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Mom sees the kua series! What to give on Mother’s Day will not be said to be wasteful.

　　Has the May Day holiday syndrome slowed down? Ladies and gentlemen, Mother’s Day will come quietly this weekend. Compared with previous years, this year’s atmosphere is quite special. Perhaps everyone has recently experienced a long period of contact or separation with their families, and everyone should maintain a sense of ceremony for the festival!

　　Although the time is short, don’t rush to place an order to buy a gift. It’s better to see what kind of gift will make mothers feel disgusted and think you are wasting money. If you step on these minefields, it may not be too late to save them.

　　I believe many people will take this opportunity to send gifts to their mothers who have worked hard to raise themselves to show their filial piety and gratitude. Women love flowers, and the best choice is often to choose a bunch of flowers with profound meaning, but carnations and the like seem to be nothing new every year. Black roses are advanced and beautiful, and flowers are gentle and sincere, which seems to be a good choice. But my mother feels happy when she receives flowers, but at the same time she feels that it is not real enough. Wouldn’t it be perfect if the gift is both beautiful, practical and meaningful?

　　Keep mom elegant and beautiful with beauty cosmetics.

GISELE BU?NDCHEN celebrated Mother's Day together.

　　At the moment of the epidemic, mothers originally liked to receive some lipsticks as gifts, but because the frequency of wearing masks is too high now, the probability of mothers wearing lipsticks is greatly reduced, and the utilization rate is not very high. Therefore, anti-aging and whitening skin care products are very important. After all, for middle-aged mothers, maintaining good skin is more important than making delicate makeup.

　　When it comes to skin care products, in the final analysis, it is still necessary to choose products according to the skin quality of mothers. As mature female mothers, the main demands for skin care are still to lift and tighten, lighten spots and remove yellow, resist aging and wrinkle. According to these complaints, the editor has sorted out some popular whitening and anti-aging products. Come and choose gifts!

　　First, lifting and firming-product recommendation for anti-aging products

　　1, fresh Fu Lei Shi Gu Yuan White Diamond Truffle Mask 3500 yuan /100ml

　　The precious "white truffle active essence" will be completely preserved in fresh Fu Lei Poetry, and the ancient white diamond truffle mask 2 will be carefully created. This extraction technology skillfully uses the enzyme as a catalyst to extract the active molecules of white truffles with specific enzymes, thus releasing the effect of active extraction of white truffles. This ingredient can effectively fade expression lines and improve skin toughness and elasticity. Therefore, Guyuan White Diamond Truffle Mask 2 can instantly and intensively nourish smooth skin for 4 or 1 night +18%6, smooth expression lines such as head lifting lines, decree lines and brow lines around 7, at the same time, skin elasticity +23%7, and skin brightness +27%7.

　　2. Sea Blue Mystery Concentrated Repair Essence 15ml/1720 yuan.

　　The concentrated essence of Sea Blue Mystery can deeply repair, quickly strengthen and resist oxidation, accelerate the self-healing and regeneration of cells, build a matrix network of healthy cells at the bottom, quickly strengthen the skin barrier, instantly relieve the redness and sensitivity of the skin surface, and make the skin strong and regenerate from the inside out. The new aquamarine mystery concentrated repair essence instantly relieves sensitive redness; Continuity-repair the strong barrier; Prospective-Anti-skin oxidation

　　3. Yuebi Shidai Mengning Energy Cream 50ml/2965 yuan.

　　For the skin that needs immediate special repair, Daimeng Repair Special Cream provides full-effect anti-aging and beauty-beautifying function, and at the same time gives the skin the best ability to self-adjust the protective layer. Pure ursolic acid extracted from "rosemary leaves" can repair damaged skin and enhance skin’s natural ability to resist elastin fiber decomposition. Use it every morning and evening. Evenly apply proper amount to the whole body and neck, and gently massage until completely absorbed. The best skin care effect will be obtained by combining it with Diamond Drops Dream Nourishing and Protecting Gel, and sealing the active ingredients directly to the bottom.

　　4, IPSA INFOSHA high-energy black crystal cream 1280 yuan /30g

　　The brand-new upgraded high-energy Black Crystal Cream (full name: Black Crystal Rui Misu Facial Cream) brings a brand-new anti-aging idea to the majority of women. A new generation of high-energy black crystal cream combines the cutting-edge technology and precious ingredients of IPSA Japan Research Center, focusing on revitalizing the strength of facial muscles, and making the whole face firm and uplifting by enhancing facial traction and support; At the same time, it contains multiple essences to cooperate with anti-aging and improve the traces of aging in all directions.

　　5. Key Crystal Revitalizing Essence of CPB Skin Nickname: Diamond Essence ‘1980/50mL

　　The diamond-polishing essence used in the first step after cleansing has three unique essences, and is rich in the brand soul ingredient’ Brightening Muscle and Revitalizing Essence’, which can go deep into the root of skin and start the qualitative change of skin; Adding the essence of five-fold thinning can effectively accelerate skin microcirculation, delay oxidation, deeply activate cell collagen, strengthen and stabilize skin; Activate epidermal cell regeneration; It also incorporates the exclusive’ Instant Penetration Muscle Bottom Technology’, so that multiple thinning and essence ingredients can quickly penetrate into the muscle bottom, awakening skin innovation and qualitative change. Improve the skin quality from the source, make the skin full, bright and tender, shine and beautify the skin, and praise the new beauty of the skin.

　　6, Snow Show Yu Shi Tight Yan Shen Yang Essence Dew (super plastic time bottle) 50ml/1360 yuan

　　Snow Show’ Superplastic’ Time Bottle contains ginseng peptide and legendary essence of GINSENOMICS?, which concentrates 100,000 rounds of superplastic energy, and adopts the tip suspension microcapsule sealing technology to achieve 7-day superplastic lifting and tightening of skin. Start collagen regeneration within 48 hours after touching the skin, moisten and relieve, improve irritation and make the skin firm layer by layer. A bottle of concentrated 100,000 rounds of legendary vitality and super-plastic energy can improve skin aging in many dimensions. After 8 weeks of use, the skin density was +35.907% filling +24.242% lines -19.962%.

　　7, the new Yuxi gold eye cream 480 yuan /20ML.

　　Gold-plated eye cream is also compounded with many ingredients, which can effectively fight the problem of dark circles. Aescin can effectively promote eye circulation, add caffeine, effectively dilute dark circles, solve the problem of dull eyes from the source, and make the skin around the eyes clear and bright, leaving a moist, soft and bright look on the bottom of the skin. The essence of rare CORDYSINESIS? high-functional Cordyceps sinensis can effectively reduce the production of protease MMP, thus inhibiting the decomposition and loss of collagen, staying in the muscle bottom collagen and stabilizing the supporting structure.

