标签归档 西安夜生活网

通过admin

The latest price of Jinan BMW i5 car is 328,000 yuan, and the news of price reduction is discounted. The latest offer is 111,900 yuan, and the car is sufficient.

[car home Jinan Preferential Promotion Channel] Special attention! Good news! This high-profile model is enjoying a grand preferential activity in Jinan area. At present, car buyers have the opportunity to enjoy an attractive discount of up to 111,900 yuan, which further reduces the original minimum starting price of 328,000 yuan. This undoubtedly brings attractive car buying opportunities to consumers in Jinan. If you are interested in BMW i5, don’t miss this once-in-a-lifetime opportunity to reduce the price. Click "Check the car price" in the quotation form immediately, and take the time to get a higher discount!

济南宝马i5汽车最新价格32.8万,大幅降价打折,最新报价优惠11.19万,现车充足

As an innovative electric vehicle, BMW i5 shows a futuristic design. The front face adopts the BMW family’s iconic kidney-shaped air intake grille, but incorporates the characteristic elements of new energy vehicles, such as closed design to emphasize its electric identity. The body lines are smooth, and the overall style is very scientific and sporty, which combines elegance and strength, highlighting BMW’s unique understanding of luxury electric vehicles.

济南宝马i5汽车最新价格32.8万,大幅降价打折,最新报价优惠11.19万,现车充足

With its dynamic body design, BMW i5 shows an elegant and powerful profile. In terms of body size, it has a length of 5175mm, a width of 1900mm and a height of 1520mm, which gives it spacious interior space and stable body proportion. The wheelbase is as long as 3105mm, which further improves the ride comfort. The front tread of 1621mm and the rear tread of 1658mm ensure good driving stability. Tyre size is 245/45 R19, with exquisite rim design, which not only enhances the visual effect, but also ensures the excellent performance of driving performance.

济南宝马i5汽车最新价格32.8万,大幅降价打折,最新报价优惠11.19万,现车充足

The interior design of BMW i5 shows the perfect combination of luxury and technology. Exquisite leather steering wheel not only provides a comfortable grip, but also supports electric up and down+front and rear adjustment, so that drivers can adjust the best driving position according to their needs. The 14.9-inch central control screen stands in the center, equipped with advanced speech recognition control system, which can easily control various functions such as multimedia, navigation, telephone and air conditioning. The seat is made of imitation leather, which ensures the riding comfort. The main and auxiliary seats support multi-directional adjustment, including front and rear, backrest, height and lumbar support. The front seats also provide additional heating function. In addition, the vehicle is equipped with USB/Type-C interfaces, including two in the front row and two in the back row, and the wireless charging function of the mobile phone, which fully meets the daily needs of passengers.

济南宝马i5汽车最新价格32.8万,大幅降价打折,最新报价优惠11.19万,现车充足

BMW i5 is equipped with an efficient engine with a maximum power of 210kW, and its powerful power output can satisfy the driver’s pursuit of performance. In terms of torque, this engine provides a torque of 410 Nm, which makes the vehicle show strong torque support during acceleration and driving, ensuring a smooth driving experience and excellent performance.

In summing up the owner’s comments, BMW i5 won his love with its eye-catching front design and unique sense of movement. He said that the appearance is very attractive, especially the heavy lines and good face value, which undoubtedly added extra charm to the driving experience. For drivers who are looking for appearance and performance, BMW i5 is undoubtedly a worthy choice.

通过admin

Love, Death and Robots marks the arrival of the era of customized entertainment?

  Still photos of Love, Death and Robots.

  Netflix’s new animated series "Love, Death and Robots" (hereinafter referred to as "Love Crashes") contains sci-fi, fantasy, horror and comedy, which combines the animation forms of 2D and CG short films. The story is short but often unexpected, and the whole series is full of cult temperament, which has quickly gained a large number of adult animation fans. The production team of "Love Crash" has film and television producers and teams from Hollywood, and there are many independent producers. The whimsy of different styles collide with novel sparks in the same drama, which is hard to imagine in mainstream film and television dominated by big studios. Naifei, the publisher of this drama, is an internet media company that has developed rapidly in recent years, and it is reconstructing the future digital entertainment map in its own way.

  Netflix, once a film and television rental company, has made great strides in the field of film and television production and distribution in recent years, and produced and distributed a series of influential works exclusively, including masterpieces such as House of Cards and Oscar-winning film Rome, which greatly challenged and even shook the foundation of the mainstream film and television industry. Behind this expansion momentum, the first is Netflix’s high investment. The company’s latest financial report shows that in 2018, the content expenditure exceeded the $10 billion mark for the first time, reaching an astonishing $12 billion. Netflix not only dares to buy drama series, but also provides advance payment for upstream film and television producers, covering all the film and television projects. Nowadays, Internet film and television is a competitive market, and a new Internet film and television giant like Amazon threatens Netflix at any time. Therefore, it has become Netflix’s strategy to acquire film and television resources and market share on a large scale through high investment.

  Still photos of Love, Death and Robots.

  Secondly, compared with traditional studios, Netflix respects professionalism and encourages creative freedom, and does not directly interfere with content production, thus giving filmmakers and partner companies more free expression space. Netflix has increasingly become a platform-based company that directly connects film producers and audiences, so much so that kevinspacey fowler, who starred in House of Cards, once lamented that Netflix wanted to "go directly from script to DVD". Netflix also tends to cooperate with independent filmmakers, fully explore Hollywood resources, and make high-quality products with more easily available resources. The most unique feature of Netflix lies in its big data operation mode, which analyzes big data through the user data of the streaming media platform, such as what content is the most popular, and then takes it as the decision-making basis for production and accurate sales. The result of this content production method is that the user’s taste determines the final product. There is every reason to believe that Netflix will test the audience popularity of various artistic expressions in Love Crash, or that the setting of 15 minutes per episode is also the best result obtained by Netflix through big data? If you ask who will know the audience’s taste best in the future, it may be a digital distribution platform like Netflix, which can master the detailed portraits of the audience. It is these characteristics of Netflix that make the content style diverse, and the novel "Love Crash" became possible.

  Still photos of Love, Death and Robots.

  From the content to the form, we can see that "Love Crashes" tries to show the face of a new digital entertainment industry, and it is Netflix’s ambition to build the industrial chain of this new entertainment industry. In terms of content, the title of the whole work "Love, Death and Robots" has already told us about the most fundamental problems of human beings and Cyberpunk. The core of most dramas is inseparable from sexual pornography, death violence and subversion of robots. This way of catching fans’ eyes is in the same strain as the entertainment industry in the past, and its style inspiration comes directly from the magazine Heavy Metal and its adaptation of the same name, which is also a collection of animated films full of sex and violence. Similar to "Heavy Metal", the drama presents the classic fantasy novel text and different visual forms to the audience, so that the audience will not get bored in the pleasure of watching movies. Some critics say that the core of the play is covered up by sensory stimulation, especially in the current situation that the American literary and art circle is left-sided, the materialized content of women in the play will inevitably lead to controversy. However, the producer’s cleverness lies in that it accurately grasps the audience’s entertainment "highlights", at the same time, it compresses the huge original text information into a short space adapted to the Internet era, presents the essence of the classic text, and allows the audience to enjoy the fun of self-exploration of the text content.

  Formally, we can see that what Netflix is trying to create is a new film and television experience that allows the audience to participate.

  Symbols of the title of Love, Death and Robots.

  The logo of "Love, Death and Robot" is made into a visual symbol logo similar to a gambling machine, which has a high degree of symbol recognition. If you look closely at the title of each episode, you can see that the symbol of the title of "Love, Death and Robots" will also change with the content of each episode. For example, the first episode is the heart and fork representing "love and death" plus a snake totem representing the protagonist’s team. In the second episode, it becomes two robots plus a hamburger representing robot cognition. In the third episode, the symbol is a snake biting its tail, a prostitute’s head wearing a gel coat and an eye implying a witness. These symbols not only echo the plot, but also give the audience the illusion of free and random choice. In theory, the audience can really enter the world of Love Crash from any episode.

