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China Banking and Insurance Regulatory Commission: From January to April, the original insurance premium income of the insurance industry decreased by 7.84% year-on-year

  CCTV News:According to the website of China Banking and Insurance Regulatory Commission, statistics show that from January to April this year, the whole industry realized the original insurance premium income of 1,658.542 billion yuan, down 7.84% year-on-year. Among them, property insurance companies realized premium income of 404.851 billion yuan, a year-on-year increase of 16.13%; Personal insurance companies realized premium income of 1,253.69 billion yuan, down 13.6% year-on-year. The compensation expenditure was 409.337 billion yuan, a year-on-year decrease of 0.06%. The total assets of the insurance industry amounted to 17.34 trillion yuan, an increase of 3.55% over the beginning of the year.

  Specifically, the market operation presents the following characteristics:

  First, property insurance companies developed steadily and rapidly, and the proportion of non-auto insurance business increased significantly.From January to April, the original insurance premium income of property insurance companies increased by 16.13% year-on-year, and the growth rate increased by 4.26 percentage points. Among them, auto insurance business was 255.702 billion yuan, a year-on-year increase of 6.59%, accounting for 63.16% of the total business of property insurance companies; Non-auto insurance business was 149.149 billion yuan, up 37.17%, accounting for 36.84%, up 5.65 percentage points year-on-year. Among the non-auto insurance businesses, the agricultural insurance business was 18.299 billion yuan, an increase of 36.2%; Liability insurance business was 21.854 billion yuan, an increase of 34.6%; The engineering insurance business was 5.423 billion yuan, up by 27.05%; Freight insurance business was 4.405 billion yuan, an increase of 24.26%. With the rapid growth of agricultural insurance, liability insurance and other businesses, the proportion of non-auto insurance business is rising, the situation of auto insurance monopoly has changed, and the business structure of property insurance companies tends to be balanced.

  Second, the personal insurance industry actively transformed, and the business accelerated to return to the source of protection.Since the beginning of this year, life insurance companies have actively adjusted their business structure, greatly reduced the wholesale payment business and the bank-mail channel business, and paid more attention to the development of long-term savings and guaranteed products with more installment payment business and personal agency business. From the new single payment structure, from January to April, the new single payment business accounted for 45.94% of the new single payment business, up 15.12 percentage points year-on-year. From the perspective of business channel structure, personal agency business accounted for 58.93%, up 16.68 percentage points year-on-year. Although the industry transformation has continuously put pressure on business growth, the effect of structural adjustment is gradually emerging. From the monthly data, life insurance business has shown a trend of monthly recovery. From January to April, the year-on-year growth rate of original insurance premium income in life insurance business was -25.98%, -20.96%, 6.12% and 9.88% respectively.

  Third, the allocation of funds has become more stable and the investment income has grown steadily.At the end of April, the balance of funds used by insurance companies was 15,401.685 billion yuan, an increase of 3.22% over the beginning of the year. Among them, the balance of fixed income was 7,460.658 billion yuan, accounting for 48.44%, up 0.93 percentage points from the beginning of the year; Stock and securities investment funds were 1,877.341 billion yuan, accounting for 12.19%, down by 0.11 percentage points; Long-term equity investment was 1,587.133 billion yuan, accounting for 10.3%, up 0.41 percentage point. From January to April, the capital utilization income was 239.715 billion yuan, up 6.13% year-on-year, and the capital utilization rate of return was 1.57%, which was basically the same as the same period of last year. Among them, the bond income was 78.903 billion yuan, a year-on-year increase of 25.43%; Stock income was 15.55 billion yuan, down 8.34%; The income from long-term equity investment was 40.147 billion yuan, an increase of 4.19%.

  Fourth, innovation continued to be active, and Internet companies maintained a high-speed development momentum.In terms of the number of contracts, in the first quarter, the number of contracts for Internet insurance business totaled 4.096 billion, up 109.16% year-on-year. Among them, the return freight insurance was 2.002 billion pieces, an increase of 73.39%; 282 million liability insurance businesses, an increase of 42.45%; 428 million insurance businesses were guaranteed, an increase of 43.77%; Internet health insurance and accidental injury insurance were 489 million and 460 million respectively, up 41.4 times and 5.8 times year-on-year. From the perspective of Internet insurance companies, the original insurance premium income of the four Internet insurance companies from January to April totaled 4.474 billion yuan, up 85.03% year-on-year, which was 68.9 percentage points higher than the overall growth rate of property insurance companies.

  Fifth, actively play the insurance function and continuously improve the ability to serve the economy and society.Since the beginning of this year, based on the national strategy, the insurance industry has actively helped the key areas and weak links of economic and social development, helped the poor, supported innovation, broadened the funding sources of national strategies such as the "Belt and Road", and continuously improved its ability to serve the overall situation of economic and social development. From January to April, the insurance industry provided 2,354.59 trillion yuan in risk protection and more than 10 trillion yuan in financing for the real economy. From the perspective of boosting poverty alleviation, the poverty alleviation business launched by the insurance industry has achieved full coverage of 26 provincial-level administrative regions, and the number of districts and counties that have launched poverty alleviation business has reached 2083, accounting for 79.56% of all districts and counties; There are 796 poverty-stricken counties offering poverty alleviation services, accounting for 96.02% of all poverty-stricken counties. Agricultural insurance provides 1.24 trillion yuan of risk protection for 65,922,200 households; 6.748 billion yuan in compensation was paid, benefiting 7,161,800 poor households and affected farmers. From the perspective of participating in social management, liability insurance provides 229.09 trillion yuan of risk protection for more than ten fields such as environmental protection, medical care, education, transportation, food safety and safe production. From the perspective of service science and technology innovation, science and technology insurance provides risk protection for new technology research and development and high-tech product export of 403.797 billion yuan. From the perspective of providing financial support, the insurance industry directly raised 7.29 trillion yuan for the real economy by investing in bonds, stocks and funds, an increase of 4.15% over the beginning of the year; Support the "Belt and Road" through debt and equity plansThe scale of strategic investment reached 928.645 billion yuan; The strategic investment scale of supporting the coordinated development of the Yangtze River Economic Belt and Beijing-Tianjin-Hebei through the debt plan is 410.608 billion yuan and 165.499 billion yuan respectively. By the end of April, the balance of time deposits in the insurance industry was 1.49 trillion yuan, which is an important source of funds for medium and long-term loans needed for the development of the real economy.

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Candidates have increased the proportion of admission, and the new trend of 2018 is to see the college entrance examination.

  Neijiang, Sichuan, three days before the college entrance examination, senior three students took a group photo in the classroom. Bright pictures/vision china

  editorial comment/note

  The 2018 college entrance examination starts today.

  This year, the first batch boarded the college entrance examination arena after 00;

  This year, due to the integration of vocational colleges and other factors, the number of registered candidates reached 9.75 million, an increase of 350,000 over last year, the largest number of candidates in the past eight years;

  This year, many provinces have announced new college entrance examination plans. With the reform of college entrance examination, only the situation of liberal arts and science has been broken, and students’ right to choose has expanded dramatically.

  China Education Online recently released the "Investigation Report on 2018", which allows us to perceive the new changes and trends of the college entrance examination through data and charts.

  1. The proportion of admission is rising, and the contradiction of further education is basically solved.

  The number of applicants for the college entrance examination ushered in an inflection point, and the number of students studying abroad continued to rise.

  The number of applicants for the national college entrance examination dropped sharply after reaching the historical peak of 10.5 million in 2008, and it began to stop falling and stabilize in 2014. According to the statistics of the Ministry of Education, the number of applicants for the national college entrance examination in 2017 totaled 9.4 million, the same as in 2016. The number of applicants for the national college entrance examination has been stable at around 9.4 million for four consecutive years. In 2018, the number of applicants for the college entrance examination ushered in another growth, hitting a new high in eight years.