　　8. BIOEFFECT Aurora Limited Edition Essence 4888 Yuan /50ml

　　BIOEFFECT Aurora Limited Edition Essence Dew, a little bit can not only create a miracle of skin care. Only 2-4 drops per night can obviously and permanently improve the skin condition. This time, the unique black barley is still used to extract the main active ingredients. Compared with the regular version, the capacity is increased to 3 times and the concentration of active ingredients is increased to 2 times, bringing a truly effective skin care experience.

　　9. French Guerlain Emperor Bee Face Cream 50ml/RMB1490

　　Guerlain Restoring Cream can not only strengthen the skin barrier, maintain the skin balance, enhance the skin’s natural defense ability, protect it from environmental oxidation factors, bring you smoother, firmer and more balanced skin, and create a natural matte luster. Guerlain Restoring Cream adopts a brand-new formula that is more environmentally friendly, and combines the classic antioxidant vitamin E, which has a powerful repairing effect.

　　Every mother was once a girl, who was weak, confused, self-centered and emotional. After years, they are still elegant and beautiful women.

　　Second, light spots to remove yellow, brighten skin color products recommended

　　After the skin care step, you can use a facial beauty instrument for facial health care to tighten the skin, optimize the facial contour, relieve tension and relieve facial muscles. You can also use a cold care ring and a hot care ring to help the skin absorb cream, reduce facial edema and improve facial luster.

　　TheraFace? PRO multifunctional hand-held facial health care instrument. This device combines the three concepts of health, technology and beauty, and takes facial health equipment to a new height.

THERAFACE-PRO- Multifunctional Hand-held Facial Health Care Instrument -LED Red Light
THERAFACE-PRO-COLD

　　TheraFace PRO can effectively relieve facial tension, relax facial muscles, realize deep care, and relieve the discomfort caused by migraine, headache and jaw pain. This facial health solution will change the lives of millions of people and make professional facial physiotherapy at your fingertips. The product offers six unique modes,

　　We can improve facial contour, increase skin firmness and improve skin health through impulse therapy, LED light therapy, cleaning and micro-current therapy.

　　Third, add elegance and agility, and recommend temperament and fragrance

　　Affected by the epidemic, masks have become a necessity for everyone to go out. Yes, the mask covers the make-up. If you want to directly highlight your personality, you can use perfume to express it. In order to highlight the temperament of mothers and add elegance and agility, come and see these perfumes!

　　Enhance mom’s temperament with exquisite accessories.

　　Nowadays, middle-aged and elderly people are gradually becoming active users of WeChat. Middle-aged and elderly people send WeChat messages 44 times a day. At the same time, don’t think that mothers only like to forward some chicken soup for the soul and take beautiful photos of themselves and their friends, which is also a pleasant thing. But how can we make our mother a master of praise in PYQ? These exquisite accessories to enhance temperament must be essential!

　　1, tiffany Tiffany chain necklace [China limited edition ]Tiffany HardWear series.

　　Tiffany HardWear series design praises the fearless spirit and avant-garde energy of the city. This limited-edition work is designed with this series of iconic links, with carefully polished 18K gold and bright ruby, which is refreshing. Can be worn alone, or stacked to create a stunning shape.

　　2、PANDORAWishing bone ring

　　PANDORA smooth wishing bone ring (left)

　　PANDORA’s bright wishing bone ring (right)

　　PANDORA ring is easier to start with than expected, and it is a perfect gift for mom! The 14k gold-plated material is not worried about oxidation and fading when worn, and it looks good when worn alone or mixed.

　　3. Hermès Hermes Scarf

　　Twill silk "Hermès Story" 90cm square towel

Hermes-Story-scarf-90-cm-in-silk-twill

　　The pattern of this square towel was designed by Jonathan Burton, showing a playful wink at social media. In the design, a circus performer stands on a fine horse at the top of a snowy mountain, holding a selfie stick, and her animal companions enter the camera in various difficult postures to jointly maintain their own balance. Behind the mobile phone is a small red heart that keeps flying.

　　Twill silk "Isola di Primavera" 90cm square towel

Isola-di-primavera-scarf-90-cm-in-silk-twill

　　The designer of this square towel is Matthieu Cossé, who once created a huge mural for Hermè s’ main store in Fubao Avenue, Paris. In this square towel, Matthieu Cossé presents a poetic "spring island": slow waves, warm spring breeze, and flowers and trees that flourish in the sun. With modern design and improvisational watercolor brushwork, the painting represents romantic Italian style full of fantasy.

　　4. Daniel Wellington QUADRO CORAL Watch

　　QUADRO STUDIO watch

　　DW watches have launched a variety of new contours in recent seasons. Quadro Studio with square design uses exquisite and compact square dial to inject fashionable new ideas into classic watches. The whole series is made of polished stainless steel, which is durable and durable, and provides exquisite rose gold plating to meet the mood of wearing it every day.

　　5, Chanel box sunglasses

　　Sunglasses are really a good choice for mom’s gift, which can not only resist the damage caused by strong sunlight to eyes, but also exude a sense of elegance and extravagance at any time. Chanel’s new box sunglasses are made of metal and calf leather, and wearing these sunglasses to take pictures of mom is simply the most shining star!

　　6. Midsummer Moon Jewelry Twinkle Moon

　　stars

　　The timeless combination of the stars and the moon gives people a mysterious and beautiful feeling and brings infinite fantasy. Design inspiration comes from the universe, in which we are just a blue dot, and human beings are so small that nature needs our praise. The design and modeling combine diamonds with the stars and the moon representing the operation of the universe from the planet, forming a harmonious picture of nature. Designers give jewelry a powerful force with a unique perspective. Yellow diamonds are like the existence of the sun. When the wonderful energy of the sun, moon and stars is combined, the mysterious power of the universe will soon be opened.

　　waltz

　　The quiet summer waltz, with the dancing music, dances gently in Erpang. The breeze blew gently, bringing fragrance of flowers. This design was inspired by the beautiful party scene in the summer garden. The design of bow ribbon makes the ears full of tenderness and grace. Designers use sapphire inlay to outline the sense of lines, which makes the ribbon unique, gentle and design sense coexist.

　　Emancipating Mom’s Hands with Smart Home Appliances

　　Compared with digital household appliances such as cameras and computers, mothers may prefer household appliances that can bring convenience to their lives. After all, liberating your hands is your favorite ultimate goal, isn’t it? In recent years, there are many new products that can reduce housework, and some convenient small kitchen appliances can also increase the mood of life and improve the efficiency of cooking.