  Netflix obviously thinks that the viewing order will also affect the audience’s experience, so he provides four different playing orders for the audience, saying that it is only for A/B detection, and does not involve user big data and machine learning prediction. Lucas Thomes, the founder of Out in Tech, an LGBT organization, is worried that this kind of broadcast form will play stories involving homosexual content first for the same-sex audience and heterosexual content first for the opposite-sex audience, in order to obtain higher user satisfaction and subscriptions. Once this form is combined with technical means such as machine learning, it is conceivable that the identity of the audience will solidify its viewing experience, and the so-called free experience will exist in name only.

  Still photos of Love, Death and Robots.

  In another drama series "Black Mirror: Pandasnaki" produced by Netflix, the audience can choose the protagonist in the film, thus affecting the development of the plot and even interacting with the characters in the play. Just like the random freedom of Love Crash, the audience can enter from any plot, and different choices will bring different endings. However, all the plots can happen cyclically, so that the audience can experience their own personalized world in their own choices. Coincidentally, an entertainment giant like Sony also launched a interactive movie game like Detroit: Transformers, where players can explore the plot by choosing characters on their own console platform. If interactive movie is essentially an upgraded version of interactive games in the past, what Netflix should do is to be an interactive game platform provider in the Internet era, and bring interactive entertainment into the digital era with the help of its movie copyright and big data technology. Maybe in the near future, we will see a sequel to Love Crash that can choose the plot.

  With the development of digital Internet, it is expected that the movie and television entertainment industry will further develop rapidly in terms of big data customization in content and free choice in watching movies, which will also lead to profound changes and reconstruction in the entire entertainment industry. Love Crash represents such a trend, that is, the arrival of the era of entertainment customization. With the increasingly accurate operation of big data, the audience will be directly connected with the mainstream film and television industry, and everyone can get a customized version of film and television entertainment. At the same time, the digital platform will also gather freelancers to make the collective creation of film and television works more efficient and convenient. More importantly, the improvement of the audience’s choice in the works also liberates the expressive ability of film and television works. Different interpretations brought by different plots will make the works more open and generate more audience feedback, so as to further improve the works.

  Still photos of Love, Death and Robots.

  There are also some worrying social problems in this emerging entertainment mode. In addition to the privacy and even identity discrimination that big data operation may bring, more importantly, it is likely to aggravate the tribalization tendency of today’s society. Social media such as Facebook has brought about the "tribalization" of users’ personal socialization, which has led many users to only see the opinions of people in their own groups, thus strengthening the division of American society. Customized entertainment products and big data marketing will naturally aggravate this situation in the cultural industry, and the audience’s own sense of identity and belonging will continue to be strengthened and even completely solidified, making the threat of cultural war go deep into the literary and art circles. These problems need to be corrected and avoided by the entertainment industry, but examples like Facebook tell us that it is often just wishful thinking to expect Internet giants to come from me.

通过admin

Four responsibilities in the eyes of the supreme leader

  It is the spiritual demeanor and lofty realm of contemporary the Communist Party of China (CPC) people to shoulder the responsibility. Since the 18th National Congress of the Communist Party of China, the general secretary of the Supreme Leader’s many speeches and articles have always run through his responsibility for the destiny of the nation, the happiness of the people, the management of the party and the beautiful world. The micro-platform of Party Construction Network will learn and understand with you.

  Responsibility for the destiny of the nation

  Remain true to our original aspiration and keep our mission firmly in mind. The Communist Party of China (CPC) people’s initial intention and mission is to seek happiness for the people of China and the rejuvenation of the Chinese nation. This initial intention and mission is the fundamental driving force to inspire the Communist Party of China (CPC) people to keep moving forward. Comrades of the whole party must always share the same breath with the people, share the same destiny and be heart-to-heart, always take the people’s yearning for a better life as their goal, and continue to forge ahead courageously towards the grand goal of realizing the great rejuvenation of the Chinese nation with a never-ending mental state and an indomitable attitude.

  — — On October 18, 2017, the report of the Supreme Leader at the The 19th National Congress of the Communist Party of China.

  The energy saved by the Chinese nation has been too long, and it will burst out to realize the great Chinese dream. This is the historical mission of our generation, and each of us is striving to achieve this goal in our own posts.

  — — On July 19, 2016, the Supreme Leader emphasized during his inspection in Ningxia.

  The Communist Party of China (CPC), born and raised in the midst of internal troubles and foreign invasion, has made it its historical mission to realize the great rejuvenation of the Chinese nation since its establishment. It is the steadiest in defending national independence, the steadiest in safeguarding national interests and the bravest in resisting foreign aggression.

  — — On September 3, 2014, the Supreme Leader’s speech at the symposium to commemorate the 69th anniversary of the victory of China people’s War of Resistance against Japanese Aggression and the world anti-fascist war.

  Responsibility for people’s happiness

  We must seek more benefits for people’s livelihood, solve more worries about people’s livelihood, fill the shortcomings of people’s livelihood in development, promote social fairness and justice, make continuous progress in providing education for young children, learning and teaching, earning income from work, getting medical care for the elderly, living and living, and helping the weak, and carry out in-depth poverty alleviation to ensure that all people have more sense of gain in building and sharing development, and constantly promote the all-round development of people and the common prosperity of all people.

  — — On October 18, 2017, the report of the Supreme Leader at the The 19th National Congress of the Communist Party of China.

  Leading the people to create a happy life is our party’s unswerving goal. We should conform to the people’s yearning for a better life, adhere to the people-centered development idea, focus on safeguarding and improving people’s livelihood, develop various social undertakings, increase the adjustment of income distribution, win the tough battle against poverty, ensure people’s equal participation and equal development rights, make the fruits of reform and development benefit all people more fairly, and make steady progress towards the goal of realizing common prosperity for all people.

  — — On July 1, 2016, the Supreme Leader’s speech at the celebration of the 95th anniversary of the founding of the Communist Party of China (CPC).

  The Communist Party of China (CPC) insists on governing for the people, and people’s yearning for a better life is our goal. My ruling philosophy, in a nutshell, is: serving the people and shouldering the responsibility.

  — — On February 7, 2014, the Supreme Leader spoke in an exclusive interview with Russian TV in Sochi, Russia

  Take responsibility for managing the party.

  Courage in self-revolution and strict management of the party are the most distinctive characters of our party, and strict management of the party in an all-round way is always on the road.

  — — On January 5, 2018, the Supreme Leader emphasized at the opening ceremony of the seminar on the study and implementation of Socialism with Chinese characteristics Thought of the Supreme Leader in the New Era and the spirit of the 19 th National Congress of the Communist Party of China by members and alternate members of the new Central Committee and leading cadres at the provincial and ministerial levels.

  Strictly administering the party in an all-round way is always on the road. Party organizations at all levels should shoulder the responsibility of strictly administering the party in an all-round way. To strictly manage the party in an all-round way, the core is to strengthen the party’s leadership, the foundation is comprehensive, the key is strict, and the key is governance.

  — — On January 12, 2016, the Supreme Leader delivered an important speech at the Sixth Plenary Session of the 18th Central Commission for Discipline Inspection.

  From the height of the life and death of the party and the country, our party promotes the building of a clean and honest party style and the struggle against corruption with a strong sense of historical responsibility, a deep sense of mission anxiety and tenacious will, adheres to no-forbidden zone, full coverage and zero tolerance, severely investigates and punishes corrupt elements, and strives to create a political atmosphere that does not dare to rot, cannot rot and does not want to rot.

  — — Speech by the Supreme Leader at the Fifth Plenary Session of the 18th Central Commission for Discipline Inspection on January 13th, 2015

  The more glorious the historical mission is, the more ambitious the goal is, and the more complicated the ruling environment is, the more we must enhance our sense of hardship, the more we must strictly manage the party, and achieve "doing what is not, managing what is not chaotic" so that our party will always be in an invincible position.