  However, in the long run, the basis of college entrance examination students has not changed fundamentally. In 2014 and 2015, the enrollment of ordinary high schools remained at the level of 7.97 million, and in 2016, the enrollment of ordinary high schools was 8.03 million, with little change. At present, the increase in the number of applicants for the college entrance examination should be mainly due to the country’s emphasis on vocational education and the continuous opening of secondary vocational education channels in various places.

  According to demographic data, the national birth rate has been declining since the 1980s. China’s birth population reached its peak in 1990, exceeding 26 million. Since then, the number of newborn babies in China has shown an obvious downward trend. In the past ten years, the number of newborns has been below 16 million for a long time. Stimulated by the two-child policy, it rose by 1.31 million in 2016, but it fell by more than 630,000 in 2017 and fell to 17 million again.

  At the same time, according to the latest data released by the Ministry of Education, in 2017, the number of Chinese students studying abroad exceeded 600,000 for the first time, reaching 608,400, an increase of 11.74% year-on-year, and continued to maintain the status of the world’s largest source country for international students.

  The admission rate has risen steadily, and many places have reached new highs.

  According to the statistical bulletin of national economic and social development in 2017 published by the National Bureau of Statistics, in the 2017 college entrance examination, there were 7.615 million students enrolled in general colleges, and the actual admission rate of the national college entrance examination reached 81.01%. The proportion of college entrance examinations in various places has been rising, and the contradiction of further education has been basically solved.

  The actual admission rate in Henan Province continues to rise.

  In 2017, the total number of applicants for the Henan college entrance examination was 865,800, an increase of 45,300 compared with 2016, still ranking first in the country. This is also the third consecutive year that the number of applicants for the college entrance examination in Henan has rebounded sharply after six consecutive losses.

  As one of the areas with the lowest admission rate in the national college entrance examination, the actual admission rate of Henan college entrance examination has continued to rise in recent years. In 2016, the actual admission rate was 85%, a record. In 2017, a total of 728,500 freshmen were enrolled, and the actual admission rate was 84.14%, which was still at a high level.

  The actual admission rate in Shandong Province is above 80% on the whole.

  According to the data released by Shandong Education Admissions Examination Institute, a total of 683,200 people (including the spring college entrance examination) took the college entrance examination in Shandong in 2017, a decrease of 26,600 compared with 709,900 in 2016. This is the first time that the number of applicants for the Shandong college entrance examination has dropped after four years of continuous increase.

  Since 2011, the actual admission rate of Shandong college entrance examination has been above 80%. 2011 — It reached a high point in 2013, then fell back and began to pick up in 2016. In 2017, the total number of students enrolled in the Shandong college entrance examination was 580,400, and the actual admission rate of the college entrance examination was 84.95%, an increase of 2.8 percentage points over 2016.

  Jiangsu Province has not completed the enrollment plan for four consecutive years.

  In 2017, the number of applicants for the college entrance examination in Jiangsu was 330,100, a decrease of more than 30,000 compared with the previous year. This is the eighth consecutive year that the number of applicants for the college entrance examination in Jiangsu has decreased, a decrease of more than 210,000 compared with 2009.

  Since the number of colleges and universities in Jiangsu ranks first in the country, in 2016, there were even more enrollment plans than applicants.

  In 2017, the total enrollment plan of Jiangsu college entrance examination was 323,600, and finally 303,400 people were admitted. The actual admission rate was 91.91%, a record high. However, there are still more than 20,000 enrollment plans unfinished, which is the fourth consecutive year that Jiangsu has not completed the enrollment plan.

  Hebei Province has achieved double growth in the number of applicants and the actual number of students admitted to the college entrance examination for three consecutive years.

  According to the data released by Hebei Education Examinations Institute, the number of applicants for Hebei college entrance examination in 2018 was 486,400, a year-on-year increase of 50,200, rising for the third consecutive year. In 2017, 401,200 candidates were actually enrolled in Hebei college entrance examination, and the actual number of students enrolled exceeded 400,000 for the first time, achieving double growth in the number of college entrance examination applicants and the actual number of students admitted for three consecutive years.

  In 2016, the actual admission rate of Hebei college entrance examination exceeded 90% for the first time, and in 2017 it exceeded 91%.

  On the one hand, the number of people admitted to the college entrance examination in Hebei and the admission rate have maintained a double growth, on the other hand, the plan of high-tech recruitment has not been completed for five consecutive years. In 2017, a total of 1,674 colleges and universities nationwide enrolled students in Hebei Province, with a total of 408,700 undergraduate and specialist programs, and 401,200 candidates were actually enrolled, with a total unfinished amount of 7,500.

  Due to various reasons, it has been common in all parts of the country to fail to complete the enrollment plan. Although the actual enrollment ratio fluctuates, it is obviously not caused by insufficient enrollment plan, but more because candidates give up the opportunity to study.

  2. The scale of independent enrollment is stable and the competition is fierce

  As an important measure of the reform of college enrollment system, autonomous enrollment expands the ways and channels of scientific talent selection, so that those students with academic expertise and innovative potential have more opportunities to receive college education.

  The admission rate of independent enrollment is at a low level.

  In recent years, with the growth of the number of self-enrollment applicants, the number of self-enrollment applicants who have passed the examination is also on the rise. According to the public information of Sunshine College Entrance Examination Platform, the number of people who passed the examination of independent enrollment in many first-class universities, including Tsinghua University and Peking University, increased in 2018 compared with the previous year.

  According to the requirements of the Ministry of Education, the number of self-enrollment can’t exceed 5% of the total annual undergraduate enrollment plan of pilot schools. Therefore, with the increase in the number of applicants and the overall stability of self-enrollment plans of colleges and universities, the competition for self-enrollment will become more intense.

  According to the public information of Sunshine College Entrance Examination Platform, the number of independent enrollment plans of Fudan University in 2017 does not exceed 155, and the actual enrollment is 58, which is 97 people different from the maximum number of enrollment plans; The number of independent enrollment plans of Zhejiang University in 2017 does not exceed 320, and the actual enrollment is 166, which is 154 people different from the upper limit of enrollment plans; In 2017, Xiamen University enrolled 262 students independently, and actually enrolled 127 students, which was 135 people different from the upper limit of the enrollment plan. Obviously, all schools are strict in the implementation of national policies and basically control them within the scope.

  Most students are willing to participate in independent enrollment.

  Although the competition for self-enrollment is becoming increasingly fierce, most students are still keen to participate in self-enrollment because of the reduction of exam difficulty and the reduction of score discrimination. According to the self-enrollment survey conducted by China Education Online for senior high school students, 80% of the students indicated that they have plans to participate in self-enrollment in the future.

  According to the survey, students’ strong comprehensive ability and expertise in some aspects are the main reasons for encouraging them to participate in independent enrollment, accounting for 60.38%.

  Zhejiang’s "Trinity" enrollment model is favored by colleges and universities.

  In 2011, Zhejiang began to try the "trinity" enrollment model in provincial colleges and universities, that is, the candidates’ scores in the national examination, the test scores of candidates in colleges and universities and the college entrance examination scores were converted into comprehensive scores according to a certain proportion, and then they were selected for admission. This recruitment model takes care of the traditional college entrance examination, middle school evaluation, college evaluation and other multi-dimensional evaluations to the greatest extent, and effectively supplements the deficiency of the traditional college entrance examination, which is favored by colleges and universities.

  In 2017, Zhejiang’s "Trinity" comprehensive evaluation enrollment, in addition to more than 40 universities in the province, there are also 8 universities outside the province and affiliated universities to participate in enrollment. These eight schools are Peking University, Tsinghua University, Fudan University, Zhejiang University, Shanghai Jiaotong University, China University of Science and Technology, University of Chinese Academy of Sciences and Chinese University of Hong Kong (Shenzhen), with a total enrollment plan of 1,554 students.