　　1, dishwasher

　　It’s hard enough for mothers to cook for their families every day, and they have to clean the dishes after meals. If you don’t want to wash the dishes either, then an excellent dishwasher may solve this problem, which not only protects your hands but also saves time. The function of cleaning and disinfection is also to contribute to the health of your family.

　　2, juicer, cooking machine

　　When parents are old, they should pay more attention to health. A juicer and a cooking machine can help them enjoy their old age, improve the efficiency of cooking and make their lives healthier and greener.

　　3. Sweeping robot

　　Family cleaning can be said to be one of the most important tasks for mothers at ordinary times. A sweeping robot that can truly free hands and sweep and drag is almost one of the essential small household appliances in the home. Let the sweeping robot become a necessary item in your home on Mother’s Day.

　　4. Eye massager

　　Every night, your mother is still working overtime or preparing things for you tomorrow. In order to keep up with the society, the frequent use of various electronic product apps will also increase the duration of eye use. With the growth of age, mothers’ eyesight will gradually decline.

　　The eye massager uses infrared rays to heat the eyes, which can adjust the metabolism of the eyes and improve the nutrition of the eyes nerves, which is good for restoring vision. The eye massager can also effectively relieve eye fatigue, improve eye dryness and other symptoms, and also play a role in reducing dark circles. I believe my mother will like this gift on Mother’s Day.

　　5. Air fryer

　　Air fryer is a popular kitchen appliance in recent years. It can make delicious dishes with little right or no oil, and it can also be used to make dried fruits. The speculation is also very simple, and anyone can make rich dishes.

　　Make a gift with your hand to please your mother.

　　It is better to buy a bunch of flowers than to make a bunch of flowers by hand. A bunch of handmade flowers can show my mother’s weight in my heart and give her full love.

Image source: pinterest website

　　In the end, companionship is actually the longest-lasting confession. It is better to accompany your mother than to send Jinshan Yinshan. The best gift for your mother is that you take time to spend more time with your family. The days when you can accompany your parents are getting smaller and smaller every year. Take the opportunity of the festival to talk to your mother and cook her a meal, or take her out for camping and outing, chat with her more and share your daily life with her!

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How to diagnose and treat ANCA-related vasculitis？ This article is too comprehensive.

Original Socrates’ afternoon tea medical rheumatism immunity channel

* For medical professionals only.

AAV is a systemic necrotizing vasculitis involving multiple organs and systems.

Recently, a summary of clinical practice on the diagnosis and treatment of ANCA-associated vasculitis (AAV) was published in Rheumatology. Let’s take a look at what dry goods are available ~

Figure 1: Screenshot of this overview.

Performance of AAV

AAV is a group of systemic vasculitis characterized by the detection of ANCA in serum, which mainly involves small blood vessels. It is characterized by full-thickness inflammation, necrosis and granuloma formation in small blood vessels.

Common symptoms can be manifested as fever, joint pain, myalgia, fatigue, weight loss, etc. When lung, kidney, gastrointestinal tract, nervous system and five senses are involved, corresponding clinical manifestations will appear. Musculoskeletal symptoms of the whole body are not specific, but they are common; The following clinical manifestations can also occur alone or in combination: chronic recurrent sinusitis accompanied by nasal scab, hollow pulmonary nodules, rapidly progressive necrotizing oligoimmune complex glomerulonephritis, multiple mononeuropathy, pericarditis or myocarditis and obvious purpura, while respiratory and renal failure at the same time is called "pneumorenal syndrome", which is an acute and severe manifestation of AAV.

Generally speaking, multiple organs and systems involved at the same time and obvious inflammatory reaction are often the key clues to diagnose AAV.

How to diagnose?

1, patient evaluation and diagnostic evaluation

When the diagnosis of AAV is suspected, a comprehensive clinical evaluation should be conducted to assess whether all the organs that may be involved are involved (see Table 1).

Table 1: Patient Assessment and Diagnostic Assessment

Routine blood tests should be carried out, and alveolar hemorrhage should be highly suspected if there is a continuous decrease in hemoglobin level.

Urine analysis is essential in finding hematuria, proteinuria and urine culture to eliminate infection, and the detection of proteinuria needs to be evaluated by quantitative urine protein/creatinine ratio.

All patients underwent chest X-ray examination. When respiratory involvement (such as alveolitis, pulmonary infiltration or nodules) is suspected, chest CT examination should be conducted in time.

When ENT involvement is suspected, CT examination of paranasal sinuses must be performed and evaluated by ENT experts (including nasal and laryngeal fibroscopy, etc.).

Electromyography was performed when peripheral nerve involvement was suspected.

In a word, it is suggested to carry out multidisciplinary examination according to the organ system involved.

2. The value of ANCA screening

It is strongly recommended to screen ANCA, and the detection of protease 3(PR3)-ANCA and myeloperoxidase (MPO)-ANCA is highly specific.

In the meta-analysis of evaluating the value of ANCA, the sensitivity and specificity of anti-PR3 antibody were 80% and 93%, while the sensitivity and specificity of anti-MPO antibody were 58% and 96%. The specificity of ANCA was different between granulomatous vasculitis (GPA) and microscopic polyangiitis (MPA), with PR3-ANCA positive accounting for 78%-87% in GPA and MPO-ANCA in MPA.

ANCA was not detected in the blood of about 10% patients with GPA and MPA, reminding us that there may be other biomarkers that have not been found when considering the diagnosis of AAV.

Besides AAV, ANCA is occasionally found in some patients with infection, other autoimmune diseases and other vasculitis.

3. When will the biopsy be performed?

Biopsy of kidney, lung, nose, nerve and muscle tissue can provide reliable evidence for the diagnosis and differential diagnosis of diseases.

The diagnostic rate of pathology may vary significantly with different biopsy sites. For example, renal biopsy has a high diagnostic rate, while paranasal sinus biopsy often suggests nonspecific inflammation.

Although biopsy is the gold standard and strongly recommended, in clinical practice, when the clinical manifestations are consistent with ANCA detection, biopsy can be omitted. In the latest classification standards of American Rheumatology Association (ACR) and European Union Against Rheumatism (EULAR) in 2022, when other diseases simulating vasculitis are excluded and diagnosed as vasculitis, biopsy is not a mandatory standard.

In short, biopsy (especially renal biopsy) should always be considered for patients suspected of active disease to evaluate the condition.

4. Classification criteria of MPA and GPA

At present, there is no diagnostic standard for AAV, so clinical manifestations, histological and laboratory data are very important for diagnosis.

Figure 2: GPA classification standard updated by 2022 ACR/EULAR

Figure 3: MPA classification standard updated by 2022 ACR/EULAR

The total score ≥5 points can diagnose GPA or MPA.