  — — On October 8, 2014, the Supreme Leader’s Speech at the Summary Meeting of the Party’s Mass Line Education Practice Activities

  Responsibility for a better world

  The Communist Party of China (CPC) is a party that strives for happiness for the people of China, and also strives for the cause of human progress. The Communist Party of China (CPC) is the largest political party in the world. As I said, if you are big, you have to look big. Everything that the Communist Party of China (CPC) has done is to seek happiness for the people of China, the rejuvenation of the Chinese nation, and peace and development for mankind.

  — — On December 1, 2017, the top leader delivered a keynote speech at the high-level dialogue meeting between the Communist Party of China (CPC) and the world political parties.

  We must co-ordinate the two overall situations at home and abroad, unswervingly follow the path of peaceful development, pursue an open strategy of mutual benefit and win-win, adhere to the correct concept of justice and benefit, establish a new security concept of common, comprehensive, cooperative and sustainable, seek open, innovative, inclusive and mutually beneficial development prospects, promote civilized exchanges that are harmonious but different and eclectic, build an ecological system that respects nature and green development, and always be a builder of world peace, a contributor to global development and a defender of the international order.

  — — On October 18, 2017, the report of the Supreme Leader at the The 19th National Congress of the Communist Party of China.

  China will continue to actively participate in the reform and construction of the global governance system, contribute more China wisdom, China’s plan and China’s strength to the world, and promote the construction of a world of lasting peace, universal security, common prosperity, openness, tolerance, cleanliness and beauty, so that the sunshine of building a community of human destiny can shine all over the world!

  — — Speech by the Supreme Leader at the First Session of the 13th National People’s Congress on March 20, 2018.

  (For some information, refer to the book Thirty Lectures on Socialism with Chinese characteristics Thought of the Supreme Leader in the New Era.)

通过admin

Climate and dining table | What should we do if the happiness of coffee and chocolate is gone?

The scorching summer has come, and other creatures on the earth are also suffering from high temperature besides human beings. You may not realize that the ingredients that are about to become delicious food in your mouth are also in danger of "heatstroke". For example, refreshing coffee, cool orange juice and sweet chocolate. The book "The Earth Doesn’t Care: The Table Destroyed by Climate Change" shows readers an unknown global food picture, and those foods that we are used to may become increasingly scarce in the future. 

The earth doesn’t care: the dining table destroyed by climate change

Coffee that continues to reduce production.

Since 2010, the global coffee bean production has been declining, because the main coffee producing areas are located in Africa and Brazil, where the temperature is rising, especially the temperature difference between day and night is getting smaller and smaller, which directly affects the growth of coffee trees, and coffee gardens have to move to higher altitudes.

Some studies have predicted that Arabica coffee, the queen of coffee today, will be severely hit in the future. The optimal growth temperature of this coffee bean is between 18 and 24 degrees Celsius. If the temperature exceeds 30 degrees Celsius for a long time, its growth will stagnate.

Arabica coffee

In addition, there are more and more extreme climates. The high temperature scorches the coffee leaves, and the rising air humidity will cause more pests and diseases, such as a terrible fungus, Camellia sinensis. These effects not only reduce the yield of coffee beans, but also increase the price of coffee.

The book points out that if you want to continue drinking coffee, you need to change the coffee planting system. For example, choosing a coffee tree species that is more adaptable to changes requires farmers to pull out the old varieties of coffee trees. Some professors joked that "it is not so simple as separating a man from his wife".

For another example, coffee farmers should learn more sustainable planting methods, including improving soil, mixed planting, setting up cooperatives and so on. However, the change of agricultural production can not be achieved overnight, and it needs long-term experience accumulation, but also needs various considerations of social economy. I am afraid that the progress of human-made change can not keep up with the speed of environmental change.

Therefore, the author still pessimistically points out that in the future, only those who can still afford high-priced coffee can casually promise "Let’s have a cup of coffee!" For ordinary people, one day in the future, they may have to give up the leisure hobby of coffee.

Oranges plagued by plague

80% of the concentrated orange juice in the world comes from Brazil. However, a plague, Huanglongbing, broke out in orange plantations in Brazil. For oranges, Huanglongbing is just like Covid-19’s threat to human beings. The plague has swept the world, and it is constantly mutating in the process of spreading. According to FAO data, Huanglongbing has destroyed more than 100 million orange trees worldwide.

Citrus trees with Huanglongbing disease

The pathogen of Huanglongbing first lived in the hot environment of Asia, and was first discovered by farmers in Chaozhou, China hundreds of years ago. In 1965, the pathogen was found in southern Africa. Two years later, experts found its trace in the Philippines, and the pathogen and citrus psyllid combined to form a more harmful disease. In 2004, the disease also appeared in Brazil, and a new bacterial variety was produced, which began to sweep the whole America.

This plague will spread from orange tree to orange tree. When they are infected, they will give off the fragrance of methyl salicylate, attract a large number of psyllids, and further spread the disease. The researchers pointed out that with the increase of temperature, the reproduction speed of psyllid can be increased from 4 generations to 8 generations per year.

Huanglongbing not only leads to the decline of orange yield, but also makes the taste of fruit sour. In other words, orange juice is not as good as it used to be, and the composition of juice must be redesigned. This has brought new challenges to the orange juice industry.

Like human beings, solving the plague problem requires a high cost. In fact, except oranges, many crops are facing the same disease disaster problem. It is also mentioned in the book that vineyards in Europe are being harmed by a fruit fly, and olive trees are also being harmed by another fruit fly.

More and more "luxury" chocolate

Cocoa trees generally grow between 20 degrees north latitude and 20 degrees south latitude. Cocoa beans produced in C? te d ‘Ivoire and Ghana in western Africa meet the demand of two-thirds of the world cocoa bean market. With the climate change, the local rainfall is getting less and less, and cocoa trees can’t stand the long-term high temperature and dry climate. The optimum growth temperature of cocoa trees is 21-32 degrees Celsius, which can withstand the high temperature of 36 degrees Celsius for a short time. Once the temperature is exceeded for too long, the cocoa trees will suffer from "heatstroke". If there is not enough water to cool down, their own circulation system will soon collapse.

cacao tree

According to the research report "Vulnerability of Cocoa Trees in West Africa to Climate Change", the whole West Africa cocoa will be brought to the middle of the 21st century, and 50% of the planting area will disappear due to high temperature and heat. In 2016, The Wall Street Journal speculated that the chocolate industry had invested about $1 billion to develop measures to deal with climate change.

Edward George, an agricultural expert, said: "Maybe one day, chocolate will really become a luxury like champagne in Europe, and it is no longer something that ordinary people like us can easily imagine."

In fact, like coffee trees, orange trees and cocoa trees, most agricultural products planted by human beings are facing the same dilemma, with less and less water resources, more and more harsh living conditions for plants and more and more pests and diseases. At the same time, the global population is still growing, and the demand for food is increasing. In the future when climate change is getting worse, it may become more and more difficult for human beings to fill their stomachs.

Casino dice

In order to solve the food problem, we must have a deep understanding of the most serious problem facing mankind-climate change. However, in the view of William .Nordhaus, the winner of the Nobel Prize in Economics in 2018, the agricultural problems concerned in The Earth Doesn’t Care: The Table Destroyed by Climate Change are still controlled systems under the influence of climate change, which can be solved by scientific and technological means. That is to say, it is still possible to make crops grow in a completely artificial environment, and of course the cost will be high.

Global warming, storm sea level rise.

Nordhaus classified the impacts of climate change into two categories, and the uncontrolled system is more terrible than the controlled system. Uncontrolled systems include sea level rise, ocean acidification, the intensification of hurricanes and the loss of ecosystems, and their operation is basically free from human intervention. Take ocean acidification as an example. Although some people still question global warming, there is basically no debate about ocean acidification, because it can be verified by simply measuring pH value. Ocean acidification will seriously affect fisheries, and oysters, corals, plankton and shellfish will be affected. Scientists’ research on this topic first appeared in 2004, and it is still in the initial research stage, so no solution has been put forward.