  According to the information disclosed on the enrollment websites of various schools, in 2017, Tsinghua University enrolled 150 people in Zhejiang, including 105 candidates in the "Trinity", accounting for 70%; China University of Science and Technology plans to enroll 115 students in Zhejiang in 2017, including 100 students enrolled in the Trinity Program, accounting for 86.95%. In 2017, the University of Chinese Academy of Sciences planned to enroll 41 students in Zhejiang, including 39 students enrolled in the "Trinity" program, accounting for 95.12%.

  However, considering the technical difficulty of specific practice, it is unlikely that this model will be implemented on a large scale.

  3. The pilot provinces of the new college entrance examination reform explore ways to comprehensively promote the college entrance examination reform.

  In 2017, the new college entrance examination reform successfully landed in Shanghai, Zhejiang Province, which provided useful experience for comprehensively promoting the college entrance examination reform in the next step. In November 2017, the People’s Government of Zhejiang Province issued "Several Opinions on Further Deepening the Comprehensive Reform of College Entrance Examination" (hereinafter referred to as "Opinions"). The reform scheme has been improved, especially the comprehensive and systematic adjustment of the high school academic level test, which has effectively solved the problems of class selection, examination frequency and the decline of the number of physics candidates.

  Students choose diversification, and only 10% and 17% choose traditional arts and sciences.

  The reform of college entrance examination has expanded students’ right to choose, breaking the previous limit of only two choices: liberal arts and science. According to statistics, in 2017, the number of students who chose traditional science subjects in Zhejiang dropped from 63% to 17%, and the number of students who chose traditional liberal arts subjects dropped from 37% to 10%. More students chose three elective subjects, which fully reflected individuality and diversity.

  After the reform measures of Zhejiang new college entrance examination are improved, the advantages of physics examiners are fully reflected.

  Students’ independent choice of subjects not only shows students’ personality, but also brings the problem of physics "being cold". According to the statistics of Zhejiang Education Examinations Institute, in the 2017 college entrance examination, among the 291,300 college entrance examination students in Zhejiang (250,100 students enrolled in ordinary colleges and universities, 41,200 students enrolled in separate examinations, and the number of students enrolled in examinations can only be based on the number of students enrolled in ordinary colleges and universities), the number of students enrolled in physics is 89,500, accounting for 35%.

  In the new college entrance examination held in November 2017, the number of physics students in the third year of high school in 2018 declined again. According to the data released by Zhejiang Education Examinations Institute, the number of students enrolled in the 2018 senior three exams was more than 255,000, including more than 73,000 in physics, accounting for less than 30%.

  The decline in the number of physics candidates in Zhejiang’s new college entrance examination has aroused widespread concern in society. In fact, according to the requirements for major selection of more than 1,400 colleges and universities enrolled in Zhejiang in 2014, if you choose physics, 91% of the majors are unrestricted, ranking first in all subjects. However, because of the low input-output ratio of physics, the number of students who choose physics is not as good as biology and chemistry, ranking second from the bottom.

  In November 2017, the People’s Government of Zhejiang Province issued "Several Opinions on Further Deepening the Comprehensive Reform of College Entrance Examination". According to the "Opinions", Zhejiang will establish a guarantee mechanism for elective subjects in the future, of which the number of physical elective subjects is 65,000. That is to say, once the number of students assigned to an examination of physics subjects is less than the guaranteed number, the guarantee mechanism will be started, with 65,000 as the base, and the scores will be assigned from high to low according to the prescribed proportion.

  In order to effectively guide candidates’ parents to make rational choices and promote students’ all-round development, the Ministry of Education issued the "Guidelines on the Requirements for Undergraduate Admissions in Colleges and Universities (Trial)" (hereinafter referred to as the "Guidelines of the Ministry of Education") in early 2018. At the beginning of May, Zhejiang Education Examinations Institute issued a notice, requiring that from the year of enrollment in 2020, the elective subjects of relevant majors in colleges and universities should be determined according to the Guidelines of the Ministry of Education, and some professional candidates must meet two or three elective subjects at the same time.

  According to the statistics published by Zhejiang Education Examinations Institute, among the more than 27,000 majors to be enrolled in Zhejiang in 2020, the number of majors limited to physics accounts for 22.17% of all enrollment majors. In the previously published "Scope of Selected Subjects for Majors (Classes) in Zhejiang Colleges and Universities in 2017", the proportion was only 3.9%. It can be seen that the number of physics majors required to be selected has increased significantly.

  At the same time, relevant departments have also studied and adjusted the scoring method to attract candidates to apply for "low input-output ratio" subjects such as physics, guide rational choice and grow in an all-round way.

  Under the guidance of the above comprehensive measures, the phenomenon of the decline in the number of physics candidates has been effectively curbed, and the emergence of similar phenomena in other subjects has been put an end to.

  Most candidates give up physics because of their "high difficulty and low score" and fear of losing money in admission. Judging from the actual admission situation in 2017, the candidates who took the physics exam not only did not suffer losses, but also had advantages.

  According to the data released by Zhejiang Education Examinations Institute, among the candidates admitted in the first paragraph, 59% took the physics exam. In the 985 and 211 colleges and universities, 74% of the candidates took physics, especially the undergraduate admission rate of those who took physics was 72%, which was 21% higher than that of those who did not take physics.

  Some students are utilitarian in choosing subjects, so a scientific guidance system should be established as soon as possible.

  In the new college entrance examination reform, students are given the right to choose in order to fully display their personality hobbies. However, in the actual choice, the candidates’ choice motivation is obviously utilitarian.

  In a multi-choice conducted by China Education Online for senior high school students, the number of students who choose subjects according to their academic achievements is the largest, accounting for 69.99%, followed by students who choose subjects according to their interests and hobbies, accounting for 61.47%, and students who choose subjects according to the requirements of university majors account for 42.28%.

  Choosing subjects that you are good at in order to get higher marks directly affects students’ choice of colleges and majors. According to the questionnaire survey conducted by China Education Online, 67.1% of students will adjust their target colleges or majors according to their own advantages when there is a conflict between the requirements of the subjects selected by the target colleges and universities and the subjects they are good at. Only 14.72% students will adjust their elective subjects according to the requirements of colleges and universities.

  The new high exam forces colleges and universities to do something, characteristic colleges and universities counterattack, and the enrollment pressure of non-dominant majors is great.

  The change of the examination rules has led to great changes in the admission rules, not only canceling the batch, but also emphasizing the professional characteristics in the mode of "major+university" in the new college entrance examination in Zhejiang. This new system design has effectively broken the identity boundaries of the original universities, such as 211 and 985, and provided opportunities for universities with strong discipline characteristics to surpass them.

  When Zhejiang invested in the first paragraph in 2017, some of the original "two universities" entered the first paragraph, and some of their professional investment scores even exceeded 211,985 universities.

  In the same way, the new college entrance examination also provides colleges with this possibility of transcendence. In the process of admission to the new college entrance examination in Zhejiang in 2017, some professional investment lines of many specialized colleges surpassed those of undergraduate colleges. For example, zhejiang financial college’s digital media application technology major scored 532 points, Zhejiang Medical College’s pharmaceutical equipment application technology major scored 529 points, Zhejiang Textile and Apparel Vocational and Technical College’s urban rail transit electromechanical technology major (Ningbo Metro Order Class for Urban Rail Transit Communication) scored 528 points, Tianjin Medical College’s medical imaging technology major scored 523 points, and Anhui Vocational College of Police Officers’s legal affairs major scored 520 points, all of which were 40 points higher than the second section of Zhejiang.

  The new college entrance examination not only provides counter-attack opportunities for ordinary universities with strong discipline characteristics, but also sounds an alarm for some majors with unclear advantages in high-level universities.