Treatment

1. Glucocorticoid

When the diagnosis of AAV is suspected, GC should be started, and the initial measurement is 1mg/kg prednisone (or equivalent) per day, or 500-1000mg methylprednisolone intravenously for 3-5 days.

PEXIVAS research shows that for critically ill patients who initially received methylprednisolone shock therapy, the GC dosage is reduced faster than that of the traditional regimen, that is, prednisone is reduced to 20mg per day within 7 weeks after starting treatment and 5mg per day within 19 weeks, which is as safe and effective as the standard dosage. The research shows that the risk of serious infection is low within one year.

LOVAS study showed that the initial remission of AAV (inanimate/severe organ involvement) was induced by GC of 0.5mg/kg/ day. As RITAZAREM study showed, the incidence of hypogammaglobulinemia (IgG<5g/L) was halved during the follow-up period.

It is mentioned that GC should be gradually reduced after induction of remission, and may be stopped gradually within the first year after diagnosis. At present, there is no high-quality evidence to support the need to maintain the optimal dose and duration of GC for AAV remission, so GC treatment should be individualized.

2. Immunosuppressive drugs that induce remission

① severe AAV

GC combined with cyclophosphamide (CTX) or rituximab is the standard scheme to induce severe disease remission at present, although more and more evidence shows that in some subgroups of patients, such as PR3-ANCA positive patients and patients with disease recurrence, rituximab is better than CTX to maintain fertility.

CTX can be administered intravenously or orally, and the dosage should be reduced in elderly patients with renal insufficiency. The dosage of 15mg/kg is selected according to the most widely used CYCLOPS regimen in Europe. Compared with the daily oral regimen (2mg/kg/d), the cumulative dosage of CTX can be reduced by 50%, and the remission rate is similar, while the end-stage renal disease, adverse events or survival time have not increased, but the risk of disease recurrence has increased in the long run.

The two regimens usually stop taking drugs 3-6 months after remission, and then start maintenance treatment.

Rituximab (375mg/m2 per week, four times in total or 1000mg twice every two weeks) is not inferior to CTX in inducing remission, and it is more advantageous in PR3-ANCA positive or recurrent patients.

There is little evidence to compare CTX with rituximab in patients with low glomerular filtration rate (< 20 ml/min/1.73m2). According to the suggestion of KDIGO guidelines in 2021, in addition to the first and third intravenous use of 15mg/kg CTX, such patients can also choose to use 375mg/m2 of rituximab combined with CTX for four consecutive weeks. However, this combination may bring additional risk of infection, and a recent retrospective study showed that rituximab alone may be as effective as CTX in inducing remission in patients with eGFR<30ml/min/1.73m2.

In all patients, compound sulfamethoxazole should be taken orally for at least 3 months after the last use of CTX to prevent pneumocystis carinii pneumonia (atrovaquinone or pentamidine aerosol should be used in case of intolerance/allergy) until B cells are rebuilt after rituximab treatment.

② Non-severe AAV

For non-serious disease-induced remission, rituximab is more effective than conventional immunosuppressants, and MTX and MMF can be used as substitutes when rituximab or CTX cannot be used. Studies have shown that MTX and MMF are not inferior to CTX in the remission rate of 6 months, but the recurrence rate during follow-up is higher than CTX, especially in PR3-ANCA positive patients.

3. Immunosuppressive drugs to maintain remission

After CTX or rituximab combined with low-dose GC induction therapy, rituximab (500 mg every 6 months) is superior to azathioprine in the maintenance and remission of GPA and MPA. It has been proved that the maintenance treatment of rituximab (1000mg once every 4 months) is safe and effective in patients with recurrence. For patients with contraindications to rituximab, AZA or MTX can be considered as alternative therapy.

On the other hand, the use of rituximab may lead to hypogammaglobulinemia and increased risk of infection, so it is suggested to use low-dose rituximab to maintain remission. In clinical practice, not only drug safety but also the risk of disease recurrence should be considered.

AZA(2mg/kg/ day) and MTX(0.3mg/kg increased to the maximum of 25mg/ week) have similar effects on maintaining remission of AAV, and they are second-line drugs for maintaining remission. Patients with impaired renal function (eGFR<45ml/min) should avoid using MTX.

At present, EULAR recommends maintaining treatment for at least 2 years, and recent studies using rituximab or AZA regimen show that immunosuppressive treatment for more than 2 years can reduce the recurrence rate of the disease.

4, plasma exchange and complement C5 receptor inhibitors

PEXIVAS research shows that routine plasma exchange treatment for severe GPA/MPA patients with glomerulonephritis (eGFR<50ml/min/1.73m2) or alveolar hemorrhage has no benefit. This result is contrary to the previous MEPEX1 study, which may be due to the stricter inclusion criteria of the latter [creatinine (> 5.8mg/dl) and glomerulonephritis confirmed by biopsy are required]. The subgroup analysis of PEXIVAS study showed that plasma exchange did not benefit significantly in these subgroups.

Meta-analysis published recently shows that plasma exchange at the age of 12 months in patients with severe renal disease may be beneficial to the prognosis of kidney if the infection rate is high.

Therefore, even with severe renal disease, the use of plasma exchange is still controversial, and it is not recommended as a routine treatment.

It is worth noting that the position of international guidelines on plasma exchange of AAV is quite different. The KDIGO Alliance recommends plasma exchange for patients who need dialysis or whose creatinine increases rapidly > 500 mol/L (> 5.8 mg/DL), or for patients with severe hypoxemia and alveolar hemorrhage, while the 2021 ACR guidelines suggest that plasma exchange is not recommended for patients with active AAV glomerulonephritis or alveolar hemorrhage. EULAR 2022 suggested that plasma exchange should be considered in patients with rapid increase of creatinine > 300μmol/l, but there is no evidence that routine plasma exchange can treat alveolar hemorrhage.

Recently, in addition to CTX or rituximab, avacopan, an oral complement factor C5 receptor inhibitor, has been approved and licensed for the induced remission and maintenance treatment of severe AAV, in order to replace or limit the dosage of GC.

So which patients will benefit the most from this new treatment, especially considering the cost of the drug, is still worth discussing.

According to the study of its mechanism of action, avacopan seems to be the most useful for patients with severe kidney disease and alveolar hemorrhage, as well as patients with high risk of GC-induced comorbidity, including the elderly.

summary

When the patient is highly suspected of AAV, further ANCA detection is needed, and all organs are evaluated, and if necessary, tissue biopsy is performed to make a definite diagnosis.

Clinical treatment strategies should vary according to the severity, age, weight, complications and prognosis of AAV.