In the public’s cognition, climate change is still too far away. Although extreme weather such as high temperature, drought and rainstorm are becoming more and more frequent, the public still can’t directly understand the impact of climate change on themselves. Some people even think that natural scientists pay too much attention to environmental protection and fail to consider the needs of economic and social development.

Climate Casino: Risk, Uncertainty and Economics of Global Warming

If you feel the same way, nordhaus’s "Climate Casino: Risk, Uncertainty and Economics of Global Warming" will give you a new perspective to understand climate change. As the author’s metaphor in the title of this book shows, human beings are entering the "climate casino" and throwing some climate dice, some of which may be dangerous. So, what can gamblers do in casinos? First of all, we need to know the consequences of different dice to help us get out of the casino safely.

How much will it cost to mitigate climate change?

This popular science book introduces the economic policies to deal with climate change. The most important thing is that the author always discusses the possible economic impact of climate change from the perspective of "cost and benefit", so that readers can understand that climate change is actually an economic problem.

Nordhaus believes that there are three main ways to deal with the threat of climate change.

The first method is adaptation, which means that we should learn to cope with the warming world, not stop it. This method is highly praised by people who think that climate change is negligible. But the problem is that the economic cost of adaptation is not low. If the investment in agricultural facilities is acceptable, then the investment in dealing with sea level rise may be astronomical. Therefore, the general view of experts at present is that adaptation is local and prevention is global.

The second method is geo-engineering, which is generally divided into two categories. The first category is the technology of removing carbon dioxide from the atmosphere, and the second category is the solar radiation management technology that reflects sunlight and heat back into space. But the problem is that geoengineering can not completely offset the greenhouse effect on the technical level; On the implementation level, geo-engineering is a double-edged sword, which has a certain constructive role, but at the same time it is potentially destructive. It can be used in good faith or for malicious destruction. Therefore, the author believes that geo-engineering is similar to what doctors call "rescue therapy" and can only be used when other schemes fail.

The third method is to slow down (prevent) climate change, that is, to take action to reduce greenhouse gas emissions and reduce its atmospheric concentration. This is the focus of current global consultations, and it is the safest solution from the environmental point of view. The author thinks that although it is the most expensive to slow down climate change in the short term, it is actually the most economical way in the long term.

Reduce greenhouse gas emissions

Through the calculation of economic model, nordhaus found that if we live in an ideal world-all countries in this world coordinate and jointly launch emission reduction measures, earnestly ensure that all countries and departments participate, and act in a timely and efficient manner. Then, it is feasible to achieve the goal of "2-degree temperature rise ceiling" proposed by Copenhagen agreement, and it only needs to spend 1%-2% of the world’s total income every year.

However, such a world does not exist. Because "reliable and correct, it may not be popular and realized, and even in reality, it will be fiercely resisted."

Through the economic model, nordhaus found that if only half of the countries participated in the efforts, it would not only be much more expensive, but also impossible. In addition, inefficient control or methods will also double the cost. Therefore, mankind still needs to strive to develop more efficient technologies, design social mechanisms to promote economic efficiency and high participation rate, and provide help to poor countries with limited resources. Finally, we may need to adjust our goals so that they can be achieved.

Obviously, the goal of the upper limit of 1.5 degrees has become increasingly difficult to achieve. On May 17th this year, the World Meteorological Organization (WMO) released the latest report, saying that the global temperature may rise to a record high in the next five years, and it is very likely that it will briefly break through the threshold of 1.5 degrees Celsius, one of the key indicators of global warming stipulated in the Paris Agreement.

How much do you have to pay for carbon emissions?

See here, you should probably understand why many countries have put forward the goal of carbon neutrality, and China also put forward the goal of "carbon neutrality in peak carbon dioxide emissions in 2030 and in 2060" in 2021. You may also understand that what so many international climate conferences are discussing is actually urging all countries to make commitments and take practical actions. Because this is the only choice for mankind at present.

So, for ordinary people, what do you have to pay for it?

On the economic level, nordhaus proposed two ways, one is carbon tax, and the other is carbon trading. Simply put, it is to set a price for carbon emissions, and then let enterprises or consumers pay for it in different ways. In fact, this has already appeared in our daily life, such as the familiar fuel tax. He pointed out that even the most conservative economists support carbon tax as the most efficient way to slow down global warming.

However, in the policies of different countries, nordhaus believes that many control policies are inefficient or ineffective, with little impact, but they need to spend huge costs. For example, subsidies for green technologies provide financial incentives for solar energy and hybrid vehicles. Nordhaus raised his own question, why should we subsidize hybrid cars instead of bicycles? Subsidies are not the solution. It is much more practical to punish carbon emissions than subsidies.

Another thing to note is "energy-cost shortsightedness", that is, we may buy cars with lower initial cost in order to save money now, and underestimate the energy saved in the future. Failure to make the most economical decision is a common feature of human behavior, and human shortsightedness can only see immediate interests. To put it mildly, this is why some low-carbon behaviors are difficult to promote; To put it bluntly, this is the reason why human beings have come to this situation today.

Don’t be a slave to money.

Looking at climate change from an economic perspective will make the analysis and discussion more rational, and of course it will ignore other important contents. After all, money can’t solve all problems. Capitalism in Lishan: Don’t be a slave of money, be a master of Lishan with peace of mind, which is a collection of cases that can broaden one’s horizons and provide innovative solutions.

Capitalism in Lishan: Don’t Be a Slave of Money, Be a Secure Master of Lishan.

This book is based on a series of investigation reports produced by NHK after the 311 earthquake in Japan. They found some alternative economic models and coined the term "Rishan Capitalism" together with the economist Hirosuke Noguchi.

They believe that "money capitalism" is built on the premise that the circulation of funds determines everything, while "Lishan capitalism" quietly establishes a subsystem that does not depend on money next to "money capitalism", allowing people to continuously obtain water, food and fuel when they have no money. Because what people need to survive is water, food and fuel, not just money.

"Lishan capitalism" is a reflection on natural disasters that human beings can’t cope with, and it is also a reflection on the global economic system. The place was originally only a part of the global economic industrial chain, and even a party eliminated by fierce competition. If we can get rid of the inertia thinking mode of "money capitalism", re-examine the local resources and advantages, and even look at the existing problems with reverse thinking, we may find new treasures. The book introduces some interesting cases of "turning waste into treasure".

Energy revolution town

Zhenting City, Okayama Prefecture has carried out the most advanced energy revolution in Japan. The local economy is supported by forestry and wood processing industry. At the end of 1997, the local wood processing factory began to use sawdust to generate electricity, which was called "woody biomass power generation". Sawdust was originally the production waste of the factory, and it needs to be treated as industrial waste, which costs a lot of money. However, since the start of power generation, the power consumption of the factory has been almost 100% dependent on biomass power generation, which has also saved the power consumption cost, which is a typical innovation of turning waste into treasure.

Because of the excessive sawdust waste, the local factory thought of a new use, pressing it into "wood particles" and becoming a new fuel, which can be used by local families and agricultural boilers. Since then, this small town has begun to build a biomass industry and ushered in economic recovery.

In 2022, the European Parliament continued to recognize "original woody biomass" as renewable energy. In fact, Austria is the most advanced country in "power generation from woody biomass". The author of this book also went to Austria for an interview and found that, like Zhenting, a small town in Japan, energy conversion not only solved the energy problem, improved the energy self-sufficiency rate, but also promoted the local economic regeneration and even enhanced national security.

Overcome the lack of society

Aging and declining birthrate are making Japan a "society without opportunities", that is, a society in which people lose contact. There are many vacant houses and elderly people in Zhuangyuan City, Hiroshima Prefecture. The local "Overpopulation Inversion Association" is conducting some welfare experiments on how to turn the problem into resources. They believe that "the disadvantage is not a defect but a treasure chest". Community currency is an interesting attempt.