  In the college entrance examination in Zhejiang in 2017, there was a big gap in the professional investment scores of some former 985 and 211 universities. In the same school, the difference between the highest investment line and the lowest investment line among majors was as high as 60 points. For example, the professional score of Beijing University of Chinese Medicine is 65 points; The professional score of Northeast Normal University is 61 points; Southwest Jiaotong University’s professional score is 55 points; The professional score of Sichuan University is 49 points; China Geo University (Wuhan) scored 45 points.

  According to the statistics of admission data of some colleges and universities over the years, Southwest Jiaotong University’s admission line in Zhejiang in 2016 was 36 points (regardless of arts and sciences), and in 2017 it was expanded to 55 points (regardless of arts and sciences); In 2016, Sichuan University scored 25 points (regardless of arts and sciences) in the admission line for enrollment majors in Zhejiang, and in 2017 it expanded to 49 points (regardless of arts and sciences).

  (Author: Chai Long, Wu Fuping, editor-in-chief of China Education Online College Entrance Examination Research Center)

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How to diagnose and treat ANCA-related vasculitis? This article is too comprehensive.

Original Socrates’ afternoon tea medical rheumatism immunity channel

* For medical professionals only.

AAV is a systemic necrotizing vasculitis involving multiple organs and systems.

Recently, a summary of clinical practice on the diagnosis and treatment of ANCA-associated vasculitis (AAV) was published in Rheumatology. Let’s take a look at what dry goods are available ~

Figure 1: Screenshot of this overview.

Performance of AAV

AAV is a group of systemic vasculitis characterized by the detection of ANCA in serum, which mainly involves small blood vessels. It is characterized by full-thickness inflammation, necrosis and granuloma formation in small blood vessels.

Common symptoms can be manifested as fever, joint pain, myalgia, fatigue, weight loss, etc. When lung, kidney, gastrointestinal tract, nervous system and five senses are involved, corresponding clinical manifestations will appear. Musculoskeletal symptoms of the whole body are not specific, but they are common; The following clinical manifestations can also occur alone or in combination: chronic recurrent sinusitis accompanied by nasal scab, hollow pulmonary nodules, rapidly progressive necrotizing oligoimmune complex glomerulonephritis, multiple mononeuropathy, pericarditis or myocarditis and obvious purpura, while respiratory and renal failure at the same time is called "pneumorenal syndrome", which is an acute and severe manifestation of AAV.

Generally speaking, multiple organs and systems involved at the same time and obvious inflammatory reaction are often the key clues to diagnose AAV.

How to diagnose?

1, patient evaluation and diagnostic evaluation

When the diagnosis of AAV is suspected, a comprehensive clinical evaluation should be conducted to assess whether all the organs that may be involved are involved (see Table 1).

Table 1: Patient Assessment and Diagnostic Assessment

Routine blood tests should be carried out, and alveolar hemorrhage should be highly suspected if there is a continuous decrease in hemoglobin level.

Urine analysis is essential in finding hematuria, proteinuria and urine culture to eliminate infection, and the detection of proteinuria needs to be evaluated by quantitative urine protein/creatinine ratio.

All patients underwent chest X-ray examination. When respiratory involvement (such as alveolitis, pulmonary infiltration or nodules) is suspected, chest CT examination should be conducted in time.

When ENT involvement is suspected, CT examination of paranasal sinuses must be performed and evaluated by ENT experts (including nasal and laryngeal fibroscopy, etc.).

Electromyography was performed when peripheral nerve involvement was suspected.

In a word, it is suggested to carry out multidisciplinary examination according to the organ system involved.

2. The value of ANCA screening

It is strongly recommended to screen ANCA, and the detection of protease 3(PR3)-ANCA and myeloperoxidase (MPO)-ANCA is highly specific.

In the meta-analysis of evaluating the value of ANCA, the sensitivity and specificity of anti-PR3 antibody were 80% and 93%, while the sensitivity and specificity of anti-MPO antibody were 58% and 96%. The specificity of ANCA was different between granulomatous vasculitis (GPA) and microscopic polyangiitis (MPA), with PR3-ANCA positive accounting for 78%-87% in GPA and MPO-ANCA in MPA.

ANCA was not detected in the blood of about 10% patients with GPA and MPA, reminding us that there may be other biomarkers that have not been found when considering the diagnosis of AAV.

Besides AAV, ANCA is occasionally found in some patients with infection, other autoimmune diseases and other vasculitis.

3. When will the biopsy be performed?

Biopsy of kidney, lung, nose, nerve and muscle tissue can provide reliable evidence for the diagnosis and differential diagnosis of diseases.

The diagnostic rate of pathology may vary significantly with different biopsy sites. For example, renal biopsy has a high diagnostic rate, while paranasal sinus biopsy often suggests nonspecific inflammation.

Although biopsy is the gold standard and strongly recommended, in clinical practice, when the clinical manifestations are consistent with ANCA detection, biopsy can be omitted. In the latest classification standards of American Rheumatology Association (ACR) and European Union Against Rheumatism (EULAR) in 2022, when other diseases simulating vasculitis are excluded and diagnosed as vasculitis, biopsy is not a mandatory standard.

In short, biopsy (especially renal biopsy) should always be considered for patients suspected of active disease to evaluate the condition.

4. Classification criteria of MPA and GPA

At present, there is no diagnostic standard for AAV, so clinical manifestations, histological and laboratory data are very important for diagnosis.

Figure 2: GPA classification standard updated by 2022 ACR/EULAR

Figure 3: MPA classification standard updated by 2022 ACR/EULAR

The total score ≥5 points can diagnose GPA or MPA.

Treatment

1. Glucocorticoid

When the diagnosis of AAV is suspected, GC should be started, and the initial measurement is 1mg/kg prednisone (or equivalent) per day, or 500-1000mg methylprednisolone intravenously for 3-5 days.

PEXIVAS research shows that for critically ill patients who initially received methylprednisolone shock therapy, the GC dosage is reduced faster than that of the traditional regimen, that is, prednisone is reduced to 20mg per day within 7 weeks after starting treatment and 5mg per day within 19 weeks, which is as safe and effective as the standard dosage. The research shows that the risk of serious infection is low within one year.

LOVAS study showed that the initial remission of AAV (inanimate/severe organ involvement) was induced by GC of 0.5mg/kg/ day. As RITAZAREM study showed, the incidence of hypogammaglobulinemia (IgG<5g/L) was halved during the follow-up period.

It is mentioned that GC should be gradually reduced after induction of remission, and may be stopped gradually within the first year after diagnosis. At present, there is no high-quality evidence to support the need to maintain the optimal dose and duration of GC for AAV remission, so GC treatment should be individualized.

2. Immunosuppressive drugs that induce remission

① severe AAV

GC combined with cyclophosphamide (CTX) or rituximab is the standard scheme to induce severe disease remission at present, although more and more evidence shows that in some subgroups of patients, such as PR3-ANCA positive patients and patients with disease recurrence, rituximab is better than CTX to maintain fertility.

CTX can be administered intravenously or orally, and the dosage should be reduced in elderly patients with renal insufficiency. The dosage of 15mg/kg is selected according to the most widely used CYCLOPS regimen in Europe. Compared with the daily oral regimen (2mg/kg/d), the cumulative dosage of CTX can be reduced by 50%, and the remission rate is similar, while the end-stage renal disease, adverse events or survival time have not increased, but the risk of disease recurrence has increased in the long run.

The two regimens usually stop taking drugs 3-6 months after remission, and then start maintenance treatment.

Rituximab (375mg/m2 per week, four times in total or 1000mg twice every two weeks) is not inferior to CTX in inducing remission, and it is more advantageous in PR3-ANCA positive or recurrent patients.

