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Nature ｜ Bioaccumulation of therapeutic drugs by human intestinal bacteria

What is Bioaccumulation?

What do you get when you decompose the term "bioaccumulation"? The word accumulation meansSomethingThe accumulation of, and the prefix bio- meanlife. Put it together, it is.Something accumulates in living things.To defineBioaccumulation.

Then biological accumulation is used to refer toChemical substances in organismsThe accumulation of. These substancesCann’t be metabolized , it accumulates in organisms and accumulates through the food habits of consumers at all levels in the food chain.The higher the level, the higher the cumulative concentration in the body of consumers.The phenomenon.

How does bioaccumulation occur?

One way is to let a certain amount of chemicals enter the organism.Faster thanThe rate at which organisms decompose and use it. This means that more chemicals enter than are discharged, leading to the accumulation of chemicals in organisms.

Another main way is that chemicals enter organisms, and organismsIt cannot be decomposed or excreted in some way.. So chemicals will continue to accumulate,Until it eventually becomes fatal to organisms..

All organismsThe problems we face are allThe result of dynamic balance between absorption and elimination. biological accumulationThe degree of occurrence determines the toxic effect.. In some cases, the protection mechanism is protected from certain undesirable substances deposited in special parts to prevent them.Participate in metabolic reaction.

The bioaccumulation description in this paper is used to evaluate the accumulation of drugs and their harmful metabolites in intestinal bacteria.

Therapeutic drugs will have a strong impact on intestinal microflora, and vice versa.Potential drug-bacterial interactions can be mediated by biologicalTransformation reduces microbial adaptability or changes drug availability.. The latter can have a positive or negative impact on drug activity and efficacy. Although drugs such as lovastatin and sulfasalazine will be chemically affected by intestinal bacteria.Convert into active formBut bacterial metabolism can make digoxin and so on.Drug inactivation, or like irinotecan (irinotecan).toxic effect. In order to further increase the diversity of susceptible drugs, it was recently reported that more than 100 molecules were chemically modified by intestinal bacteria.However, the mechanism of these interactions is mainly limited to drug biotransformation..

Lovastatin (lovastatin)

Lovastatin can reduce the synthesis of cholesterol and increase the synthesis of low-density lipoprotein receptor, mainly in the liver, resulting in the reduction of blood cholesterol and low-density lipoprotein cholesterol levels, thus playing a role in the prevention and treatment of atherosclerosis and coronary heart disease (source: Baidu Encyclopedia).

Sulfasalazine (sulfasalazine)

Sulfasalazine (sulfanilamide) is an antibacterial agent. It is a sulfonamide which is not easily absorbed by oral administration. The absorbed part is decomposed into 5-aminosalicylic acid and sulfapyridine under the action of intestinal microorganisms. 5-aminosalicylic acid stays in the intestinal wall tissue for a long time after complexing with the intestinal wall connective tissue, which plays an antibacterial, anti-inflammatory and immunosuppressive role, such as reducing Escherichia coli and Clostridium, and inhibiting the synthesis of prostaglandin and leukotrienes (source: Baidu Encyclopedia).

Digoxin

Digoxin is an intermediate cardiac glycoside, which is white crystal or crystalline powder. Odorless; It tastes bitter. In the treatment, the effect on the heart is positive inotropic effect, slowing down the heart rate and inhibiting heart conduction. It is suitable for congestive heart failure with low output, atrial fibrillation, atrial flutter and paroxysmal supraventricular tachycardia.

Bacteria in the intestine can regulate the availability and efficacy of therapeutic drugs. However, the potential mechanism of the interaction between drugs and bacteria is the chemical transformation or biological transformation of drugs by microorganisms.

A team of scientists from Heidelberg, Germany and Cambridge, England just published in Nature, and successfully studied the consumption of 15 drugs with different structures by 25 representative intestinal bacterial strains. 70 kinds of bacteria and drug interactions were revealed, 29 of which were not reported before. More than half of the new interactions can be attributed to biological accumulation.

This biological accumulation of intestinal bacteria may be a common mechanism to change drug availability and bacterial metabolism, which may have little effect on individuals.Biota composition, pharmacokinetics, side effects and drug reactionsHave an impact.

Drug non-metabolic accumulation

For a more detailed investigationDrugs and bacteriaA systematic map of the interaction between scientists.Two analytical methodsNuclear magnetic resonance (NMR) and liquid chromatography-mass spectrometry (LC-MS) were used to systematically analyze 1.Five human targeted drugs and 25 human intestinal bacteria.Interaction between Bifidobacterium longum, Escherichia coli and other subspecies or strains of the same species of Bacteroides Homogeneous. Select bacterial species to cover those representing healthy microbial communities.Extensive phylogeny and metabolic diversity. In terms of drugs, 12 kinds of oral small molecular drugs (molecular weight less than 500 Da) were selected, which can be quantified based on ultra-high performance liquid chromatography combined with ultraviolet detection (UPLC-UV) toCross different chemical, indication areas and side effects.

Bacterial-drug interaction network. Left network: biotransformation or accumulation of drugs by intestinal bacteria. Right network: the influence of drugs detected in at least two independent screening on the growth of intestinal bacteria (Student’s t test, α = 0.05). The full names of bacteria not mentioned in this paper are as follows: Bacteroides fragilis, Bacteroides vulgaris and Bifidobacterium animalis subspecies. Lactobacillus BI-07, Coprococcus come, Clostridium, Clostridium, lactobacillus paracasei, Ruminococcus gnavus.