Recent studies support rituximab as the first choice to induce and maintain remission.

In addition, compared with the conventional scheme, a small amount of GC is equally effective and safer in inducing remission.

There is insufficient evidence to support the routine use of plasma exchange for treatment.

References:

Baptiste Chevet, Divi Cornec, Marta Casal Moura, Emilie Cornec-Le Gall, Diagnosing and treating ANCA-associated vasculitis: an updated review for clinical practice.[J] Rheumatology.

This article is the first channel of rheumatism immunity in medical field.

The author of this article is Socrates’ afternoon tea.

This article reviews Chen Xinpeng, Deputy Chief Physician.

Responsible editor, cassette tape

Copyright statement

This article is original. If you need to reprint it, please contact authorization.

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The Central Meteorological Observatory continued to issue a typhoon red warning at 18： 00 on September 1.

　　CCTV News:The Central Meteorological Observatory continued to issue a typhoon red warning at 18: 00 on September 1:

　　The center of Typhoon Sura No.9 this year (super typhoon level) is located at 5 o’clock in the afternoon today (September 1) in the northeastern South China Sea, about 110 kilometers south-east of Hong Kong, that is, 22.0 degrees north latitude and 115.1 degrees east longitude. The maximum wind force near the center is 17 (58 meters per second), the lowest pressure in the center is 925 hectopascals, and the radius of the seven-level wind circle is 250-280 kilometers.

　　It is estimated that "Sura" will move from north to west at a speed of 10-15 kilometers per hour, and its intensity will slowly weaken. It will land or brush the coast from Taishan to Shenzhen in Guangdong in the early morning of September 2 (strong typhoon level, 42-50 m/s, 14-15), and then move to the south-west direction.

　　In addition, the center of the 11th typhoon "HAIKUI" this year is located at 5 o’clock in the afternoon today (September 1st) in the northwest Pacific Ocean about 770 kilometers south-east of Taipei City, Taiwan Province Province, which is 22.4 degrees north latitude and 128.5 degrees east longitude. The maximum wind force near the center is 12 (33m/s), and the lowest pressure in the center is 975 hectopascals, with a seven-level wind circle.

　　It is estimated that "Anemone" will move westward at a speed of 15-20km/h, and its intensity will gradually increase, with the strongest typhoon level (42-45m/s, level 14). It will land on the eastern coast of Taiwan Province Island around the evening of the 3rd, then pass through Taiwan Province Island and gradually approach the coast of Fujian.

　　Gale forecast:From 20: 00 on September 1 to 20: 00 on September 2, affected by Sura, the Taiwan Province Strait, the central and southern South China Sea, the waters near Nansha Islands, zhongsha islands and Huangyan Island, and the coastal areas of Zhejiang will have 6-7 grades and gusts of 8-9 winds; There will be strong winds of 7-9 grades and gusts of 10-11 grades in the northwest of the South China Sea, Fujian coastal areas, Guangdong coastal areas, the Pearl River Estuary, Hong Kong and Macao, etc., and there will be strong winds of 10-12 grades in some of the above sea areas or areas, and the winds in the nearby seas or areas passing by the "Sura" center will be 13-17 grades and gusts of 17 or above; Affected by Anemone, there are 6-7 grades in the south and east of the East China Sea and east of Taiwan Province, 8-10 grades in some sea areas, and 11-12 winds in gusts.

　　Precipitation forecast: From 20: 00 on September 1 to 20: 00 on September 2, due to the influence of Sura, there were heavy rains in southeastern Fujian, central and southern Guangdong, Hong Kong and Macao, among which there were heavy rains in parts of southern Guangdong, Hong Kong and Macao, and local heavy rains (250-280 mm).

　　Defense guide:

　　1. The government and relevant departments shall, in accordance with their duties, do a good job in typhoon prevention and emergency rescue.

　　2. Water operations and passing ships in relevant waters should return to Hong Kong to take shelter from the wind, strengthen port facilities, and prevent ships from anchoring, grounding and collision.

　　3. Stop large-scale indoor and outdoor gatherings and dangerous outdoor operations such as high altitude.

　　4. Reinforce or dismantle structures that are easy to be blown by the wind. Personnel should not go out at will. They should stay in windproof and safe places as far as possible, so as to ensure that the elderly and children stay in the safest place at home, and the dangerous people will be transferred in time. When the typhoon center passes by, the wind will decrease or stay still for a period of time. Remember that the strong wind will suddenly blow and you should continue to stay in a safe place to avoid the wind.

　　5. Relevant areas should pay attention to prevent flash floods and geological disasters that may be caused by heavy precipitation.

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Starting with Yan value, falling into talent and comprehensively testing Geely Xingrui.

　　[car home Professional Evaluation] In the early publicity of Geely (|), we saw that Geely officials used the word "super matrix", which probably showed that they had enough confidence in this car based on CMA modular platform. In addition, there are four "new standards" on slogan, namely: intelligence, health, motivation and space. Coincidentally, these standards all have corresponding relations (intelligence, safety, dynamics and comfort) in our AH-100 4.0 evaluation system. Before it’s too late, let’s verify its comprehensive product strength when the test car is available.

Home of the car

Home of the car

　　The test vehicle this time is the most equipped flagship type in the whole department, with a guide price of 149,700 yuan. At present, in addition to this one, there are two downstream configurations (the elite type does not accept reservations for the time being), so according to the luxury type calculation, its landing price is about 140,000 yuan. Geely Xingrui is equipped with 2.0T engines. It’s a bit surprising to think that you can buy such a hardware configuration for 140,000 yuan.

Geely Automobile Xingrui 2020 2.0T flagship model

contour design

　　Geely Xingrui adopts a family-style straight waterfall net in the front face, and it should be a set of design languages that we are very familiar with. It is gratifying that the mainstream China brands can basically come up with highly original and thought-provoking family designs. This feeling of visual unity but different details is an essential progress compared with the past.

Geely Automobile Xingrui 2020 2.0T flagship model

Geely Automobile Xingrui 2020 2.0T flagship model

　　The front of the car gives people a generous feeling, which is very similar to that of its sibling, Lingke 03, but compared with the latter, Xingrui’s transition from the hood to the front enclosure will be more natural and will not be particularly "dull".

Geely Automobile Xingrui 2020 2.0T flagship model

Size comparison between Geely Xingrui and the same class (unit: mm) car make and model long wide tall wheelbase (of a vehicle) Geely xingrui 4785 1869 1469 2800 Mg 6 4704 1848 1466 2715 Honda CIVIC 4658 1800 1416 2700 Volkswagen SAGITAR 4753 1800 1462 2731

　　Geely Xingrui has obvious advantages in body size at the same level, which is almost the largest one at the same level. Just looking at this shape does have a cross-level feeling, like a medium-sized car.