There is little evidence to compare CTX with rituximab in patients with low glomerular filtration rate (< 20 ml/min/1.73m2). According to the suggestion of KDIGO guidelines in 2021, in addition to the first and third intravenous use of 15mg/kg CTX, such patients can also choose to use 375mg/m2 of rituximab combined with CTX for four consecutive weeks. However, this combination may bring additional risk of infection, and a recent retrospective study showed that rituximab alone may be as effective as CTX in inducing remission in patients with eGFR<30ml/min/1.73m2.

In all patients, compound sulfamethoxazole should be taken orally for at least 3 months after the last use of CTX to prevent pneumocystis carinii pneumonia (atrovaquinone or pentamidine aerosol should be used in case of intolerance/allergy) until B cells are rebuilt after rituximab treatment.

② Non-severe AAV

For non-serious disease-induced remission, rituximab is more effective than conventional immunosuppressants, and MTX and MMF can be used as substitutes when rituximab or CTX cannot be used. Studies have shown that MTX and MMF are not inferior to CTX in the remission rate of 6 months, but the recurrence rate during follow-up is higher than CTX, especially in PR3-ANCA positive patients.

3. Immunosuppressive drugs to maintain remission

After CTX or rituximab combined with low-dose GC induction therapy, rituximab (500 mg every 6 months) is superior to azathioprine in the maintenance and remission of GPA and MPA. It has been proved that the maintenance treatment of rituximab (1000mg once every 4 months) is safe and effective in patients with recurrence. For patients with contraindications to rituximab, AZA or MTX can be considered as alternative therapy.

On the other hand, the use of rituximab may lead to hypogammaglobulinemia and increased risk of infection, so it is suggested to use low-dose rituximab to maintain remission. In clinical practice, not only drug safety but also the risk of disease recurrence should be considered.

AZA(2mg/kg/ day) and MTX(0.3mg/kg increased to the maximum of 25mg/ week) have similar effects on maintaining remission of AAV, and they are second-line drugs for maintaining remission. Patients with impaired renal function (eGFR<45ml/min) should avoid using MTX.

At present, EULAR recommends maintaining treatment for at least 2 years, and recent studies using rituximab or AZA regimen show that immunosuppressive treatment for more than 2 years can reduce the recurrence rate of the disease.

4, plasma exchange and complement C5 receptor inhibitors

PEXIVAS research shows that routine plasma exchange treatment for severe GPA/MPA patients with glomerulonephritis (eGFR<50ml/min/1.73m2) or alveolar hemorrhage has no benefit. This result is contrary to the previous MEPEX1 study, which may be due to the stricter inclusion criteria of the latter [creatinine (> 5.8mg/dl) and glomerulonephritis confirmed by biopsy are required]. The subgroup analysis of PEXIVAS study showed that plasma exchange did not benefit significantly in these subgroups.

Meta-analysis published recently shows that plasma exchange at the age of 12 months in patients with severe renal disease may be beneficial to the prognosis of kidney if the infection rate is high.

Therefore, even with severe renal disease, the use of plasma exchange is still controversial, and it is not recommended as a routine treatment.

It is worth noting that the position of international guidelines on plasma exchange of AAV is quite different. The KDIGO Alliance recommends plasma exchange for patients who need dialysis or whose creatinine increases rapidly > 500 mol/L (> 5.8 mg/DL), or for patients with severe hypoxemia and alveolar hemorrhage, while the 2021 ACR guidelines suggest that plasma exchange is not recommended for patients with active AAV glomerulonephritis or alveolar hemorrhage. EULAR 2022 suggested that plasma exchange should be considered in patients with rapid increase of creatinine > 300μmol/l, but there is no evidence that routine plasma exchange can treat alveolar hemorrhage.

Recently, in addition to CTX or rituximab, avacopan, an oral complement factor C5 receptor inhibitor, has been approved and licensed for the induced remission and maintenance treatment of severe AAV, in order to replace or limit the dosage of GC.

So which patients will benefit the most from this new treatment, especially considering the cost of the drug, is still worth discussing.

According to the study of its mechanism of action, avacopan seems to be the most useful for patients with severe kidney disease and alveolar hemorrhage, as well as patients with high risk of GC-induced comorbidity, including the elderly.

summary

When the patient is highly suspected of AAV, further ANCA detection is needed, and all organs are evaluated, and if necessary, tissue biopsy is performed to make a definite diagnosis.

Clinical treatment strategies should vary according to the severity, age, weight, complications and prognosis of AAV.

Recent studies support rituximab as the first choice to induce and maintain remission.

In addition, compared with the conventional scheme, a small amount of GC is equally effective and safer in inducing remission.

There is insufficient evidence to support the routine use of plasma exchange for treatment.

References:

Baptiste Chevet, Divi Cornec, Marta Casal Moura, Emilie Cornec-Le Gall, Diagnosing and treating ANCA-associated vasculitis: an updated review for clinical practice.[J] Rheumatology.

This article is the first channel of rheumatism immunity in medical field.

The author of this article is Socrates’ afternoon tea.

This article reviews Chen Xinpeng, Deputy Chief Physician.

Responsible editor, cassette tape

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This article is original. If you need to reprint it, please contact authorization.

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Donnie Yen won the achievement award of Asian Chaplin filmmakers. The new film challenges martial arts.

 1905 movie network news A few days ago, the "Asian Chaplin Filmmaker Achievement Award" was held at an award ceremony, and an international action superstar who was famous at home and abroad for his "Ip Man" series won the award. Previously, filmmakers such as,, and have also won this award.


Donnie Yen said at the award ceremony: "Chaplin is a role model for filmmakers, especially for directors and actors of action movies. I am honored to be recognized by this award, and I also use this award to spur myself to continue to explore and try in the film in the future and shoot more and better works. "


Film achievements are recognized. Donnie Yen "spurs himself with awards"


The Chaplin Award was established in 1972, named after a comedian. It is awarded every year to a filmmaker who has made long-term contributions to the film art on a global scale and has great influence. As the winner of this award, Donnie Yen also expressed his reverence for Chaplin after winning the award. He said: "Charlie Chaplin is a real master in the history of film, and he has inspired every actor, filmmaker and artist all over the world. He is a role model for filmmakers, especially for directors and actors of action movies. " He also said modestly, "I am honored to be recognized by this award, and I will use this award to spur myself to continue to explore and try in the film in the future and shoot more and better works."


Donnie Yen’s action movies are well received at home and abroad. Whether as an actor or as an action director, Donnie Yen has proved his strength in action movies. "Ip Man" series let more people see China Kung Fu, which was directed by Donnie Yen and acted as producer and action designer. In 2021, it won the box office champion of Chinese action crime movies.


The new film creates a new world of martial arts, attracting mainstream foreign media to report first


Recently, Donnie Yen has been the general director, starring and producer. At present, the film has been reported by three foreign mainstream media. Donnie Yen said that in order to present a better action scene, the "Zhenjiaban" was also dispatched by all staff. He has worked with Zhang Yimou in many martial arts films. He thinks that in recent years, because of the addition of too many special effects, the martial arts characters on the screen have gradually lost their sense of reality. After shooting different action films at home and abroad, he shoots martial arts themes. He thinks it is time to find a source and sense of reality. "If you ask me what style this action will be, I will say it’s Donnie Yen style. I want to use real martial arts moves to let the audience feel the sense of power in the role fighting through the pictures of the movie, which will produce the shock of the pictures." Donnie Yen revealed that "The Legend of Dragon in Qiao Feng" is already in the post-production, and he will try his best to make action sense in terms of special effects, hoping to present a more realistic martial arts world and Qiao Feng with Donnie Yen characteristics to the audience.

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Carrying out meteorological disaster risk survey can promote the development of meteorological disaster risk early warning business.