Among the 29 newly discovered interactions (14 drugs and 4 drugs), as many as 17 species are bioaccumulation events.; That is to say,Drugs are stored by bacteria without changing it.. the rest Twelve interactions (8 drugs and 5 drugs) may represent biotransformation events.. Two of the five drugs: levamisole and ezetimibe, were indeedOther intestinal bacterial chemistry coursesDecorate.

Among bioaccumulative drugs,Antidepressant Duloxetine/Cymbalta(duloxetine) andRosiglitazone, a hypoglycemic drug.beThe only bioaccumulative drugEach species accumulates in many different species.

However, biodegradation and bioaccumulationInteraction is not mutually exclusive.. Montelukast (for asthma) and roflumilast (for chronic obstructive pulmonary disease)Bioaccumulation by some bacteria and degradation by other bacteria.. In terms of bacteria, all strains except Fusobacterium nucleatum showed two types of interactions. In addition to the interaction with widely interacting control drugs sulfasalazine and metronidazole, the same strains of Bifidobacterium (B. uniformis) and Escherichia coli (E. coli) were found to be in the same strain.There is no overlap in interaction.. Because individuals usually have different strains, bioaccumulation is interactive.The prevalence rate may be higher than the research results..

Levamisole (levamisole)Levamisole is a broad-spectrum anthelmintic drug, which is mainly used to repel ascaris and hookworms. It can improve the resistance of patients to bacterial and viral infections. At present, it is used as adjuvant therapy for lung cancer and breast cancer after surgery or acute leukemia and malignant lymphoma after chemotherapy.

Ezetimibe (ezetimibe)Selective cholesterol absorption inhibitor is a lipid-lowering drug.

Duloxetine/Simpatine, mainly used to treat depression. It mainly regulates the balance of neurochemicals in brain tonic by inhibiting the recovery of serotonin and norepinephrine.

Rosiglitazone (rosiglitazone)Rosiglitazone and pioglitazone are thiazolidinedione hypoglycemic agents commonly used in clinical treatment in China at present. This product is an insulin sensitizer. By increasing the sensitivity of skeletal muscle, liver and adipose tissue to insulin and improving the utilization of glucose by cells, it can significantly reduce fasting blood glucose, insulin and C-peptide levels, and also reduce postprandial blood glucose and insulin. However, patients are required to have a certain ability to secrete insulin.

The World Health Organization’s International Agency for Research on Cancer listed rosiglitazone in the list of three carcinogens.

Due to manyHuman targeted drugs have been proved to affect the growth of intestinal bacteria.. The study examined the identifiedCan bacterial-drug interactions also lead to growth changes?. Although more than 30 major inhibitory drug-bacteria interactions have been detected, only.The three kinds of interactions involve both modifying growth and changing drug concentration.(excluding control drugs sulfasalazine and metronidazole). Therefore,The interaction between bacteria-drugs and drugs-bacteria seems to be largely independent..

In order to confirm the bioaccumulation of the interaction between bacteria and drugs, the study usedThe other two analytical methods are nuclear magnetic resonance (NMR) spectroscopy and liquid chromatography-mass spectrometry (LC-MS).. As a case in point,Duloxetine, a widely used antidepressant, was found to be bioaccumulated by eight kinds of bacteria. Nuclear magnetic resonance spectroscopy can clearly detect duloxetine and confirm it.Four selected strains(Streptococcus salivarius, Bacteroides simplex, Escherichia coli IAI1 and Escherichia coli ED1a) were removed from the culture medium without biotransformation. LC-MS analysis in compound GMM medium also confirmed it.Clostridium saccharides and Escherichia coliBioaccumulation of IAI1 in the concentration range of 30 to 70.

Nuclear magnetic resonance analysis showed that Streptococcus salivarius was sensitive to duloxetine.biotic pyramid

Biological accumulation affects cell metabolism.

Although biotransformation can be attributed tometabolic enzymeHowever, drug bioaccumulation is in mechanism.It’s even harder to imagine. In order to study the molecular basis of drug bioaccumulation by intestinal bacteria, scientists set out to determine the concentration of duloxetine in bioaccumulative strains.Protein target. Firstly, an acetylized, "clickable" molecular version was constructed and used as bait.　　

Click chemistry and thermal protein group analysis (TPP) showed that protein binding was a contributing factor to duloxetine bioaccumulation. This raises the question of whyThese two strains of E.coli showed different degrees of duloxetine bioaccumulation in GMM.. Two strains of Escherichia coli were compared in two different TPP assays, in which drugs were added to lysed cells or whole cells. Although TPP in cell lysate can find protein which is stable or unstable due to the direct binding of duloxetine, intact cell TPP can also capture the changes of cell reaction (changes of protein interaction and activity) in vivo.

Note: Click Chemistry, which aims to create various functional substances (candidate drug compounds, biological probes, soft materials, etc.), is a very widely used reaction. As a basic technology, it is characterized by high chemical selectivity, high yield, fast reaction speed and easy formation of strong chemical bonds.