Geely Automobile Xingrui 2020 2.0T flagship model

Geely Automobile Xingrui 2020 2.0T flagship model

Geely Automobile Xingrui 2020 2.0T flagship model

Geely Automobile Xingrui 2020 2.0T flagship modelGeely Automobile Xingrui 2020 2.0T flagship model

　　The heavy feeling at the rear of the car is stronger than that at the front of the car. It should be said that from this perspective, the feeling of leapfrog will be more obvious. The penetrating chrome-plated strip at the taillight increases the horizontal visual width, and the design of "exhaust port" is not abrupt. Of course, now that it is winter, this decoration will easily reveal its identity.

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Shen Teng’s new film locks in the Spring Festival of 2021. Jason Wu wishes his friends a hundred years of harmony

The movie officially started.


1905 movie network news　On December 7th, Shen Tengliang, in Sanya, Hainan, announced the official launch of the third film "National Carnival" with Yan Fei and Peng Damo, which is scheduled to be released in the Spring Festival in 2021. Jason Wu, a good friend, also appeared on the platform of Shen Teng.

　

Group photo of the launching ceremony of "National Carnival"

National Carnival is jointly invested and produced by National Carnival Film, Xihong Film and Mahua FunAge Film. Shen Teng also officially announced at the press conference that he would join the national carnival film industry as an artistic director, and will simultaneously launch 40 episodes of the same name series project.

　

Shen Teng joined the national carnival film industry.


Jason Wu said at the scene that he envied Shen Teng. He came to Hainan in 1998 and has not found a partner so far, but Shen Teng found a good partner as soon as he came to Hainan.

Shen Teng will launch 40 episodes of the same name series simultaneously.

He jokingly sent a blessing to Shen Teng: "These two are a perfect match, they are made for each other, and they are on the ground. On such a great day, I wish you a hundred years of harmony. Your true relationship will bear fruit soon. As long as there are your works, it is a day of national carnival. "

　

Jason Wu is the platform of Shen Teng.

You Xiaogang, the director, also came to the scene to send his blessing to the series "National Carnival" which started simultaneously, and the writers of the two series also took the stage to share their expectations for the works.

　

You Xiaogang sends blessings to the series "National Carnival"

In addition to movies and drama series, National Carnival Film will join hands with Penguin Film and Television to create 10 online movies with cinema quality, each with a budget of 30 million yuan. It is understood that the first project of this online film creation plan named Plan T is "Tiger Fathers and Soldiers" jointly produced by Jason Wu Company, Chiffon Film, Penguin Film and National Carnival Film. Liang Ying, the executive producer of Wolf Warriors series, will be the chief producer of this film.

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Bao Beier frankly responded to the question of bad movies： As long as there is a play, I can play it!

Recently, actor Bao Beier’s remarks in an interview have aroused widespread concern and discussion. In the face of the question of "many bad films", he said frankly: "If there is nothing else to find me, I can play!" This sincere attitude not only makes people feel cordial, but also gives us a deeper understanding of his professional attitude.

Step 1 review events

On October 22, when Bao Beier was interviewed, the host directly threw out a hot topic: "Everyone said that many films you received were bad. Does this comment have any influence on you?" Faced with such a problem, Bao Beier did not shy away, but responded humorously: "Yes, there is no other way to find me! I can shoot whatever I can get, and I am very happy to find me to shoot. I still choose? " This sentence immediately triggered laughter at the scene, and Bao Beier’s sense of humor and true feelings instantly narrowed the distance with the audience.

2. The views of public opinion collide.

There are two totally different views on Bao Beier’s remarks. On the one hand, some people think that Bao Beier is a dedicated actor, regardless of the size of the role, he can go all out. This attitude is worthy of respect. After all, in this highly competitive industry, it is a kind of luck to be able to continue to play. On the other hand, some people criticize him for being too casual and not paying attention to the quality of his works. Frequent filming of bad films will not only affect his reputation, but also mislead the audience.

Behind these two viewpoints, people actually reflect different understandings and expectations of actors’ careers. Some people think that actors should choose scripts more carefully to ensure that each work can show their best state; Others believe that an actor needs opportunities first, and only by constantly trying and accumulating experience can he gradually improve his acting skills.

3. Deep thinking and analysis

Bao Beier’s frank response actually reveals a common phenomenon: in the entertainment circle, many actors are facing great pressure to survive. They not only have to face fierce competition, but also deal with the uncertainty of the market. In this case, it is a rare thing to be able to continue to receive work. As Bao Beier said, "Sometimes people think that actors should have their own choices, but you think, is it really up to me to decide what to play?"? In most cases, I don’t have so many choices. "

Behind this helplessness is the ecological problem of the whole industry. Driven by capital, many producers pay more attention to flow and commercial value, but ignore the quality of their works. Therefore, even a good actor can’t completely control his career destiny. From this perspective, Bao Beier’s attitude is particularly rare. He was not bothered by the external evaluation, but focused on the career he loved, and always maintained an optimistic attitude.

4. Educational significance and values

Bao Beier’s story reminds us that persistence is as important as hard work in the process of pursuing our dreams. Although not everyone can be perfect at every step, as long as you keep your initial heart, keep learning and making progress, you will always gain something in the end. At the same time, it also calls on the whole industry to pay more attention to the quality of works and provide more high-quality scripts for actors so that they can grow and develop in a better environment.

5. Summary and enlightenment

Through this interview, we saw a real Bao Beier. He didn’t dwell too much on the external evaluation, but chose to focus on his inner love. No matter how his role changes in the future, Bao Beier will continue on his own road, expecting to bring more amazing works to the audience in the future.

Finally, as a senior self-media practitioner, I sincerely suggest that you must learn to use advanced productive forces and use AI every day. It has become my working habit to use AI to generate pictures of articles, which not only helps me greatly improve my work efficiency, but also brings more traffic to my articles. I don’t think anyone, no matter how familiar you are with your business, should reject AI. Smart people have used AI tools like chatgpt, but most people in the workplace only know how to work hard, and the result is that they suffer from information occlusion. After using AI tools, you will find it very easy to start a business from the media! As long as you are willing to spend some time learning how to use it, simple operation will enable you to produce high-quality explosive pictures and texts, and it is not a dream to increase the powder by 10w+! For example, my commonly used AI tool, Simple AI, is an all-round AI creative assistant, whose functions include AI painting, literary drawing, graphic drawing, AI copywriting, AI avatar, AI material and AI design. You can generate creative beautiful pictures, anime avatars, notes on planting grass, explosion titles, activity plans, etc. with one click.

