduce dust pollution and let citizens breathe freely under the blue sky.

  The unorganized discharge of cooking fume intrudes the surrounding residents and pollutes the atmospheric environment. We should upgrade the management methods of catering environment, strengthen the control of lampblack source and create a harmonious environment.

  Burning straw not only produces toxic substances harmful to human health, but also aggravates air pollution and increases the possibility of regional haze weather. We should strengthen scientific guidance, promote the recycling of straw and achieve a double harvest of environmental benefits.

  Open-air barbecue not only affects the municipal appearance, but also directly discharges pollutants into the atmosphere, aggravating air pollution. We should refuse open-air barbecue, taste environmentally friendly food and enjoy a clean life.

  Burning garbage in the open air can produce more than 20 kinds of toxic pollutants, which seriously affect the atmospheric environment and human health. We should strengthen the management of garbage classification, refuse to burn garbage in the open air and build a beautiful home together.

  Pets urinate everywhere, urban sanitation can’t afford to hurt, and urban civilization can’t afford to hurt. We should cultivate our pets in a civilized way, starting from me, and guarding the harmonious life between people and animals.

 

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Stimulate vitality and boost consumption | Hebei Huimin subsidies drive consumption benefit to be obvious

CCTV News:In order to further release domestic demand, the Ministry of Commerce has positioned this year as a "consumption boosting year". Some time ago, the Beijing-Tianjin-Hebei consumption season started. For more than a month, based on their respective characteristics and advantages, Beijing-Tianjin-Hebei launched consumption policies according to local conditions, created consumption activities, and strived to meet the diversified needs of consumers.

March is the off-season of home appliance sales, but in Zhengding County, Hebei Province, no one expected that the 3 million yuan subsidy for home appliances just invested by the government was snapped up by consumers in just one and a half days.

The promotion season has such an effect, thanks to a series of preparations made by the local government and merchants before the event started.

Zhang Chaoyong, Deputy Director of Zhengding County Bureau of Commerce, Hebei Province:Let’s first call the person in charge of Shangchao to hold a forum to give up the maximum discount on the price of the goods. We have to do our work, and in order to gather popularity, we have communicated with shopping malls and manufacturers many times. At first, they refused to let the government pay, so it was very difficult for us. The government’s funds must be strictly controlled and the limited funds should be used to maximize consumption.

After many meetings, it was finally determined that the government and the merchants would pay half the subsidy fee. In March, Zhengding County took the lead in providing 3 million yuan of subsidy funds for household appliances consumption, which means that businesses should also make a profit of 3 million yuan, which is equivalent to the ordinary people getting a discount of 6 million yuan. How can this 6 million yuan benefit the people who really need it?

Song Chunhai, Manager of Zhengding Store of Northland Electric Appliances:The starting line of household appliances subsidy is generally 2000 yuan, which is the average customer unit price of refrigerators, color TVs, washing machines and air conditioners, which is basically more than 2000 yuan. This time, the Bureau of Commerce mentioned Pratt & Whitney, and finally we decided to go to 1000 yuan. Like TV, the elderly sometimes need 42 inches and 32 inches, both of which are more than 1000 yuan. In this way, many customers who just need sex have gained great benefits in this activity.

After lowering the starting line, in Zhengding, no matter local consumers or foreign consumers, they can enjoy 15% government subsidies for benefiting the people if they buy household appliances with a price of 1,000 to 5,000 yuan, and 10% subsidies for those with a price of more than 5,000 yuan. In order to ensure that the benefits the people get are practical and water-free, the local government also spent half a month making another preparatory work before the start of the consumption season.

HebeiZhang Chaoyong, Deputy Director of Zhengding County Bureau of Commerce: I am afraid that they will raise prices. When they say that the government has subsidies and raised prices, the people are equal to not getting benefits, and businesses are making money. Therefore, before this, it is necessary to put on record, and all commodity prices should be put on record in the price management department of the market supervision bureau, and then publicity should be carried out after the record is completed.

Zhengding, Hebei Province invested a total of more than 10 million yuan in promotional funds in March, focusing on the consumption of bulk commodities with obvious driving effects such as automobiles and household appliances. Up to now, directly boosting the consumption of automobile appliances by 200 million yuan has not only boosted the consumption enthusiasm of ordinary people, but also enhanced the business confidence of enterprises.

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Small nucleic acid "big era"-nucleic acid track inventory

Nucleic acids are biological macromolecules, including DNA and RNA. These two kinds of molecules can be used for the prevention, diagnosis and treatment of diseases, which are nucleic acid drugs. Nucleic acid drugs include small interfering RNA(siRNA), small exciting RNA(saRNA), microRNA and messenger RNA(mRNA).

All kinds of common RNA and their functions

5201658273305523 Source: Guotai Junan Securities Research

The appearance of small nucleic acid drugs makes it possible to actively design drug sequences to target silent disease genes. Compared with other drugs targeting proteins, small nucleic acid drugs have the advantages of short preclinical research and development cycle, rich candidate targets, high specificity, high efficiency and long-term effect. 

The candidate targets are abundant and the indications are widely distributed. 

Theoretically, any disease caused by over-expression of specific genes can be treated by small nucleic acid drugs, which provides rich candidate targets for the research and development of small nucleic acid drugs, including many targets that traditional drugs can’t become drugs. 