In a complete cell assay,biotic pyramidThe IAI1 strain is more abundant than the abiotic ED1a strain.Has almost twice as muchDrug-reactive protein, and thermostable.The overall change is stronger. Consistent with the fact that duloxetine changed cell physiology more significantly in bioaccumulative strains, IAI1 strain also showed it in differentially expressed protein.A more obvious reaction.

In contrast, these two strains show very similar characteristics in TPP based on lysate, in which the lack of cell envelope enables drugs to reach all intracellular protein. Therefore,The strain specificity of bioaccumulation is probably due to the difference of absorption and consumption systems, which is similar to the transporter-dependent specificity observed in drug-drug interaction..

The combination of duloxetine and metabolic enzymes shows that the biological accumulatorMetabolism has changed.. To test this, two complementary metabolomics platforms were used-Flow injection analysis mass spectrometry (FIA-MS) and hydrophilic interaction chromatography combined with tandem mass spectrometry (HILIC-MS/MS).Methods: To analyze the effects of duloxetine treatment on six bacterial strains (four bioaccumulative and two non-bioaccumulative)Small molecule secretion.

Among the four strains, there are three bioaccumulative types (C. saccharolyticum, Lactobacillus plantarum and E.coli IAI1) and one non-bioaccumulative type (Lactococcus lactis), which show their characteristics after drug treatment in GMM.A significant shift in metabonomic patterns. The drug-induced changes in the ectometabolism group are equivalent to the interspecific differences.　

In addition, the drug reaction was concentration-dependent, and no effect was observed on the non-bioaccumulated roflumilast. The concentration-dependent reaction to duloxetine was further verified by a subset of 71 metabolites, in which the chemical characteristics were presumed to be assigned-two metabolites confirmed by chemical standards-using tandem mass spectrometry. Clostridium saccharolyticum also showed a strong metabolic response to duloxetine when detected in nutrient-deficient PBS buffer.

Anyway,Protein omics and metabonomics data show that duloxetine binds to abundant metabolic enzymes to support its intracellular storage..

three

Biological accumulation leads to cross-feeding

Metabolic interaction is the basis of shaping the composition of intestinal microbial community.. So, will the metabolic changes related to biological accumulation affect the community composition?

In order to solve this problem, the researchers assembled five stable communities of intestinal bacterial species (Bacteroides thetaiotaomicron, Eubacterium rectale, Lactobacillus gasseri, Ruminococcus bolts, Streptococcus salivarius) with and without duloxetine. One of these five species is S. salivarius, and the other is directly inhibited by E. rectale. These five species were co-inoculated in GMM and then transferred to fresh medium every 48 hours.　

The existence of duloxetine significantly changed the community composition.Compared with the situation without drugs,The abundance of E.coli in rectum has increased by more than 100 times.. This is noteworthy because of the five species used by researchers,Rectal Escherichia coli is the most sensitive to duloxetine.. Consistent with Streptococcus salivarius as a bioaccumulator, duloxetine is exhausted in the supernatant of the community. Although decreasing the concentration of duloxetine can protect the rectal Escherichia coli in the community, it takes longer to reproduce in the presence of duloxetine.

Duloxetine bioaccumulation changes community assembly and host response.

supposesalivaChanges in the secretion of duloxetine metabolites by Streptococcus liquidus can promote rectal Escherichia coli.. Supporting this, the used culture medium from S. salivarius grown in the presence of drugs improved the growth of E. rectale. Non-targeted metabolomics data from FIA-MS and HILIC-MS/MS further support the cross-feeding hypothesis.　

Therefore, it was found that several metabolites were accumulated in the culture process of S. salivarius and then exhausted in the growth process of E. rectale. Among them, five metabolites are presumed to be annotated,Linolenic acid and cholic acidIt is confirmed by using analytical standards (methods). The changes of nucleotide-related metabolites (such as uridine -5′- diphosphate) are consistent with the critical nature of protein and metabolites influenced by duloxetine and E. rectale. Therefore,Human targeted drugs can regulate intestinal microbial community, not only by direct inhibition, but also by creating cross-feeding opportunities..

Bioaccumulation affects host response.

Then, the researchers used Caenorhabditis elegans as a model system to study the effect of duloxetine bioaccumulation on host response. Duloxetine as a kind ofSerotonin-norepinephrine reuptake inhibitorAnd regulate the behavior (muscle movement) of Caenorhabditis elegans in a concentration-dependent manner.　

In the presence of bioaccumulative species (Escherichia coli IAI1) as part of the growth medium of Caenorhabditis elegans, animal movements were examined as behavioral readings. As a closely related control, the researchers used E.coli ED1a strain which did not bioaccumulate in complex growth medium. In fact,Only strain IAI1, a bioaccumulation strain of duloxetine, weakened the influence of duloxetine on the host.Although the intestine of C. elegans is colonized by facultative anaerobic bacteria and obligate aerobic bacteria, it is likely to be aerobic, but the results are very consistent with the biological accumulation observed in anaerobic culture experiments.

Therefore, it is necessary to further study the microbiome-duloxetine-host interaction in other model systems or clinical environments.

Total knot

The results reveal that the therapeutic effect of host-targeted drugs can be achieved by intestinal bacteria in two ways.biotic pyramidTo adjust:

First, the main effect produced by reducing the availability of drugs;

Second, the secondary effect produced by changing the secretion of metabolites.　