The staff of the "Overpopulation Inversion Association" heard when chatting with some day-care elderly people that some elderly people like to grow vegetables at home, and they can be self-sufficient, and there will be many vegetables left rotting in the ground, which makes the elderly feel very distressed. So they thought of a way. All the ingredients in the local welfare homes are purchased from foreign real estate. If you buy the dishes of the elderly in the form of community currency, it will not reduce food waste. In the end, the welfare home bought the dishes for the elderly at half the market price, and the elderly could pay for day care with community currency, achieving a win-win situation.

Later, a local restaurant that can use community currency was opened, and a nursery park was opened next to it. The ingredients in the restaurant come from the vegetable garden of the local elderly, and the staff is the mother who is raising children. After sending the children, they can start working. Old people can have lunch in the restaurant or play with the children in the nursery.

Community currency returns to the original function of currency-exchange value, and at the same time undertakes the function of rebuilding local interpersonal connection. People can exchange and communicate with resources and skills that cannot enter the market, especially those who are usually considered as the weak in society, including the elderly, the disabled and housewives.

summarize

In the economic model of Nobel Prize economist nordhaus, we understand why we should reduce carbon emissions to deal with climate change, because it is the only rational choice for human beings. Only along this road, those foods we love can last longer. However, this road is full of thorns, because many problems of "money capitalism" have accumulated. At this time, we need to change some ways of thinking, just like the solution of "Lishan capitalism".

"The insurance premium of Lishan capitalism is not money, but to act and prepare for the matter itself."

For ordinary people, climate change is a problem that we can’t solve with money, but we can use "action and preparation" to win more insurance for ourselves. Preparation comes from our understanding of climate change; Action comes from the change of our daily behavior.

People share the food on the table.

In a recent sustainable food workshop, I shared some information about endangered foods with the participants. I just told them which foods might disappear, and I didn’t have time to introduce the story "The Earth doesn’t care: the table destroyed by climate change" in detail. Even so, when people know that coffee and chocolate may become increasingly scarce, they have shown their frustration that happiness will be deprived.

Perhaps such depression is the seed of "action and preparation". In the face of an uncertain future, we cannot underestimate the impact of climate change, nor can we underestimate the potential of individual action.

通过admin

The 90-year-old couple has been doing good for more than 30 years: "We want to contribute waste heat to the country."

 Pang Lizhi and Bai Zuxun

Pang Lizhi and Bai Zuxun

Thank-you letter written by children to parents.

Thank-you letter written by children to parents.

Letter of thanks from parents.

  From the day nanny Wang Xiulian went to work, 92-year-old grandfather Bai Zuxun told her, "You should be prepared to accompany me to do charity." Looking at the gray-haired grandfather in front of him, Wang Xiulian couldn’t believe it. With the poor health "imprisoning" Bai Zuxun and his wife’s actions, they felt a little lost. But staying in the ward, the old couple have been thinking: How can we help others? A month and a half ago, 92-year-old Bai Zuxun and 91-year-old wife Pang Lizhi posted a handwritten proposal in black and red at the entrance of Jiulidi North Road Community, which read: Bai Zuxun and his wife Pang Lizhi jointly decided to send rice and oil to 100 needy households in poverty-stricken areas during the Spring Festival, and delivered them to the community in a centralized and unified manner.

  I heard that five families have responded, and the old couple are very happy about it. Bai Zuxun said: If there are not enough households responding to the initiative, we will pay the money. Asked why they are not rich enough to help others, they replied: "We help them, they are young and promising, and we are getting older every day. Helping them is stronger than helping us, which also represents our strength." Chengdu Business Daily-Red Star Journalist Hu Ting Zhang Ling Photo Report

  An unforgettable childhood memory

  I have experienced War of Resistance against Japanese Aggression, "We want to contribute waste heat to the country."

  In a hospital in jinniu district, the reporter met Bai Zuxun and Pang Lizhi. Grandma Pang is taking oxygen because of poor lung function. The reporter shouted twice, but Grandpa Bai didn’t respond. Grandma Pang said that his ears were not very good. As they get older, their parents feel that their health is worse than before. When talking about the charity that has recently fallen behind, Grandma Pang said: If they live for a few more decades, they can do more.

  The two old people were born around 1927. At that time, the society was in turmoil, which made them experience many hardships.

  Pang Lizhi is a native of Nanjing, Jiangsu Province. When she was 10 years old, she escaped by hiding in the cabin because of the outbreak of War of Resistance against Japanese Aggression. Just three days after she left Nanjing, Nanjing fell and saw many people being displaced and losing their lives. At that time, she thought, we need a strong country.

  Later, life became better and better, and they always held a belief: "We should do our best to contribute our waste heat to the country."

  A box full of thank-you notes

  Helping others for many years, "not icing on the cake, just giving charcoal in the snow"

  After more than 30 years of retirement, they have saved money on pensions and peacetime, helping six students finish their studies, spontaneously sending medicines to people in need, and sending warmth to low-income households … … The box at the head of Bai Zuxun’s hospital bed is neatly filled with thank-you letters written by the grantees.

  "Dear grandparents, hello! I have made progress. Although I have made little progress, I am still very happy … … I believe that if you pay, you will get something. " "We are all very grateful for your support for our sisters, and we will use our efforts to repay your help." "Grandparents, the weather has turned cold recently, so be careful not to catch a cold … …” As soon as they have time, the parents will read it out — — For more than 30 years, some people still remember their names, while others can’t.

  In 1994, Er Lao opened a kindergarten in Xindu, where children from poor families were admitted free of charge. Knowing that many local students from poor families can’t go to school because of family difficulties, they offered to subsidize their studies. When I saw the letter, my memories slowly came to me. "A pair of twin sisters went to 1000 yuan every month to help them finish high school smoothly, and funded Zhao Siyu’s classmate 400 yuan, stationery and so on … …”

  Bai Zuxun said that in doing charity, they have a principle: not icing on the cake, just giving charcoal in the snow. They don’t need others to repay them. Sometimes, people who have been sponsored by them want to contact them through their children, and they are also declined: "We are willing to help them, so these are unnecessary."

  A blue shirt with white clothes.

  Be generous to others and "dig" yourself, and go to several vegetable markets to buy cheap food.

  For more than 30 years, they have donated money to help students and others, and they can’t remember how much they spent. But as long as they have a little spare money, they are willing to take it out for charity. According to nanny Wang Xiulian, "They are generous in helping others, but frugal in themselves. Leftovers should also be kept and eaten. In order to buy cheap dishes, we must visit several vegetable markets. " In Grandpa Bai’s wardrobe, many clothes have been worn out, and I still can’t bear to throw them away. I have worn a blue shirt for decades, and the blue is slowly turning white, and I don’t care. There are also many people who advise them that they could have lived well with retirement wages after retirement. "Why bother?" Bai Zuxun said, "Our requirements are not high, and it is right to guarantee a basic life."

  Grandma Pang said that she never dreamed of living in her 90 s. She guessed that it may also be because she has been doing good deeds. "I wake up every day thinking about how to help others. With that mood, my mood will be very happy."

  Hu Min, director of Jiulidi North Road Community Neighborhood Committee, told the reporter that she didn’t know their deeds until the two old people moved from Xindu to Jiulidi. "The two old people are very famous in Xindu. After coming to Jiulidi, the charity has been going on, visiting low-income households, donating money to community funds and donating money to schools. Bai Zuxun himself has rheumatism, so he bought medicine for some residents suffering from the same disease. " Hu Min said that they have always had a good reputation in their jurisdiction, and Bai Zuxun also won the title of the first "Top Ten Good People in the Community" in the community. Hu Min said, "Their kindness is very worthy of our study and promotion."

  Old couple’s family situation

  The 70th anniversary of the founding of New China is approaching in anniversary.

  "Twenty years earlier, I really want to go to Beijing for a walk."