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New RAV4 Rongfang／HARRIER Lingfang is available, starting from 169,800

On September 12, 2024, FAW Toyota officially announced that its new/HARRIER was officially launched. Among them, the new RAV4 is priced at 16.98-29 7,800 yuan, the new car has been slightly adjusted for the appearance and interior, and the configuration has also been upgraded, and the continuation of 2.0L engine or 2.5L hybrid is available; while the new Ling Fang HARRIER is priced at 19.18-27 5,800 yuan, the biggest change in the new car is to be equipped with a new hybrid system, and the body hybrid logo is uniformly changed to "HEV".

At the same time, the official announced that the purchase of the new RAV4 Rongfang users, from now until September 30, new purchases enjoy up to 32,000 yuan discount, including the official drop to a high of 8000 yuan, and then enjoy the official limited-time rights of 24,000 yuan. Users who buy the new Lingfang, the official drop to a high 28,000 yuan, the whole system can enjoy 0 down payment or 50% down payment for 2 years 0 interest.

● The new RAV4 is released

The new RAV4 has been released, and the overall shape has not changed much, but there are subtle adjustments in the details. For example, the style of the front grille and the front bumper guard has been changed, the wheel eyebrows and side skirt trim strips on the side of the body will be bright black, and the rear door trim strip and rear bumper guard at the rear of the car have changed the original shape and pattern. At the same time, the main style Plus version has added an electric tailgate.

Entering the car, stitches were added to the door panels and seats, giving a more advanced feel. At the same time, the plastic around the door electronic control button area and the plastic around the shift handle were also upgraded to piano paint style. The upper part of the door armrest was added with wood grain strips, and the material was slightly adjusted as a whole.

In terms of power, the new car continues the configuration of the current model. The fuel version is equipped with a 2.0L naturally aspirated engine with a maximum power of 126 kW and a maximum torque of 206 Nm, which is matched with a CVT continuously variable transmission. The model is equipped with a 2.5L hybrid system with a maximum power of 160 kW, which is matched with an E-CVT continuously variable transmission.

● New Lingfang HARRIER

The new Lingfang HARRIER also continues the current design and adopts a beautiful and dynamic shape. The body length, width and height are 4755/1855/1660mm respectively, and the wheelbase is 2690mm. It is positioned as a medium-sized SUV. The interior of the new car also pays more attention to materials. There are a large number of leather packages in the car. The center console adopts a 12.3-inch floating central control screen, which supports CarPlay, CarLife, and Huawei HiCar car interconnection. The high-end model supports front seat heating and ventilation, and is equipped with JBL nine-speaker audio.

In terms of power, the new Lingfang HARRIER also offers 2.0L naturally aspirated engine and 2.5L power options. The 2.5L version will be equipped with a new hybrid system, and the power parameters will be adjusted. At the same time, some models will be equipped with ternary lithium-ion battery cells provided by Shenzhen BYD Lithium Battery Co., Ltd.

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Chongqing area Xingtu Lanyue is being discounted! The discount 18,000, there is no if you miss it

Welcome to Autohome Chongqing Promotion Channel, bringing you real-time car market dynamics. Now, the high-profile models are having an exciting promotion in Chongqing area. It is understood that consumers who buy Xingtu Lanyue can enjoy a cash discount of up to 18,000 yuan, and the minimum starting price has been reduced to 175,900 yuan. This opportunity is not to be missed. If you are interested in Xingtu Lanyue, be sure to click "Chatti Car Price" in the quotation form to lock in the current most competitive price and strive for higher discounts. Hurry up and don’t miss this car buying opportunity!

重庆地区星途揽月正在优惠！优惠1.8万，错过就没有

The exterior design of Xingtu Lanyue shows a strong sense of modernity and power. Its front face adopts a unique family-style design, and the air intake grille is large and three-dimensional, like a galaxy, showing the fusion of luxury and technology. The body lines are smooth, the overall style is tough and atmospheric, and the angular outline highlights the extraordinary sporty temperament, whether it is static or dynamic, it is very visual impact. The exquisite craftsmanship in the details further enhances the sense of quality of Lanyue, making it stand out among many SUVs.

The side lines of Xingtu Luoyue are smooth and dynamic, and the body size is 4970mm*1940mm*1792mm, showing a stable and atmospheric attitude. The wheelbase is 2900mm, making the interior space more spacious and comfortable. The front and rear wheel tracks are equal, 1644mm, ensuring driving stability. The tire size is 245/50 R20, and the delicate wheel design not only enhances the visual effect of the vehicle, but also ensures the superiority of driving performance.

重庆地区星途揽月正在优惠！优惠1.8万，错过就没有

The interior design of Xingtu Lanyue is full of luxury and technology. The spacious interior space is made of exquisite leather materials, providing passengers with excellent touch and comfort. The steering wheel is wrapped in leather, and it is equipped with manual up and down and front and rear adjustment functions to ensure the driver’s convenience of control. The focus of the center console is the 15.6-inch large-size touch screen, equipped with advanced automatic speech recognition control system, which can easily control multimedia, navigation, phone and vehicle functions. In addition, there are rich USB and Type-C interfaces in the car, including 2 in the front row and 3 in the back row, to meet the charging needs of passengers’ electronic devices. The main and passenger seats are equipped with heating and ventilation functions, and the driver’s seat also has an additional power seat memory, while the second row of seats supports front and rear and backrest adjustment, and has a proportional reclining function to fully meet the needs of different passengers. The interior design of Xingtu Lanyue is both practical and attention to detail, aiming to create a high-end comfortable driving experience.

重庆地区星途揽月正在优惠！优惠1.8万，错过就没有

Xingtu Lanyue is equipped with a powerful 2.0T turbocharged engine, which releases 261 horsepower and reaches a maximum torque of 400 Nm, ensuring strong performance in the car. With the 8-speed automatic transmission, the driver can enjoy a smooth gear shifting experience and efficient power transmission. This is an engine configuration that focuses on power output and driving pleasure.

Summarizing the evaluation of Autohome owners, Xingtu Lanyue has won praise for its atmospheric appearance and domineering temperament. The owner particularly emphasized the refinement of the interior and the performance of the engine, and the embellishment of the ambient light has enhanced the overall sense of technology. Compared with the joint venture car at the same price, Xingtu Lanyue shows higher cost performance. The owner believes that this is not only the pursuit of quality, but also the support of domestic brands. Xingtu Lanyue has undoubtedly left a deep impression on the owner in terms of appearance design and intrinsic value, and has become a favorite choice for the family.