The latter willLead to changes in community composition.This is related to some drugsassistantAction and even the mode of action.. For the case drug duloxetine in this study, the intestinal bacterial interaction is indeed related to the side effects such as weight gain and its mode of action.

editorial comment/note

Bacteria in the intestine can affect the activity or efficacy of drugs. Recent studies show that this effect is not only biotransformation (changing the composition of drugs or metabolizing them into new substances),Bioaccumulation of drugs stored in cells by specific bacteriaIt may be another important influence (accounting for more than half of the newly discovered role). By accumulating drugs in cells, it willGreatly changes the efficacy of many dose-dependent drugs.(such as the antidepressant duloxetine under study), and it absorbs the bacteria that have accumulated drugs.Metabolism will change., which in turn willaffectInteracting with itOther bacteriaAnd finally change the composition of the flora.

References:

Klünemann M, Andrejev S, Blasche S, Mateus A, Phapale P, Devendran S, Vappiani J, Simon B, Scott TA, Kafkia E, Konstantinidis D, Zirngibl K, Mastrorilli E, Banzhaf M, Mackmull MT, H?velmann F, Nesme L, Brochado AR, Maier L, Bock T, Periwal V, Kumar M, Kim Y, Tramontano M, Schultz C, Beck M, Hennig J, Zimmermann M, Sévin DC, Cabreiro F, Savitski MM, Bork P, Typas A, Patil KR. Bioaccumulation of therapeutic drugs by human gut bacteria. Nature. 2021 Sep 8. doi: 10.1038/s41586-021-03891-8. Epub ahead of print. PMID: 34497420.

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Market confidence continues to strengthen, and the role of the main channel of the capital market is increasingly prominent.

　　Since the beginning of the year, the A-share M&A market has been active. According to the statistics of straight flush iFinD, as of February 9, 236 listed companies have issued announcements related to mergers and acquisitions during the year, subject to the date of the first announcement.

　　Many insiders said that the optimization of merger and reorganization policies and confidence in economic recovery are the main reasons for the active market. Under the background of the full implementation of the stock issuance and registration system, this year’s M&A market is expected to be more active, which will play a greater role in improving the efficiency of resource allocation, stimulating the vitality of market players and improving the quality of listed companies.

　　Market confidence continues to strengthen.

　　In recent years, China’s M&A market as a whole is improving steadily, and its vitality and influence are increasing day by day. In particular, A-share listed companies have gradually become the "main force" of enterprise M&A, and the role of the main channel of capital market M&A has become increasingly prominent.

　　Tian Lihui, dean of the Institute of Financial Development of Nankai University, believes that when the securities market is at a low valuation, the stock price of an enterprise may be lower than its intrinsic value. During this period, the low cost of mergers and acquisitions will accelerate the market activity. At the same time, the expectation of economic recovery will often drive the stock market to rise, thus increasing the possibility of mergers and acquisitions. In addition, in the past two years, the market-oriented reform of the basic system of M&A and restructuring has been deepening, which has also attracted more listed companies to enhance their competitiveness through M&A and restructuring.

　　Chen Li, director of Chuancai Securities Research Institute, said that the promotion of listed companies’ willingness to merge and reorganize mainly comes from the continuous optimization and improvement of policies in recent years. The regulatory authorities have continuously guided small and medium-sized enterprises to connect with the capital market through mergers and acquisitions through various measures, and encouraged listed companies with needs, abilities and willingness to merge and reorganize.

　　In October 2020, the State Council issued the "Opinions on Further Improving the Quality of Listed Companies", proposing to give full play to the role of the capital market as the main channel for mergers and acquisitions, and encourage listed companies to revitalize their stocks, improve quality and efficiency, and transform and develop; In November last year, the CSRC issued the "Three-year Action Plan for Promoting the Quality Improvement of Listed Companies (2022— 2025) proposes to continuously optimize the capital market financing system, improve the supervision mechanism of mergers and acquisitions, and better promote the integration of industrial chain and supply chain.

　　With the optimization and adjustment of epidemic prevention and control measures and the continuous implementation of a package of policies and measures to stabilize the economy, China’s economy is expected to rebound. Market analysts believe that economic recovery will enhance enterprises’ good expectations for future development, and increasing confidence will promote more enterprises to accelerate the pace of resource integration.

　　Help industrial transformation and upgrading

　　People in the industry generally believe that after the full implementation of the stock issuance and registration system, the effect of survival of the fittest will be accelerated, and the demand for the integration of technical capabilities and development of listed companies will increase accordingly. With the functions of clearing bad assets, eliminating excess capacity and injecting high-quality assets, mergers and acquisitions are expected to become a "booster" for upgrading China’s industrial structure.

　　From the industries of listed companies that announced the merger and reorganization this year, there are many industries such as communication, electronic equipment, mechanical equipment, medicine and biology. Zhou Maohua, a macro researcher in the financial market department of China Everbright Bank, believes that the valuation of the above industries is at a low level, which is conducive to the implementation of mergers and acquisitions, and the industry has a high degree of prosperity. The market is generally optimistic about its development prospects.

　　"With the full implementation of the stock issuance registration system, mergers and acquisitions of new economic enterprises will become increasingly active." Wang Xuesong, president of Zhongguancun Dahe M&A Research Institute, believes that listed companies in the new economy are engines of high-quality economic development and practitioners of self-reliance in science and technology, and M&A is an important way for listed companies in the new economy to develop. New economic enterprises can use mergers and acquisitions to acquire core development factors such as new technologies, new products and high-tech talents.