  Grandma Pang likes watching the news very much. Seeing the five-star red flag flying on the world stage, "I’m so happy." In their view, what they do is not great, but they just want to contribute to the strength of the country. "Help others, and those who are helped will help more people. The strength of a country cannot be achieved by the strength of a few people alone. If everyone has this awareness, then our country must be strong! "

  In a few days, anniversary will be the 70th anniversary of the founding of New China. Looking at such a powerful motherland now, the parents are very excited. "We can’t go far now. If we can go 20 years earlier, we really want to take a walk in Beijing, see the capital and see the great motherland!"

通过admin

Artificial heart made by cutting-edge aerospace technology helps patients with advanced heart failure recover and leave hospital.

  CCTV News:Recently, two patients with advanced heart failure who were installed with the third-generation artificial assisted heart made in China successfully recovered and were discharged from hospital in Tianjin, which also indicates that the research and development technology and performance of artificial assisted heart devices in China have reached the international similar level.

  In order to celebrate the recovery and discharge of two patients, the medical staff specially prepared a warm "Celebration of Freshmen" activity. More than 100 days ago, 39-year-old Mr. Li and 62-year-old Grandma Gao installed the third-generation artificial assisted heart in Tianjin TEDA Cardiovascular Hospital through surgery because of severe heart failure. Now after more than three months of postoperative rehabilitation treatment, both of them can return to normal life.

  Li Jing, a patient undergoing artificial assisted heart implantation: Now I feel no different from normal people. I used to be breathless when I walked, and I couldn’t speak. Now I walk more than 20 thousand steps every day.

  Liu Xiaocheng, medical director of the artificial assisted heart project and dean of Tianjin TEDA International Cardiovascular Hospital: They have two hearts, one is their own heart, the other is a mechanical heart in parallel, and it is enough for them to work, so now they see that their quality of life has completely returned to normal.

  Heart transplantation is the best treatment for patients with advanced heart failure. However, due to the lack of heart donors, the number of heart transplants in China is only a few hundred each year. Implantation of artificial assisted heart is the most effective treatment besides heart transplantation, and its principle is to replace some functions of heart with mechanical pump. The manufacturing precision and technical difficulty of this kind of pump are extremely high. The patient was implanted with an artificial heart developed by China Academy of Launch Vehicle Technology, and its design was integrated with the related development technology of China’s launch vehicle.

  Zeng Guangshang, academician of China Academy of Engineering and expert of China Academy of Launch Vehicle Technology.It is to raise the pressure of human blood and replace a certain part of the function of the heart. Then in the field of aerospace, for example, a liquid rocket engine must pump fuel, and that is to say, the flight control executive system also needs a hydraulic pump, which should be common.

  According to experts, artificial assisted heart technology is relatively mature abroad. In the United States and Europe, about 2,000 patients fight heart failure by installing artificial heart AIDS every year. However, in China, due to its late start, it is still in the early clinical trial stage.

  Miao Qi, expert of the artificial assistant heart project review meeting and director of cardiac surgery department of Peking Union Medical College Hospital.Our country started very late, and it will take a long time to be widely used in this patient with heart failure in the middle and late stage. Seeing the successful experience of these two cases, China’s independent intellectual property rights of artificial heart design, including its application, have great potential.

  The artificial assisted heart to help patients recover successfully was developed by China Academy of Launch Vehicle Technology. So how can rocket technology help patients with heart failure and ensure their survival?

  Xu Jian, chief engineer of artificial assisted heart project and technical director of Aerospace Taixin Company.This is the earliest generation of artificial heart. It is placed outside the body, and four tubes will be connected to the human aorta and pulmonary artery and to the ventricle.

  journalist: How heavy will this be?

  Xu Jian, chief engineer of artificial assisted heart project and technical director of Aerospace Taixin Company.: Basically, the whole set should be about one kilogram.

  CCTV reporter Wang ShiyuThis small cylinder with a diameter of 50 mm and a thickness of about 30 mm in my hand is a device to help the heart of heart failure patients regain power. It weighs only 180 grams, but it can help the heart to provide the energy needed for the blood circulation of the whole body in recent liters.

  It is the design concept of launch vehicle and the development goal of artificial heart to produce greater thrust with smaller self-weight. From the first generation of "giant" artificial hearts that can only be hung outside the body to a new generation of products that can be implanted in the body now, only 180 grams, the application of space technology has helped the rapid development of artificial hearts in miniaturization and light weight.

  Liu Zhigang, Vice President of Tianjin TEDA International Cardiovascular HospitalWe can implant it into the patient conveniently. Even if the patient is a small weight or even a child, it is possible to implant our miniaturized products.

  In addition, the outstanding feature of the third generation artificial heart is that it uses suspension technology to reduce the friction between equipment parts, thus greatly reducing the damage and obstruction to human blood, which is also transformed from aerospace technology. These mature aerospace technologies are transformed into the design and manufacture of artificial hearts, which greatly improves the reliability of artificial hearts.

  Many people will ask, why do people on earth spend huge sums of money and energy to explore the universe when there are still problems like birth, illness, death and illness to be solved? Then the emergence of artificial assisted heart using rocket technology will be a good answer. And space technology is also promoting the progress of human society in this way.

  This workshop, located in China Academy of Launch Vehicle Technology, undertakes the processing and manufacturing of precision pump valves on launch vehicles in China. At the beginning of the construction, researchers never thought that one day, this workshop would also be used to process artificially assisted hearts, bringing hope to patients with heart failure.

  Ding Zhongjun, an expert from China Academy of Launch Vehicle TechnologyFor example, the accuracy of our aerospace parts is one micron. For blood pump parts, the size of its red blood cells is generally ten microns. Therefore, the processing ability and accuracy of this part can guarantee its requirements.

  The titanium alloy used in artificial assisted heart is also an important material on spacecraft. It is the development of aerospace technology that makes the production and precision machining of titanium alloy a mature technology.

  Xu Jian, Chief Engineer of Artificial Assisted Heart Project and Technical Director of Aerospace Taixin CompanyThe biocompatibility of titanium alloy is very good. Most of the artificial hearts in the world are mainly made of titanium alloy, and the processing of titanium alloy is the old line of aerospace, which is an advantage.

  In the development of human space industry, a number of life-changing technologies have been born, ranging from our common instant noodle diapers to nuclear magnetic resonance in the medical field, and even the navigation and positioning technology we use every day. The artificial heart successfully developed by relying on rocket technology has also opened up a new field for space technology to benefit the public.

通过admin

Focusing on Drug Targets: "Fighting poison with poison" —— The latest research progress of oncolytic virus

Since the 19th century, virus therapy for cancer has been studied. However, due to technical barriers and safety problems in genetic engineering, great progress has not been made until the last 20 years. At present, viralvectors for gene therapy and oncolytic viruses (OVs) are the main methods used by viruses as tumor therapy. The main difference between gene therapy virus vector and OVs is that the virus used in gene therapy virus vector is a non-replicating virus, while the vector used in OVs is a virus with replication ability.

93461653176982951

OVs refers to a kind of viruses that can selectively infect and kill tumor cells without damaging normal cells, and they often have good tumor lysis and targeting. OVs can replicate in the host cell after infecting tumor cells, and the released progeny viruses can continue to infect surrounding tumor cells, at the same time activate local or systemic anti-tumor immune effects, change tumor microenvironment and further improve anti-tumor effects. Natural oncolytic virus has some limitations, such as inconsistent safety or weak ability to stimulate the body to produce tumor immunity. In order to overcome the above shortcomings, oncolytic virus vector came into being: it not only retains the ability of oncolytic virus to kill tumor cells, but also enhances its efficacy of activating immune response after genetic modification.

54211653176983336

From non-gene editing type to gene editing type, OVs contains many kinds and characteristics. According to the different nucleotide types of virus genome, OVs vectors can be divided into DNA virus vectors and RNA virus vectors. Among them, the main DNA viruses are herpes simplex virus (HSV), adenovirus (AdV), vaccinia virus (VV) and H1(parvovirus H1. RNA viruses are mainly reovirus (RV), coxsackie virus (CV), poliovirus (PV), measles virus (MV), NDV and vesicular stomatitis virus (VSV).