     Cctv news: On May 18th, the State Council held the first national conference on comprehensive risk survey of natural disasters. In response to a reporter’s question, Wang Zhihua, Director of Disaster Reduction and Public Service Department of China Meteorological Bureau, said that in this natural disaster risk survey, the meteorological department undertook the risk survey of nine meteorological disasters, including rainstorm, drought, typhoon, high temperature, low temperature, wind hail, snowstorm, lightning and sandstorm, among which the wind hail disaster covered strong wind, hail and tornado. China Meteorological Bureau concentrated the excellent expert resources of the whole department, set up an expert group, mobilized the professional and technical backbones of meteorological departments at the national, provincial, municipal and county levels, and actively carried out the risk survey of meteorological disasters. At present, it is being actively promoted and some pilot results have been achieved.

  Wang Zhihua pointed out that it is of great significance to carry out meteorological disaster risk survey to improve disaster prevention and control capabilities.

  On the one hand, we can better find out the risk points, risk areas and disaster thresholds that may be caused by all kinds of disastrous weather. To promote the development of meteorological disaster risk early warning business, we can not only predict tomorrow’s weather, but also predict what impact such weather may have, and where the risk of disaster is high and needs to be guarded, thus promoting the transformation from disastrous weather forecast to meteorological disaster risk early warning, greatly improving the pertinence of early warning information, helping to better play the role of the first line of defense for meteorological disaster prevention and mitigation, and providing stronger support for comprehensive disaster prevention and mitigation.

  On the other hand, the meteorological disaster risk zoning formed by the census can guide the whole society to scientifically set meteorological disaster prevention standards for infrastructure in various regions, which is more conducive to promoting the construction of resilient cities and resilient villages and fundamentally improving the ability to resist various meteorological disasters.

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Beijing urban management changes new uniforms, and each player has a number on his chest.

  Since yesterday (October 1st), the city’s urban management team members in Beijing have started to carry out law enforcement inspections with new uniforms. Recently, the Municipal Urban Management Law Enforcement Bureau has uniformly renewed the uniforms and signs of law enforcement personnel in the city’s urban management system. On the first day of the Eleventh Golden Week, the city’s environmental order was good. During the festival, all urban management and law enforcement departments will take a break and take up their posts, focusing on strengthening the prevention and control of bustling commercial districts and characteristic blocks, major transportation hubs, large-scale gatherings, activities and other crowded areas.

  After asking the way, the tourist said, Have you changed your uniforms?

  "Have you changed your uniforms?" Yesterday morning, outside the East Palace of the Summer Palace, Mr. Li, who was traveling from Hebei to Beijing, was surprised after asking the urban management team for directions. He said: "I mainly asked the city management for directions in the Bird’s Nest two days ago, and the answer was very detailed. I still have an impression of the previous uniforms."

  Beijing Youth Daily reporters saw in Qianmen and the Summer Palace and other popular National Day attractions that all urban management team members have put on new uniforms and started to perform their duties. The clothing color is navy blue, with a golden logo, and each team member’s number is on the chest.

  According to reports, the new uniforms mainly consider adapting to the fact that urban management law enforcement workplaces are mostly outdoors and on the streets, which is convenient for duty activities. This is also the requirement of the Municipal Urban Management Law Enforcement Bureau to implement the "Administrative Measures for the Supply of Clothing and Signs for Urban Management Law Enforcement" by the Ministry of Housing and Urban-Rural Development, strengthen the construction of urban management law enforcement teams, and further promote standardized and civilized law enforcement.

  Solve the problem of people who are not empty in the three-meal car

  After the flag-raising ceremony yesterday morning, crowds poured into Qianmen area, and the law enforcement team members of Dongcheng Urban Management began to guide the crowd. According to reports, in view of the relatively dense number of tourists watching the flag-raising during the holiday season, Dongcheng City Management has sent six law enforcement teams to strengthen the deployment in Qianmen Arrow Tower, Qianmen East Street and Chang’ an Avenue from 5: 00 every day, and sell tourist goods to the following tourists. Personnel engaged in unlicensed catering will be disposed of promptly and quickly.

  在东城,每天将有300余名队员巡查在全区各个街道和社区,发现各类问题及时解决。在簋街、南锣鼓巷及北京站等重点地区,更是每天32个车组全天连续14小时定人定岗盯守,队员一日三餐均在执法车内解决,确保每个时段岗位不空人。

  节日期间 北京城管全员停休

  为确保今年国庆期间环境秩序良好,节日期间城管执法部门全员停休,全员上岗,实名管控,重点对无照经营、非法运营、非法小广告、占道经营、店外经营、非法停车场等环境秩序问题进行查处,全面遏制重点地区环境秩序类问题。

  黄金周期间,城管执法部门重点加大对天安门及周边地区、长安街沿线,故宫、奥林匹克公园、什刹海、恭王府、八达岭、十三陵及市属11大公园,繁华商业区和特色街区,主要交通枢纽,大型集会、活动等人流密集地区的防控力度。同时对违规户外广告、牌匾标识、夜景照明、山寨指路牌、临窗广告以及车身广告等,及时督促责任人进行拆除、清理、维修或更换,对附带电话号码的,及时进行警示提醒。

  According to the person in charge of the Municipal Urban Management Law Enforcement Bureau, the management of construction sites will continue to be strengthened during the festival, and the construction enclosures in key areas will be checked according to the specifications, and the construction dust will be strictly controlled, and the management of construction waste transportation will continue to be strengthened to prevent road spillage; Increase the control of illegal activities such as open-air barbecue, burning garbage and white pollution. Visit and investigate the gas supply, users, kitchen waste generation and collection and transportation units around the key security areas one by one, and rectify the problems.

  Urban management volunteers help serve tourists.

  In addition, the urban management law enforcement departments, in conjunction with the Beijing Urban Management Volunteers Association, set up publicity service stations for urban management law enforcement in tourist attractions and window areas during the National Day to monitor the environmental order and provide tourists with services such as inquiries, directions and simple medical care.

  Yesterday, in Qianmen Street, Nanluoguxiang Pedestrian Street, Summer Palace and other areas, volunteers organized by urban management departments participated in the publicity of laws and regulations, stopped uncivilized behavior, and provided some services urgently needed by tourists, such as directions.

  The person in charge of the Municipal Urban Management and Law Enforcement Bureau said that mobilizing members of the association, volunteer groups and the general public to actively participate in the maintenance of holiday environmental order, especially guiding social units in key areas to actively participate in environmental governance and rectification, can jointly create a beautiful and clean urban environment.

  Text/Reporter Li Tao

  Photography/Reporter Wang Zhenlong Cui Jun

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Shen Teng’s new film locks in the Spring Festival of 2021. Jason Wu wishes his friends a hundred years of harmony

The movie officially started.


1905 movie network news On December 7th, Shen Tengliang, in Sanya, Hainan, announced the official launch of the third film "National Carnival" with Yan Fei and Peng Damo, which is scheduled to be released in the Spring Festival in 2021. Jason Wu, a good friend, also appeared on the platform of Shen Teng.

 

Group photo of the launching ceremony of "National Carnival"

National Carnival is jointly invested and produced by National Carnival Film, Xihong Film and Mahua FunAge Film. Shen Teng also officially announced at the press conference that he would join the national carnival film industry as an artistic director, and will simultaneously launch 40 episodes of the same name series project.

 

Shen Teng joined the national carnival film industry.


Jason Wu said at the scene that he envied Shen Teng. He came to Hainan in 1998 and has not found a partner so far, but Shen Teng found a good partner as soon as he came to Hainan.

Shen Teng will launch 40 episodes of the same name series simultaneously.

He jokingly sent a blessing to Shen Teng: "These two are a perfect match, they are made for each other, and they are on the ground. On such a great day, I wish you a hundred years of harmony. Your true relationship will bear fruit soon. As long as there are your works, it is a day of national carnival. "

 

Jason Wu is the platform of Shen Teng.

You Xiaogang, the director, also came to the scene to send his blessing to the series "National Carnival" which started simultaneously, and the writers of the two series also took the stage to share their expectations for the works.