　　AARON Li, deputy general manager of Shenzhen Stock Exchange, said that in recent years, the characteristics of M&A and restructuring industries and entities have become more distinct, and emerging industries have used restructuring transactions to achieve integration and agglomeration, and their activity has gradually increased.

　　"With the implementation of the comprehensive registration system, mergers and acquisitions will be more market-oriented and convenient. Marketization means that more enterprises will accelerate their development through mergers and acquisitions under the background of relatively low stock market valuation; Facilitation means that enterprises can carry out mergers and acquisitions more quickly and efficiently. " Tian Lihui said.

　　Chen Li expects that the market activity of M&A and restructuring will be further enhanced. On the one hand, with the launch of the comprehensive registration system, the pace of listing of enterprises has accelerated, and the supply of high-quality M&A targets is expected to increase, which will promote the market activity of M&A and restructuring; On the other hand, since the beginning of this year, enterprises are expected to improve and their willingness to invest has increased. Under the circumstance of great downward pressure on the economy last year, industry competition intensified, and enterprises made up their shortcomings through mergers and acquisitions to enhance their competitiveness, thus enhancing their market position.

　　Improve the quality of mergers and acquisitions

　　At present, China’s economy is in a critical stage of stabilization and recovery, structural adjustment, transformation and upgrading. It is necessary to further play the main channel function of capital market mergers and acquisitions to help high-quality economic development. At the same time, creating an efficient, standardized and market-oriented M&A market is also an inevitable requirement for building a standardized, transparent, open, dynamic and resilient capital market.

　　AARON Li believes that there may be three major trends in the future A-share M&A market: in the short term, market trends and investment withdrawal demand will further stimulate M&A power. In the medium and long term, the merger and reorganization of listed companies will continue the role of the main channel; In addition, while learning from international experience, the future M&A market will be more suitable for the characteristics of China’s capital market and realize localization, internationalization and marketization.

　　"Giving full play to the main channel function of the capital market still requires the joint efforts of many participants such as regulatory authorities, listed companies and intermediaries." Zhou Maohua said that for listed companies, mergers and acquisitions should not deviate too much from the main business, and it is necessary to evaluate the project market risks and make decisions according to their actual financial situation, and avoid blind investment and disorderly expansion; For intermediaries, they should take a good look at the role of gatekeepers, be diligent and conscientious, and press the pause button in time for projects that do not meet the requirements and have doubts; For the regulatory authorities, it is necessary to adhere to the direction of marketization and rule of law, and continue to promote and improve the relevant rules of mergers and acquisitions.

　　Strengthening supervision is still an important guarantee for the long-term healthy development of the M&A market. The CSRC recently reported the handling of cases last year, pointing out that major events such as mergers and acquisitions and changes in actual controllers are still high-incidence areas of insider trading. In this regard, the insiders suggest that the regulatory authorities should pay attention to the compliance review of M&A assets, strictly supervise the "three highs" M&A and "flickering" restructuring, resolutely curb the phenomenon of "shell speculation", and severely crack down on illegal activities such as using M&A and restructuring to occupy funds and transfer interests.

　　"To improve the quality of mergers and acquisitions, it is always necessary to protect the interests of investors, promote the simplification and optimization of mergers and acquisitions procedures, and promote market mergers and acquisitions with synergistic effects." Tian Lihui said that it is necessary to prevent administrative or performance-based mergers and acquisitions, prevent accounting or profit transfer, and at the same time improve the quality of mergers and acquisitions as soon as possible, so that mergers and acquisitions can truly realize the marketization and specialization of the whole process. (Economic Daily reporter Ma Chunyang)

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Liu Yan first exposed the inside story of breaking up with her ex-boyfriend： not red and unwilling to delay each other.

Ada revealed the inside story of breaking up with her ex-boyfriend

&emsp; &emsp;1905 movie network news Ada and Huang Cansheng, a member of the Korean Men’s Team 2PM, exposed the rumor of love when they participated in a reality show, which made many otaku "cry dizzy" on the rooftop. However, recently, Ada took the initiative to reveal the inside story of breaking up with her ex-boyfriend and burst into tears several times. It turned out that when Ada was recording the program, the experience of a North drift actress at the scene resonated with her. Ada couldn’t help but recall his famous past. He made his debut in the draft at the age of 19, but after ten years’ hard work, he didn’t make it to the top until he was 30. At the age of 29, when her career prospects were confused, she took the initiative to break up with her boyfriend who had been in love for many years, on the grounds that she didn’t want to delay each other any more.

&emsp; &emsp; It is said that Ada burst into tears several times at the recording site, which shows that her ex-boyfriend had a great influence on her. However, considering Ada’s reason for breaking up, "I don’t want to delay my boyfriend any more", I suddenly have the illusion of becoming a woman. This reason for breaking up was ridiculed by netizens as "overbearing and willful."

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Life is guaranteed, life is guarded, and go all out for earthquake relief.