11771653176983446

The latest research progress

1. At present, five products have been approved for listing in the world, and it is predicted that they will reach the market of over 10 billion dollars in the future.

64651653176983953

2. According to the data of Toubao Research Institute, the market size of oncolytic drugs in China will continue to grow at a compound annual growth rate of 16.2%, and it is expected to rise to 1.43 billion yuan by 2024.

55051653176984020

3. According to the number of research targets, they are IL-12, GM-CSF, PD1, IL-15, PDL1, CD, CD19, CTLA4, NIS, etc.

85001653176984102

4. In the research enterprises, among them, there are many researches and developments on oncolytic viruses, such as Icell Kealex Therapeutics(10), Cell Genesys(7), Virogen Biotechnology (6), PsiOxusTherapeutics(5), Transgene(5) and Jennerex(4). In addition, domestic enterprises such as Innomicro, Synbiotics, Shanghai Medicine, Ruotai Medicine, Kangwanda Medicine, Saibainuo, Lepu Bio, Tasly, and Funuojian are also deployed in this field.

5. Statistics of drugs currently in clinical research stage are as follows:

86651653176984160

two

Introduction of key drugs

Among the five oncolytic viruses approved worldwide, including picornavirus Rigvir, which is approved for the treatment of melanoma in Latvia; Secondly, today’s reborn (recombinant human P53 adenovirus injection) and recombinant human adenovirus type 5, which were approved in 2004 and 2005 respectively, were approved for the treatment of solid tumors such as hepatocellular carcinoma, nasopharyngeal carcinoma and pancreatic cancer. In 2015, the United States and Europe approved the engineered herpes simplex virus (HSV-1) of talimogene laherparepvec(T-VEC) for the treatment of unresectable metastatic melanoma. Finally, in 2021, Japan approved the improved herpes simplex virus teserpaturev for the treatment of brain cancers such as glioblastoma. The statistic of some drugs in that lead stage of clinical development are as follows:

1、CG0070

CG0070 is a genetically modified adenovirus type 5 (Ad5), which contains cancer selective promoter E2F-1 and immune cell stimulating factor GM-CSF gene, and selectively replicates and lyses tumor cells in Rb-deficient tumor cells. The rupture of cancer cells will release tumor-derived antigen and GM-CSF expressed with the virus, thus stimulating systemic anti-tumor immune response. CG0070 was introduced by Lepu Bio from CG Oncology in the United States, and obtained its product development rights and global supply rights in China; Except China, the rights and interests in Japan, South Korea, China, Taiwan Province and other Asian countries were acquired by Kissei Pharmaceutical.

36331653176984638

2、Pelareorep

Pelareorep(AN1004) is a non-pathogenic reovirus introduced by Oncologics Biotechnology by Arnold Pharmaceuticals. It can overcome the neutralizing antibody, selectively infect and destroy tumor cells by activating the body’s own immune system, and is used to treat various solid tumors and hematological malignancies. Pelareorep is a rapidly developed oncolytic virus product that can be administered by intravenous injection in the world. The second phase clinical trial of Pelareorep in the treatment of metastatic breast cancer found that the overall survival rate of patients with ER+PR+/HER2- breast cancer was doubled (21.8 months vs. 10.8 months). In its global phase II clinical trial (BERIL-1) for the treatment of head and neck squamous cell carcinoma (HNSCC), the median survival time of patients was as high as 10.4 months. In March, 2022, Oncologics Biotechnology announced that it had completed the safety assessment of three patients in the metastatic colorectal cancer (mCRC) cohort of the oncolytic virus Pelareorep phase 1/2 GOBLET study.

46101653176984720

3、pexastimogene devacirepvec

Pexastimogen devacirepvec (JX-594) is a genetically engineered vaccinia virus introduced from abroad by Lee’s Pharmaceutical Factory. Its TK gene is mutated, and human GM-CSF gene is inserted to enhance the anti-tumor immune response. The advantages of using vaccinia virus include the stability of intravenous infusion, strong cytotoxicity and the safety of classical live vaccine. Previously, the drug had poor clinical performance in phase III of hepatocellular carcinoma, and the efficacy of the drug in combination with cemiplimab in the treatment of renal cell carcinoma is currently being evaluated.

85231653176985280

4. Naomi Loki

Loki (GL-ONC1, Olvi-Vec) was developed by Genelux Company, and Hengyi Bio owns its development rights in Chinese mainland. It is an oncolytic vaccinia virus. Three expression cassettes encoding β-galactosidase, β-glucuronidase and renin luciferase/green fluorescence (RLuc-GFP) fusion proteins are used to replace virus TK, hemagglutinin and F145L genes respectively. A phase I clinical trial of GL-ONC1 in patients with head and neck cancer showed that intravenous injection of GL-ONC1 combined with standard chemotherapy could improve the overall survival rate. This study also proved the safety of the virus.

34871653176985361

5、OH2

OH2(BS001) is the first candidate drug for oncolytic virus in the world, which is independently developed by Binhui Ib/II-tech, and has chosen HSV2-2 as the carrier and entered clinical trials. Clinical data show that the objective remission rate (ORR), disease control rate (DCR) and one-year survival rate (OS) of BS001 are 30%, 50% and 50%, respectively. In addition, the latest clinical data in the treatment of colorectal cancer show that the objective remission rate of BS001 injection in the treatment of colorectal cancer patients has exceeded 10%. The objective remission rate of BS001 injection combined with PD-1 monoclonal antibody was 18.2%.

57311653176985414

prospect

In recent years, with the development of genetic engineering technology, people have a deeper understanding of the function and structure of virus genes. Optimizing the design and operation of virus genome to produce non-pathogenic viruses has become the research direction of oncolytic viruses, which has greatly promoted the progress of oncolytic virus therapy. Combined treatment of oncolytic virus with chemotherapy or immunotherapy drugs, or even combined application of multiple oncolytic virus drugs, may control tumor progression or cure tumor more effectively, and provide potential clinical treatment options for tumor patients. We believe that with the deepening of oncolytic virus research, oncolytic virus therapy will play a wider and deeper role in treating human diseases.

references

Yang Hao, Zhang Shaogeng, Yang Penghui. Immunological mechanism and clinical research progress of oncolytic virus [J/OL]. Progress in biochemistry and biophysics: 1-16.

[2] Liu P, Wang Y, Wang Y, et al. Effects of oncolytic viruses andviral vectors on immunity in glioblastoma[J]. Gene therapy, 2020: 1-12.

[3] Kaufman H L, Kohlhapp F J, Zloza A. Oncolytic viruses: a newclass of immunotherapy drugs[J]. Nature reviews Drug discovery, 2015, 14(9):642-662.

通过admin

Recalling Bao Beier’s wedding, Jia Ling guarded Ada with his own body, which made me deeply moved!

Description:

Do you still remember the Bao Beier wedding at that time, which was a sensational event? At this romantic and festive moment, we witnessed a remarkable scene: Jia Ling protected Ada with his own body, which was moving and made people deeply admire sincere friendship and brave behavior. Time flies, let’s look back at this touching moment again, which can’t help but make people feel deeply moved.

# # Text:

Once upon a time, the sky was filled with the festive atmosphere of weddings, and everyone was looking forward to witnessing the wonderful moment of Bao Beier and Ada, a happy couple. However, at that moment, Jia Ling’s great friendship made the whole wedding even more unforgettable.

Jia Ling, an ordinary and extraordinary girl, has known Ada for many years and has always been friends with each other. There is no gorgeous performance between them, no hypocrisy, only sincere feelings. Because of this, when Ada was in trouble, Jia Ling stepped forward without hesitation.

At the climax of the wedding, a sudden safety accident threw the whole scene into chaos. As the focus of attention, Ada has become the target of criminals. In the atmosphere of panic, Jia Ling did not hesitate to protect Ada with his body, just like a fearless guardian angel.