 

You Xiaogang sends blessings to the series "National Carnival"

In addition to movies and drama series, National Carnival Film will join hands with Penguin Film and Television to create 10 online movies with cinema quality, each with a budget of 30 million yuan. It is understood that the first project of this online film creation plan named Plan T is "Tiger Fathers and Soldiers" jointly produced by Jason Wu Company, Chiffon Film, Penguin Film and National Carnival Film. Liang Ying, the executive producer of Wolf Warriors series, will be the chief producer of this film.

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30,000 domestic Harley 1200, is it worth buying?

pay close attentionLocomotive network, every nightseventeen past nineminute

JC junTalking about motorcycles with you

Brothers, when generate was a domestic large-displacement model, a new cruising car-Xinyuan Zhui1200 was launched in China last year, and this domestic Harley will also be reduced in price.

Zhui1200 has launched a price reduction promotion in the last two months, although it is officially sold. The price is still above 45,000, but there is feedback from riders, and the promotional price of some offline stores has reached around 38,000.Some even came to 35,000.

Of course, the above part of the vigorous promotion is only the behavior of some dealers, so I won’t discuss the reasons.

The biggest highlight of Xinyuan’s public upgrade cruise is that it is equipped with a 1200cc V-type twin-cylinder engine, which can output 80N·m torque at 3000 rpm. This power platform is suspected to come from Harley, which is famous for cruising. When the new car came on the market, even riders said that they bought an engine to send the car.

Equipped with front and rear double-loop shock absorbers, the front is vertical shock absorption, and the back is multi-section adjustable spiral spring structure; The braking part is the front double disc+unknown calipers, and the safety auxiliary system includes ABS and TCS systems. The fuel tank capacity is 14L, and the feedback from riders is that the fuel consumption per 100 kilometers is between 6.0 and 7.0L..

Compared with other 1200cc models of the same displacement class on the market, the starting price of Xinyuan’s 12.04 million yuan is more cost-effective. However, if you want to start this public upgrade model, you may have to consider more than the price ~

Are you the owner of Xinyuan Zun 1200?

Or have you ever ridden this public upgrade cruise?

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Shared power bank: Market competition is not a zero-sum game – Interview with Liu Tongxin, inventor of shared charging technology

  Recently, a "love sharing station" has been unveiled in major subway stations in Qingdao one after another. It not only provides passengers with a number of convenient services such as shared power banks, shared umbrellas, paper towel sales, and subway morning newspapers, but also provides emergency medical supplies such as medical kits and defibrillators. Once the machine was launched, it was well received by many passengers and praised it one after another.

  The inventor of this project is Liu Tongxin, who is known as the innovation expert. Before that, he had invented and incubated more than a dozen innovative products such as hotel gathering multimedia systems, flexible screen laptops, and mural TVs. In recent years, what has made him famous is undoubtedly his original shared power bank technology solution and business model. "In 2014, I laid out more than 20 shared power bank patents. This is the earliest batch of patents in the field of shared power banks, and three of them are core patents." Liu Tongxin said that due to his original innovation and patent layout in the field of shared power banks, he is known as the "father of shared power banks".

  Creativity comes from a trip to the United States

  Liu Tongxin’s idea for the shared power bank project originated from a visit to the United States. In June 2014, Liu Tongxin followed a delegation to the United States to investigate innovation and entrepreneurship projects. One night, while he was out, his mobile phone and power bank were dead, which inspired him to invent a shared charging model.

  "I thought at that time, if there is a box, I can put the power bank that is dead and replace it with a power bank with electricity, which can solve the charging needs of many users." Liu Tongxin believes that mobile phone users have a rigid demand for battery power in public places, and with the increasing number of smartphone users, the number of users sharing power banks will show a rapid growth trend.

  With the idea of "shared charging", Liu Tongxin began to implement it. On the plane back to China, he designed a complete set of technical solutions for shared power banks. After returning to China, he immediately organized the technicians in the laboratory to set up a research and development team to start developing this technical solution.

  At the same time as the technology development, he carried out patent layout. "For this project, we have submitted more than 20 patent applications and have been authorized successively. Among them, three patents are the core technologies in the field of shared charging, and their names are’An identifiable mobile phone rechargeable battery and its identification method ‘ (patent number: ZL201410666867.0),’ A mobile phone battery charging replacement system and charging method ‘ (patent number: ZL201410667099.0),’ A mobile phone battery charging case ‘ (patent number: ZL201410667122.6). This is the first batch of shared power bank patents, which is a real process from 0 to 1, and most of them are invention patents." Liu Tongxin said.

  Product landing encounters confusion

  In November 2014, Liu Tongxin began planning how to turn the drawings into real objects. Since there were no companies in Qingdao that produced power banks, he decided to send the R & D team to Shenzhen to seek partners for power banks.

  In Shenzhen, the R & D team has reached a cooperation intention with a number of power bank manufacturers. When the two sides communicated the technical details, the engineers of the R & D team informed the other party of the technical solution, and later, they also showed them the patent application documents.

  Liu Tongxin said: "At the end of 2015, I found shared power bank cabinets produced and launched by a Shenzhen Technology Co., Ltd. in several shopping malls in Shenzhen one after another. This was exactly the same as the technical solution of the shared power bank I designed. This surprised me very much. I realized that the technical solution may have been leaked. After I conducted a patent search, I found that this company submitted a large number of utility model patent applications after I submitted the patent application, and this company was raising money everywhere. It kept claiming to investors that they invented the shared power bank. This made me very angry. At that time, I especially wanted to take up legal weapons to protect my legal rights and interests. Later, this company launched several lawsuits against other shared power bank companies."

  Look for partners cautiously

  With the advent of the sharing economy boom, the business model of shared charging has gradually been recognized by the market, and the number of entrants has increased rapidly. As the inventor of shared power banks and the holder of core patents, Liu Tongxin is also known to more and more people. Many companies have come to seek cooperation, hoping that he can transfer the patent of shared charging to them. He told reporters: "The technical solutions used in the entire power bank industry are inseparable from my three core patents."

  In this regard, Liu Tongxin had his own considerations. He hoped that his partners would be companies with big ideas, and he did not want patents to become a tool for corporate competition. After repeated consideration, he finally chose to cooperate with Shenzhen Street Electric Technology Co., Ltd. (hereinafter referred to as Street Electric).

  Liu Tongxin believes that the market size and scale of Street Power and its strong financial strength can better translate his patented technology into products. "I hope to promote the development of this industry together with leading enterprises," Liu Tongxin said.

  Businesses should promote innovation together

  Standing in the trend of the sharing economy, shared power bank enterprises have been able to develop rapidly, but at the same time, the market competition in this field has become increasingly fierce, and patent disputes have also arisen. It is understood that, taking Street Electric as an example, there have been dozens of cases of patent infringement sued by Shenzhen Caller Technology Co., Ltd. (hereinafter referred to as Caller).

  Since March 2017, Caller has initiated more than 30 patent infringement lawsuits against Jiedian in Shenzhen, Beijing, Guangzhou and other places, with a total amount of tens of millions of yuan. In addition, Caller also filed an injunction application with the Guangzhou Intellectual Property Court, asking the court to order Jiedian and others to stop the alleged infringement first.

  In response to the lawsuit of the caller, Street Electric filed a request for patent invalidation on 7 patents of the caller, and the original Patent Reexamination Board made a review decision after the trial, of which 5 patents were claims of infringement that were declared invalid, 1 patent was claims of infringement that were declared partially invalid, and the other 1 patent was found not to be creative by the court in the administrative litigation of invalidation, and the original Patent Reexamination Board was ordered to make a new review decision.