CCTV News:To pay attention to the news of Xizang’s earthquake rescue with a magnitude of 6.8. It entered the fourth day after the earthquake on January 10, and now it has been about 85 hours since the earthquake. At present, the earthquake relief work is at a critical stage. How do people in the earthquake-stricken areas live and eat? Can everyone’s basic life be guaranteed? Let’s pay attention together.

On the afternoon of January 10th, the reporter saw at a transitional resettlement site in Senga Village, Changsuo Township, which suffered the most, that the on-site staff were busy building container houses, and all the buildings could be completed as soon as January 11th, so as to help the local affected people improve their living conditions to the greatest extent.

According to the reporter’s understanding at the scene, the construction process of the container house here is more difficult than that of the movable board house, because the construction personnel at the scene need to move these boards to the scene by manual handling. In addition, the container house adopts reinforced steel structure, which is very strong and has better wind and earthquake resistance, and can withstand the highest earthquake of magnitude 8.0 and strong wind of magnitude 12.

In Gaguo Village, Cuoguo Township, 18 folding container board houses will be completed on January 10th.

It is understood that a container board room is about 18 square meters, and four high and low beds can accommodate eight people. At the same time, each container board room is equipped with electric heaters, electric blankets, sheets and bedding, and water and electricity are fully equipped.

In addition to prefabricated houses, Gaguo Village is currently building a smart water supply platform for 5,000 people to use water at the same time, which can produce over 1,000 tons of standard tap water every day.

The earthquake zone is full of busy figures, some people are busy building board houses, and others are busy distributing all kinds of living materials. At a tent food point in Jiding Village, Cuoguo Township, the reporter saw that many volunteers were busy making love to the affected people at lunch time.

After several hours of careful preparation, a big barrel of delicious mutton stew is ready. A bowl of braised dishes and a small piece of cake, the children basked in the sun and ate a warm lunch.

85 hours after the earthquake in Dingri County, Xizang. Life is guarded.

After the earthquake, various medical rescue teams quickly assembled and arrived at the earthquake zone at the first time, and fully carried out the treatment of the wounded from on-site disposal to transshipment treatment. Medical treatment is gradually shifting from emergency treatment to standardized treatment.

The reporter learned in Dingri County People’s Hospital that since the earthquake, several types of wounded people treated in the county people’s hospital are mainly trauma. From the day of the earthquake on the 7 th to now, hundreds of wounded people have been treated here. Another job of the county people’s hospital is the transport of critically ill patients. There are more than 40 ambulances in the county people’s hospital in a state of being on standby for transport at any time 24 hours a day. At present, the main work of the county people’s hospital has shifted from first-class treatment to standardized treatment, and doctors will also go deep into the front line of the disaster area to screen and treat more concealed diseases.

Over the past few days, under the guidance of the National Health and Wellness Commission and the National Bureau of Disease Control and Prevention, the Health and Wellness Commission of Xizang Autonomous Region has quickly launched medical emergency response and established a three-level rescue system at village, county, city and district levels. At present, medical treatment experts at all levels consult all the wounded one by one in Shigatse City, formulate treatment plans with "one person, one policy", and organize national experts to conduct online consultations.

Gadan Village, Changsuo Township, Dingri County, is one of the areas seriously affected by this disaster, where 62 households with 329 affected people were resettled. The reporter from the General Station recorded a night patrol of the National Emergency Medical Rescue Team.

The 77-year-old villager told us that when the earthquake happened, her neighbor’s cow was crushed under the rubble, and she accidentally fell and sprained to help pull it out.

At 8: 30 that evening, another batch of patients transferred from Dingri County were sent to Shigatse People’s Hospital.

In recent days, fracture patients account for a considerable proportion of patients transferred to Shigatse People’s Hospital. Orthopedics doctors rush back and forth from the clinic to the inpatient ward, making more than 100 trips every day.

Gesandoji, a villager from Changsuo Township, Dingri County, Shigatse City, Xizang Autonomous Region, said: "I was injured in the earthquake and my leg was broken. The ambulance sent me to the hospital for treatment in time, and now my body is much better."

Ge Sang, the family member of the wounded, said: "The doctor’s treatment is very timely, the hospital conditions are also very good, and the injury is continuing to improve."

On the morning of the 9th, when the medical team visited Gabu Village, it was found that the villager Pubugsang was injured in his right eye due to aftershocks. In the afternoon, as the rescue helicopter landed slowly, Pubugsang was safely transported to the General Hospital of Xizang Military Region.

Lausanne, an ophthalmologist at the General Hospital of Xizang Military Region, said: "The patient’s right eye was injured by a heavy object in the earthquake, which caused pain, bleeding and severe vision loss. Our initial diagnosis was right eye optic nerve contusion, right eye traumatic cataract and right eye lens dislocation. "

At present, Pubugsang is receiving treatment. After improving various preoperative examinations, he will be given cataract extraction and intraocular lens implantation.　

They went all out 85 hours after the earthquake in Dingri County, Xizang.

After the earthquake of magnitude 6.8 in Dingri County, Shigatse, Tibet, the central and local governments responded quickly, and people’s soldiers and other rescue forces quickly dispatched to go all out for earthquake relief. Next, let’s review the rescue moments together.

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Kim Jong-un presided over the disaster relief work in the typhoon-stricken area and inspected the disaster situation in the disaster area.