The scene at that time was unbelievable! Jia Ling stood up and protected Ada tightly. Her eyes revealed firmness and courage, as if to use her body to block all risks for Ada. This scene of heroic behavior at the wedding deeply touched the heartstrings of every witness.

This friendship is not only a tacit understanding between two people, but also a selfless dedication. Jia Ling’s practice not only shows her deep feelings for Ada, but also best explains her friendship. She didn’t consider her own safety, just to protect her beloved friend. This sincerity and selflessness make people feel admired and moved.

Time flies, we look back on this moment, not only to miss that warm time, but also to commemorate the great friendship shown by Jia Ling. Such friendship, like a bright light, guides us to persevere and move forward bravely in adversity.

It is this spirit that makes us believe that there is still sincere friendship in the world. They are like bright stars, flashing in the dark, bringing us hope and courage. Jia Ling’s behavior proves to us that no matter where we are, friendship can resolve difficulties and smooth the ups and downs. When we face setbacks and dangers, we can believe that there will always be someone like Jia Ling who will stand behind us without hesitation and give us the firmest protection.

Looking back at this touching story of Bao Beier’s wedding, we once again deeply realized the power of friendship. Jia Ling’s act of guarding Ada with her own body not only makes us sigh her courage and great love, but also awakens our deep desire for friendship and care.

Let’s remember this friendship together and understand and pass it on with our heart. Perhaps in our ordinary life, we also need such courage and care to protect those friends who have experienced the storm with us. Because as long as there is sincere friendship, we can face the challenges in the future without fear.

May this touching story live in our memory forever, and may the friendship between Jia Ling and Ada become stronger and stronger. Let’s pay tribute to this sincere friendship and make the world full of more power of truth, goodness and beauty!

The above is the headline tweet I created for you about Jia Ling protecting Ada with her body at Bao Beier wedding. Thank you for reading!

Editor in charge:

通过admin

Chongqing area Xingtu Lanyue is being discounted! The discount 18,000, there is no if you miss it

Welcome to Autohome Chongqing Promotion Channel, bringing you real-time car market dynamics. Now, the high-profile models are having an exciting promotion in Chongqing area. It is understood that consumers who buy Xingtu Lanyue can enjoy a cash discount of up to 18,000 yuan, and the minimum starting price has been reduced to 175,900 yuan. This opportunity is not to be missed. If you are interested in Xingtu Lanyue, be sure to click "Chatti Car Price" in the quotation form to lock in the current most competitive price and strive for higher discounts. Hurry up and don’t miss this car buying opportunity!

重庆地区星途揽月正在优惠!优惠1.8万,错过就没有

The exterior design of Xingtu Lanyue shows a strong sense of modernity and power. Its front face adopts a unique family-style design, and the air intake grille is large and three-dimensional, like a galaxy, showing the fusion of luxury and technology. The body lines are smooth, the overall style is tough and atmospheric, and the angular outline highlights the extraordinary sporty temperament, whether it is static or dynamic, it is very visual impact. The exquisite craftsmanship in the details further enhances the sense of quality of Lanyue, making it stand out among many SUVs.

The side lines of Xingtu Luoyue are smooth and dynamic, and the body size is 4970mm*1940mm*1792mm, showing a stable and atmospheric attitude. The wheelbase is 2900mm, making the interior space more spacious and comfortable. The front and rear wheel tracks are equal, 1644mm, ensuring driving stability. The tire size is 245/50 R20, and the delicate wheel design not only enhances the visual effect of the vehicle, but also ensures the superiority of driving performance.

重庆地区星途揽月正在优惠!优惠1.8万,错过就没有

The interior design of Xingtu Lanyue is full of luxury and technology. The spacious interior space is made of exquisite leather materials, providing passengers with excellent touch and comfort. The steering wheel is wrapped in leather, and it is equipped with manual up and down and front and rear adjustment functions to ensure the driver’s convenience of control. The focus of the center console is the 15.6-inch large-size touch screen, equipped with advanced automatic speech recognition control system, which can easily control multimedia, navigation, phone and vehicle functions. In addition, there are rich USB and Type-C interfaces in the car, including 2 in the front row and 3 in the back row, to meet the charging needs of passengers’ electronic devices. The main and passenger seats are equipped with heating and ventilation functions, and the driver’s seat also has an additional power seat memory, while the second row of seats supports front and rear and backrest adjustment, and has a proportional reclining function to fully meet the needs of different passengers. The interior design of Xingtu Lanyue is both practical and attention to detail, aiming to create a high-end comfortable driving experience.

重庆地区星途揽月正在优惠!优惠1.8万,错过就没有

Xingtu Lanyue is equipped with a powerful 2.0T turbocharged engine, which releases 261 horsepower and reaches a maximum torque of 400 Nm, ensuring strong performance in the car. With the 8-speed automatic transmission, the driver can enjoy a smooth gear shifting experience and efficient power transmission. This is an engine configuration that focuses on power output and driving pleasure.

Summarizing the evaluation of Autohome owners, Xingtu Lanyue has won praise for its atmospheric appearance and domineering temperament. The owner particularly emphasized the refinement of the interior and the performance of the engine, and the embellishment of the ambient light has enhanced the overall sense of technology. Compared with the joint venture car at the same price, Xingtu Lanyue shows higher cost performance. The owner believes that this is not only the pursuit of quality, but also the support of domestic brands. Xingtu Lanyue has undoubtedly left a deep impression on the owner in terms of appearance design and intrinsic value, and has become a favorite choice for the family.

通过admin

Deng Chao comforted Baober to quit "Running Man": I believe we will meet again

Deng Chao Weibo

Bao Bell Weibo


??1905 movie network news Recently, Bao Bell admitted to quitting. He posted on Weibo saying "Goodbye, Running Man!", indicating that he withdrew due to scheduling issues. The new member of the Running Man Group to replace Bao Bell is Lu Han.

??In the Weibo video, Bao Bell had tears in his eyes and choked up several times, explaining that he could not participate in the third season of Running Man due to schedule reasons. He also thanked the program staff and Deng Chao, Li Chen, Chen He, Wang Zulan, Angelababy, and Zheng Kai one by one in the video.

    "Hello everyone, I’m Bao Bell, the bag of the schoolbag, the precious Bei, from Harbin, can you recognize me? I may not participate in the next season of Running Man because of the schedule. I would like to thank Zhejiang Satellite TV and the staff of" Running Brothers "for taking care of me and choosing me who is not so good. The second thank you is to the audience who like me. You have given me a lot of encouragement and support, which has given me the confidence to record these 12 episodes of Running Man and let me play like a child. Finally, thank you" Six ", we are family."

    "Thank you Chao, when I feel the hardest, you help me tell me how to be a good person. Thank you baby, when someone attacks me, you are the first to stand up for me. Thank you Li Chen, you let me know what strength is and what perseverance is. Thank you Chen He, every time I have something to do, you are the first to come out and stand by my side. Thank you Zu Lan, your heart is like an angel. You will make everyone happy. Thank you Zheng Kai, although we are all from" To Youth ", I am a little jealous every time I see you, because you are so excellent, so handsome, so happy, so good." In the end, Baobert choked up: "So people who hate me won’t see me on Running Man, and people who like me will see me in more film and television works."

??In this regard, Deng Chao, a member of "Running Man", took the lead in posting a message on Weibo to comfort "Xiao Bao, don’t cry, I will feel distressed to see you cry", and also said that we will meet again in the future. Deng Chao is rarely serious, and his words are sincere and affectionate. Users have praised: "You two are real brothers" and "It seems that you have said the most emotional words".


Deng Chao Weibo Original:

??Xiao Bao, don’t cry, I will feel distressed to see you cry. At this time, you remind me of the time when you painted the wall, you and I fought side by side for dozens of days and still parted ways. Life may be like this. Since fate soon arranged for us to meet in Running Man, we have reason to believe that we will meet again soon. When you are outside logging, there must be times when you are tired, don’t forget to go back to logging.