Simple drug design and short research and development cycle. 

Small nucleic acid drugs are the biggest benefit areas of genomics and functional genomics. The design of small nucleic acid drugs can realize the digital design of disease gene (mRNA) sequences directly, thus getting rid of the large-scale screening cycle of traditional drugs, enabling drug design to be carried out actively, and the success rate of research and development is relatively high.

  Strong targeting specificity

Small nucleic acid drugs can regulate gene expression from the post-transcriptional level, can specifically act on the mRNA transcribed by the pathogenic gene, regulate the expression of the pathogenic gene from the upstream of the disease, and can achieve sequence specificity at the single base level, with the characteristics of "targeted" and "temporary solution". In addition, the continuous innovation of nucleic acid drug delivery system can effectively deliver nucleic acid drugs to target organs, and truly achieve targeted drug delivery.

  Long-acting drug 

On the whole, the effective action time of small nucleic acid drugs is longer than that of traditional small molecules and protein drugs. Taking siRNA drugs as an example, when the target mRNA is degraded, the RNA-induced silencing complex (RISC) can work circularly and participate in the next degradation of the target mRNA. In addition, the continuous innovation of chemical modification technology of nucleic acid drugs, including phosphate skeleton modification, glycosyl modification and base modification, can improve the stability and half-life of nucleic acid drugs, make the drug act longer, and greatly improve the compliance of patients with treatment. The long action cycle makes small nucleic acid drugs have competitive advantages in the fields of chronic diseases such as cardiovascular diseases.

  25201658273305724 

At present, the main nucleic acid drugs listed in the world are antisense nucleic acid (ASO), small interfering RNA(siRNA) and nucleic acid aptamer. In addition to nucleic acid aptamers (which may exceed 30 nucleotides), nucleic acid drugs are usually oligonucleotides composed of 12~30 nucleotides, also known as oligonucleotide drugs. In addition, miRNA, ribozyme and deoxyribozyme also show great development value in the treatment of many diseases. Nucleic acid drugs have become one of the most promising fields in biomedical research and development.       

 Examples of approved nucleic acid drugs

99621658273305772 Image source: Pharmaceutical Online

Compared with the existing small molecule and antibody drugs, small nucleic acid drugs have the advantages of fast target screening, high success rate of research and development, less drug resistance, wider therapeutic field and long-term effect, and have great development potential. Small nucleic acid drugs are expected to cover more indications, so their potential market scale is very broad. It is estimated that the global sales of small nucleic acid drugs will exceed 10 billion US dollars by 2025.

At present, a total of 14 small nucleic acid drugs have been approved for marketing in the world (three drugs were delisted in the early stage), including 9 ASO drugs, 4 siRNA drugs and 1 nucleic acid aptamer. After years of development, heavy products of small nucleic acid drugs have appeared, among which Nusinersen developed by Bojian and Ionis is the first drug used to treat spinal muscular atrophy in the world, and its global sales in 2021 reached US$ 1.951 billion, which is the highest-selling small nucleic acid drug at present. Inclisiran developed by Novartis and Alnylam is a long-acting lipid-lowering drug, which only needs to be injected twice a year, opening a new chapter in the application of small nucleic acid drugs to common chronic diseases. 5751658273305914 Shengnuo medicine The company has the exclusive delivery platform of polypeptide nanoparticles (PNP) in the world, and uses it to develop innovative biopharmaceutical drugs for a variety of disease indications, including oncology, fibrotic diseases and disorders, viral infections and metabolic diseases. At present, STP705, the core product, is the first candidate drug that has achieved positive clinical results in the field of oncology.

  Aibo biology At present, the company’s pipeline covers the fields of infectious disease prevention and tumor immunity, among which the mRNA vaccine developed for COVID-19 has entered the international multi-center phase III clinical research and obtained the drug production license.

  Agner biology The company has independent intellectual property rights of GalPET liver targeting RNAi and lipid nanoparticles (LNP) delivery core platform technology. In March, 2022, COVID-19 mRNA vaccine developed by Agner Bio and Ruibo Bio carried out Phase II clinical trial. 

Ruibo biology Is a nucleic acid technology as the core, the company not only has a variety of chemically modified oligonucleotide drug production capacity and large-scale production base, but also can provide the whole industrial chain production and development services from plasmid manufacturing, raw materials and enzyme production, to mRNA production and LNP preparation and filling of mRNA vaccines. 

Ruibo biology China is the main pioneer of small nucleic acid technology and small nucleic acid pharmacy, and four products are in the clinical research stage. According to the unsatisfied clinical needs, the pipeline of products under research is formed around many diseases such as liver disease, cardiovascular disease, metabolism, ophthalmology and rare diseases.

  Shenxin biology Focus on the development of preventive and therapeutic mRNA vaccines and drugs. Nearly 5000 LNP libraries have been constructed, and LNP vectors suitable for different treatment scenarios have been screened, which has created excellent conditions for the continuous research and development of mRNA product pipelines. With its leading LNP delivery technology platform, we firmly believe that biology has built research and development pipelines in four major directions: infectious diseases, rare diseases, tumor therapeutic vaccines and tumor immunotherapy enhancers.