　　Xinhua News Agency, Pyongyang, September 6 (Reporter Hong Kerun, Jiang Yaping) According to Korean Central News Agency’s report on the 6th, Kim Jong-un, chairman of the Workers’ Party of Korea, chairman of the State Council and supreme commander of the armed forces, presided over an enlarged meeting of the Government Affairs Bureau of the CPC Central Committee in the typhoon-stricken area on the 5th to deploy disaster relief work in South Hamgyong Province and North Hamgyong Province, and to investigate the disaster situation in the disaster-stricken area.

　　The report said that North Korea was hit by Typhoon Mesak on the 3rd, and the South Hamgyong Road and North Hamgyong Road in the northeast of North Korea suffered major disasters. More than 1,000 houses were destroyed in each road, and many public buildings and farmland were flooded.

　　The report also said that the enlarged meeting of the Political Affairs Bureau of the CPC Central Committee discussed the post-disaster reconstruction work of South Hamgyong Province and North Hamgyong Province, and made decisions on specific matters such as building engineering forces and ensuring material transportation.

　　On the same day, Kim Jong-un also visited some disaster-stricken areas in South Hamgyong Province. He pointed out that most areas along the coast have weak security measures, and demanded that coastal dampproof dikes and harbor breakwaters be built according to standards. Kim Jong-un also learned about the growth of crops affected by the disaster, and stressed the need to actively take agricultural technical countermeasures to avoid the reduction of output as much as possible.

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July scientific gossip list： O blood attracts mosquitoes most？

People’s Daily Online, Beijing, August 1st (Zhao Zhuqing) "O-type blood attracts mosquitoes especially", "Too much beer will lead to a beer belly" and "Eating out-of-season fruits and vegetables is harmful to health" … With the arrival of midsummer, all kinds of "legends" about summer began to be "hot" on the Internet. A few days ago, the Beijing Science and Technology Journalists Editors Association and the Beijing regional website jointly released the "July Science Rumors List" to expose the true face of these rumors one by one.

1. Is the "beer belly" really drunk by drinking beer?

Myth: Many people say that beer belly is definitely related to beer, because beer is "liquid bread", and drinking too much will cause beer belly.

Truth: Beer belly is a figurative term. The real cause is unreasonable eating habits, and beer with the same weight is far less calorie-rich than bread.

The real beer belly is a lot of fat accumulated on the belly, and the accumulation of fat comes from excessive energy. Even female comrades who don’t drink beer and accumulate more body fat will have a very fat abdomen.

Li Hong, a professor-level senior engineer in the Brewing Engineering Development Department of China Food Fermentation Industry Research Institute, said: "The excess energy comes from two aspects. The first is too much energy intake, and the second is too little energy consumption. After excess energy exists in the form of fat, it is easy to accumulate in the abdomen. So, does it have anything to do with beer? It should be said that there is no direct and inevitable relationship, but what is really relevant is the way and lifestyle of consuming food. "

A study by the German Federal Institute of Nutrition Medicine shows that "beer belly" is related to male genes, just like female obesity starts from the buttocks, and most of male fat is stored in the abdomen. The researchers found that beer drinkers are not more likely to have a beer belly or even obesity than those who don’t drink beer. Although beer is not a diet drink, it is not the cause of overweight. If factors such as exercise and education are excluded, people who often drink beer will not have thicker waistlines and heavier weights than those who don’t drink or rarely drink.

2. Type O blood attracts mosquitoes most?

Myth: When summer comes, mosquito bites make many people miserable. Many rumors say that type O blood is sweet and fragrant, so type O blood is especially attractive to mosquitoes.

Truth: Mosquitoes mainly rely on carbon dioxide, heat, volatile chemicals and other factors to detect and locate targets. It can distinguish some molecules produced by human cell activities. As long as you are breathing, sweating or emitting heat, your temperature, the water vapor and carbon dioxide you release, and the chemicals in your sweat, such as acetone, octenol and lactic acid, are tempting mosquitoes to follow the trail to find you.

So is there any relationship between blood type and mosquitoes? Scientists and media from all over the world have done a lot of experiments, and the current conclusion proves that there is no direct relationship.

As for the saying that "blood is sweeter than mosquitoes", according to the current research conclusions, there is no direct connection between these two points. If you want to find the correlation from the blood test report, you may wish to pay attention to the routine examination of the physical examination report. There is an item called "eosinophils" in the column of blood test, and those who are higher in this item are better for mosquitoes.

3. Is there really a "watermelon injection"?

Rumor: A friend in Daxing told me that now melon farmers are spraying pesticides on watermelons, growing fast and selling money, and grafting on pumpkin seedlings, and they never eat them themselves! "Injection watermelon" is injected with banned food additives-sodium cyclamate and carmine! It may damage the liver and kidneys and affect children’s intellectual development! The watermelon pulp that has been injected is red and the juice is "rich".

Truth: In response to rumors, Shenzhen Inspection and Quarantine Bureau conducted a surprise inspection on six watermelon enterprises and processing plants in its jurisdiction, and none of them detected saccharin sodium, artificial color and mercurochrome (mercury bromide red). Some experts even conducted injection experiments, and the results showed that the color of watermelon pulp after injection was uneven, and because the pinhole was easy to be infected with bacteria, watermelon was perishable, which was not conducive to sales.