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The first season of ＂Running Man＂ has ended, and Li Chen will carry on ＂seriously cute＂ to the end

Video: Chen He Heiniu "Kiss Each Other" stunned Deng Chao, Zheng Kai was played miserably by Deng Chao


The first season of "Running Man" has ended, and Li Chen will carry on "seriously cute" to the end


The first season of "Running Man" has ended, and Li Chen will carry on "seriously cute" to the end


Last Friday, the first season of Zhejiang Satellite TV’s "Run It Brothers" ended perfectly. The seven brothers who have been sweating hard for victory since 15 episodes of the program were torn in pain in the closing battle, and the original hilarious run also made the audience shout abuse. In the summary, Li Chen was praised: "Kind, serious, full of responsibility", and expressed his expectation that the second season of "Run It Brothers" could see him continue to run and deliver positive energy to the audience.


Click to watch the latest issue of "Run, Brothers": baby becomes the strongest in the first season > >


Li Chen transforms into a curious baby and will be serious to the end


In this episode of the program, Li Chen turned into Guo Jing and recreated the classic clips of the movie "Dongcheng West" with Zheng Kai. In the face of "Ouyang Kai"’s bad intentions, "Guo Jingchen" always stared at the innocent eyes and hurriedly "dishelped". A cute and innocent look made netizens call "cute", and also expressed the characteristics of integrity and seriousness vividly. In the program, Li Chen obtained the superpower "Dragon Suppressing Eighteen Palms". Li Chen, who was surprised to learn that he had such a heaven-defying stunt, nodded and sighed: "So powerful, so cool, so high, so good". The cute look of holding a little dinosaur in his hand made the audience laugh.


After the famous brand tearing competition began, Li Chen immediately turned on the aura of "technology control", first found the guide map of the science and technology museum, and learned the environmental situation of the whole building. Then Li Chen successfully activated the 18 bronze men, which can be said to be even more powerful. However, Li Chen did not take the initiative to attack his teammates, but turned into a "curious baby". In order to know Deng Chao "what medicine is sold in the gourd", the bronze men persevered and chased Deng Chao all over the floor. Li Chen said proudly: "There are my people on every floor!" The "serious and cute" feature that is wholeheartedly devoted to the game makes people laugh.


"Mother Chen" was in danger, and the curtain ended beautifully. Li Chen cried sincerely


Li Chen, who held the Eighteen Bronze Men, instinctively dominated the battlefield. Unexpectedly, he was betrayed by Chen He, who he trusted the most, and was eliminated by Wang Zulan when he concentrated on dealing with Wang Zulan. Fortunately, the magic skill of "Fighting Stars" turned back time, and everyone returned to an hour ago to start again. Deng Chaoben thought that the "Chenhe Alliance" would break up and could rest assured to form an alliance with Li Chen, but he did not expect that "Mother Chen" chose to believe that she had protected Chen He for fifteen episodes, and regardless of previous suspicions, he opened his arms and left his back to Chen He. The deeply moved Chen He kissed Li Chen’s famous brand affectionately to show his sincerity, and Li Chen immediately gave Chen He’s famous brand a kiss. Such unexpected intimacy made Deng Chao petrified on the spot, and the "Chenhe" combination joined forces again and successfully "hunted". The trust and friendship between the two was also touching.


It took nine hours to film the brand-name tearing session before the final highlight was presented to the audience. When the final decision was made, the last brand-name tearing of the first season of "Running Brothers" ended gorgeously. Li Chen couldn’t help but shed tears and hugged and said goodbye to every brother. The warm and sentimental atmosphere was very touching. "Running Brothers" has accompanied the audience through fifteen Friday nights full of laughter, and the seven brothers have become indispensable existences in the audience’s life. Li Chen said: "’Chen Ma’, ‘Serious Moe’, ‘Big Black Bull’, I can’t bear you to send me these lovely names, I can’t bear to spend 15 happy times with you, and I can’t bear to miss every friend I have met." The audience also shouted: I can’t bear to miss you, I will come back next season!

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Judge Zhao Liying’s first show and Gao Xiaosong’s chat with Muse recording program are sought after


"Creative Star" judges


Zhao Liying

　　　 Recently, the fifth season of "Creative Starry Sky", which is being broadcast on the movie channel at 6:25 every night, has entered the fierce competition in the modern clothing unit. At the same time, the mission challenges of the show have also begun to become more and more down-to-earth. A series of topics composed of new concepts on the Internet, such as "Otaku Goddess" and "Female Man", also refreshed the audience. In the "Otaku Goddess" task, Gao Xiaosong, who has the most Otaku temperament, and Zhao Liying, who has the most Muse temperament, plus Xu Jianshu, who has the most rich and handsome temperament, are paired with the most theatrical judging team.

　　　 On the same stage as Muse, Gao Xiaosong inadvertently began to respectfully call "Gao Fu Shuai" Xu Jianshu as a "local tyrant", and Xu Jianshu began to compliment the "otaku" genius Gao Xiaosong as a loser. The needles of the two Jianghu celebrities were returned, but they were completely covered up by the brilliance of the new generation of Muse Zhao Liying. When Zhao Liying appeared on the recording site of the show, the madness of his fan team really made the program team somewhat unable to resist.

　　　 However, unlike the enthusiasm of fans, Zhao Liying’s gestures reveal a restrained and humble temperament – the posture of weak Liu Fufeng, without any carving. As if to make a footnote to Zhao Liying’s brilliance. When Gao Xiaosong talked about what is an "otaku goddess", he said: Muse should be clean, reject material girls, elegant light makeup, and supple bangs are the most charming signs.


Judge Gao Xiaosong

　　　 In the program, Gao Xiaosong shared a story about teaching his grandfather to go online for the first time. His grandfather’s first request to go online was to search for a photo of Muse "Marilyn Monroe" in his mind. When Mr. Gao talked about the muddy eyes of the 80-year-old man suddenly flashing with the brilliance of a teenager, the audience was moved. Gao Xiaosong, who is not confused in his recent years, still has a spotless teenager in his heart. Because of this, he can interpret the slightly frivolous concept of "Otaku Goddess" poetically.

　　　 Students, how to counter Muse? Perhaps Teacher Gao is a role model. No matter how flashy and dangerous the world is, please take care of the spotless teenager in your heart. Boys, what is Muse? Maybe as the book says, she should be a 100% girl, maybe not beautiful, her clothes are not outstanding, and the hair on the back of her head even stubbornly leaves traces of a nap. She is walking in the vast sea of people. Thinking of her, you will be in a daze silently.

　　　 Pay attention to the fifth season of CCTV6 "Creative Starry Sky", at 6:25 pm, let’s be in a daze together before Muse appears.

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