  In addition, Jiedian believes that Caller has filed 30 patent infringement lawsuits with the Beijing Intellectual Property Court and the Shenzhen Intermediate People’s Court (hereinafter referred to as the Shenzhen Intermediate People’s Court) on the basis of the same 6 patents. These 30 cases have the same parties; and the rights basis on which these 30 lawsuits are based are all the same 6 patents. In particular, the alleged infringing products involved in the 24 cases filed in the Shenzhen Intermediate Court are all the same type of cabinet products of Jiedian, which belong to the same litigation object. Jiedian believes that this is a typical duplicate lawsuit. Caller believes that it is not a duplicate lawsuit. At the same time, Jiedian believes that Caller is also suspected of spreading misinformation and misleading information, which is an act of unfair competition.

  After the trial, the Shenzhen Intermediate Court ruled that Street Electricity’s lawsuit was established, requiring the caller to immediately stop the unfair competition, publicly apologize to Street Electricity on its official website, WeChat official account and more than ten media for the unfair competition, eliminate the negative impact, and compensate Street Electricity for economic losses and reasonable expenses of 5 million yuan. At present, the case is in the process of 2nd-round Moderation.

  Regarding these patent disputes, Liu Tongxin believes: "The purpose of enterprises to carry out patent layout should be to build their own protective’armor ‘, rather than maliciously attack others."

  "The market competition in the shared power bank industry should not be a zero-sum game, and the relationship between enterprises should be mutual promotion and common progress." Liu Tongxin said that at present, there is still a lot of room for innovation in the shared power bank industry in our country, and the shared power bank enterprises should focus on technological innovation, provide users with better services and create higher value. Only in this way can the entire industry develop better. (Intellectual Property News, Andy)

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Dog’s blood cheating is a spy war style. After 12 years, it’s impossible. Will Huang Lei’s wife still play it?

The return of the fairy sister ignited the retro craze of Chinese drama.

Legend of the Sword and the Chivalrous Man is not only a fairy in Liu Yifei, but Zhao Linger’s mother, Empress Wu, was also the goddess of that year.

Sun Li, who has been in the cinema for many years, returned to the screen and performed a "Wife’s Choice".

There are spoilers in this article.

one

Sugar cube is not happy recently.

Mao Mao, Shiba Inu, who has been with him for many years, is lost. This puppy is an important family member to Fang Tang who has not given birth after ten years of marriage.

After posting the dog-seeking notice for several days, the sugar cube began to accept the reality.

Today is very important for her husband, Gao Jiawei. She must cooperate with her husband to attend the event, and there is no way to delay any longer.

Gao Jiawei is a self-made entrepreneur from the media. As an opinion leader on emotional topics, he often competes with another emotional expert Qi Miao to explain emotional issues from different perspectives of men and women.

Looking at the speech on her husband’s computer, I couldn’t help but quietly polish the itchy sugar cube.

In fact, after becoming a full-time wife, Fang Tang has been working as an amateur detective novel writer, thanks to her good writing style.

When Gao Jiawei recited his wife’s wonderful ideas on the stage, Fang Tang also dressed herself up and prepared to go to her birthday party, the most important occasion today.

It was supposed to be a couple’s world, but after Gao Jiawei founded the company, the sweet wife-pampering day was also added with more performance factors. After all, a good leader who cares for his family can better win people’s hearts.

Out of support for her husband’s work, Fang Tang has never been dissatisfied with this. She attends as a model wife every year and enjoys the "surprise" arranged by her husband.

But when Fang Tang saw Gao Jiawei coming out of the bathroom, the lipstick mark on her husband’s shirt collar caught her alarm.

Gaos thought for consternation explained that it may be a drunken woman at the door of the bathroom.

But how close does a stranger have to be to leave lipstick in such an ambiguous place?

As a wife’s vigilance, sugar cube walked carefully every step. She smiled and walked to her husband’s preset stage, while carefully observing the red number of every lady present.

She knows that something must have happened, and a woman’s perception can’t be wrong.

In fact, Fang Tang had seen the luxury goods receipt in her husband’s pocket before. As a detective novel author, she had long been wary.

Did the husband cheat? Who is the third party?

Following the clues, Fang Tang became a detective of her marriage and began to deal with her husband in a seemingly peaceful pregnancy life.

2

Spy war, suspense and family ethics drama, a drama contains the above three popular elements, and Wife’s Choice may be the first one.

From the professional setting of Fang Tang, it can be seen that "Wife’s Choice" wants to fight hard. In the serial novel "Fatal Gentleness", she replies to the reader as an author, which is like a big V gesture.

Sugar cube found her husband reading the novel, but when asked about the work, the other party said that the author’s writing was not as good as sugar cube’s.

Obviously, the husband doesn’t know his wife’s pen name, and he doesn’t know her writing style well enough.

And husbands hide more secrets from their wives.

However, a good play needs a good rhythm. "Is the husband cheating" has become the biggest suspense at present, and the director has made the audience think that all the girls swept by the camera may be a third party.

Seeing Qi Miaobei’s luxury bag, Fang Tang confirmed several times where the other party bought it, because she suspected that it was her husband’s bill.

Seeing the lovely earphone left in her husband’s car, Fang Tang teased which young girl’s belongings it was, but her husband used jokes to avoid it.

Seeing the necklace of a young female subordinate, Fang Tang pretended to be enthusiastic and asked about the brand and added WeChat. After all, everyone was suspected.

His wife quietly investigated, and Gao Jiawei, as an emotional expert, also knows the appeasement policy and the push-pull relationship, candlelight dinner, surprise gifts, wedding anniversary plus pregnancy preparation, and even created a more loving husband and wife life than before.

However, the Smiths’ performance will eventually reveal the truth. When Sugar Cube finds out that she has been betrayed, it is the wife’s choice whether to destroy her husband’s name as an emotional expert or sacrifice herself to whitewash it, which is also the prelude to the next catch me if you can.

When betrayal and doubt begin, marriage has come to an end.

three

As an important work of Sun Li’s return to the small screen, Wife’s Choice has a good script design and is adapted from the novel of the same name by writer Wang Xiaoqiang.

The subtlety is that it knows how to analyze women’s psychology with the cloak of suspense, including the breakup of life.

There are full-time wives represented by sugar cubes, strong women in the workplace represented by Qi Miao, and women with love anxiety represented by heavy rain. Around the wall of marriage, women’s joys and sorrows are presented one by one, and everyone’s growth arc is also displayed.

What’s more, there are only 12 episodes of "Wife’s Choice". To complete the three things of husband and wife’s battle, truth and self-growth, the director needs a strong rhythm to control.

In the first half of the series, many suspenseful and necessary details are added, but whether we can take into account the detailed proportion of several lines still needs further observation.

The intrigue of the husband and wife from the details also has higher requirements for the actors. Just how to lie without changing color requires performing at all levels.

Sun Li removed the label of "Huang Lei’s wife", and fans wondered whether the real housewife who returned to the screen after 12 years had regressed.

It must be admitted that there is a certain age difference between the 44-year-old Sun Li and his wife in her early 30 s, but her relaxed and relaxed interpretation still makes people believe that she was not only lucky when she debuted.

Yuan Wenkang, the supporting husband, has played many roles in love rat before, but this time, the hypocritical liar is set up by everyone, and he is also good at it.

In addition, Zhang Yao, Wang Zhen, Ma Yinyin ("Hunting Crime Picture Book"), Zhao Da, Liu Yiwei and Wu Bi joined in, which also accumulated some interesting points for the team.

"Wife’s Choice" turned the middle-aged dog blood drama into a suspenseful twist, but there are inherent type barriers. Whether this unconventional transformation can be completed is far from being revealed.

It can only be said that Sun Li, who came back, and Wife’s Choice, who jumped out of the genre framework, are brave adventurers, testing the water for the whole industry, first to see if the spring of middle-aged actresses has recovered, and second to see if sincere creativity can be recognized, and the standard for testing everything is always in the hands of the audience.

The picture in this article comes from the Internet.

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