As for injecting sodium cyclamate and carmine, the reason is similar. According to botanical principles, plants can only absorb water and nutrients in living conditions, and they need to be organized by means of plant transportation system. However, the vascular bundles of melon seedlings are very small, and it is hard to imagine that they want to inject liquid. Even if the injection is successful, it must be absorbed and transformed by the plant itself to make it sweet. However, these two substances cannot be absorbed normally by the melon seedlings.

Moreover, after the injection, the pinhole on the watermelon is obvious, the juice will overflow from the pinhole, and the color of the pulp at the injection site will also deepen. These phenomena are very obvious, and it is easy for merchants to be seen through if they really do this.

No matter during the growth or after the harvest of watermelon, it is impossible to absorb the liquid substance by injecting it into the watermelon fruit. Only through vascular tissue can plants absorb water and nutrients and inject them into fruits forcibly, and the injected substances will accumulate in tiny tissues and destroy the tissue characteristics of watermelon pulp, which can never be like that in Weibo: red watermelon pulp and rich juice. This is also proved by experiments. No matter the size of the pinhole, the outer ring of the pinhole will begin to blacken after two or three hours of storage of the injected watermelon, which is easy to find. How can anyone do such a thankless thing if it is put out and no one cares about it?

4. Is it necessary to sweat in summer?

Rumor: "Practicing for 39 days in winter and three days in summer" is the spoken language of many middle-aged and elderly people’s sports, especially in the dog days, and middle-aged and elderly people who are sweating can be seen everywhere on the avenue and in the park. They said that many health reminders said: "It is only comfortable to sweat thoroughly, and the fitness effect can be achieved."

Truth: Experts remind that fitness should not blindly pursue sports pleasure, especially in the summer when sweating and consumption are high, bodybuilders should pay more attention to the degree of exercise to avoid excessive consumption and damage to some functions of people.

Sweat properly in summer, but you don’t need to exercise until you sweat profusely. In fact, it is easy to cause dehydration. At the same time, people’s body temperature rises obviously after summer exercise, and with the influence of high temperature weather, they are prone to heatstroke. Therefore, most people should avoid extreme exercise and anaerobic exercise, and it is best to use aerobic uniform exercise, and the heart rate should be controlled in a small exercise area, that is, about 120 times/minute. Middle-aged and elderly people should be slower, because if they exercise excessively in midsummer, sweating will lead to thick blood. Coupled with the hot weather, it is likely that they will not be healthy, but will lead to heart disease and cerebral infarction.

Exercise in the sun for a long time in summer will aggravate the disorder of water and salt metabolism in the body. Therefore, you should drink some light salt water or sports drinks before, during and after exercise, about 50 ~ 100 ml every half hour.

In addition, summer exercise is more suitable to choose morning or evening, and the location is chosen in a place with shade. The duration of exercise should not be too long, and it should be 30 minutes to 1 hour, which can be adjusted according to personal physique and exercise intensity.

5. Will the baby die if he eats salt?

Rumor: Recently, it was reported that "a mother listened to her neighbor’s advice and added salt to her porridge, but she didn’t expect to ruin her eight-month-old child’s life."

Truth: Salt is essential for everyone. For infants, less salt is the general principle.

One of the reasons why we need less salt is because of physiological limitations. The salt in the human body is mainly metabolized by the kidney, more than 90% enters the urine, and the rest is excreted through sweat. Because the development of infants’ kidneys is not complete, excessive salt intake is likely to increase the burden on the kidneys, lead to abnormal metabolism, and cause edema. Of course, it’s impossible to be so exaggerated to die immediately.

The main reason for the lack of salt is long-term consideration. The occurrence of hypertension is closely related to high-salt diet, and in order to reduce the salt intake of adults, we must start from controlling the taste of infants. Infant’s taste system is still in the developing process, and it is very sensitive to condiments. Too much salt may not only affect their eating habits in the long run, but also cause refusal to eat.

That is to say, it’s not "babies can’t eat salt within one year old", but following the general principle of less salt, it’s not necessary to add extra salt to babies, but also to keep your eyes open, pay attention to the formula table of complementary food, and rationally allocate baby’s recipes.

6. margarine equals trans fatty acids?

Myth: Margarine is mainly extracted from edible oils and fats, so margarine contains more oils and fats, especially trans fatty acids. Eating a lot of trans fatty acids will affect people’s memory, and for teenagers, it will affect the development of the central nervous system. Long-term excessive accumulation of trans fatty acids can also induce serious diseases such as asthma, tumor and diabetes.

Truth: The statement that "trans fatty acids have health risks" has been widely circulated. Recently, China Food Rumor Alliance and China Baked Food and Sugar Products Industry Association publicly refuted this rumor. The Food Rumor Alliance stated that raw materials of baked goods such as margarine and hydrogenated vegetable oil are not equal to trans fatty acids, and the argument that trans fatty acids cause obesity and diabetes is still inconclusive.

According to Zhu Nianlin, chairman of China Baked Food and Sugar Products Industry Association, trans fatty acids have always been regarded as "time bombs on the table", and raw materials in baked goods-margarine, hydrogenated vegetable oil, non-dairy creamer, shortening and cocoa butter substitute are often labeled as trans fatty acids, which has caused adverse effects on the industry.

Professor Cao Yanping from the College of Food Science of Beijing Technology and Business University said that with the development of technology, the trans fatty acid content in oil has dropped to a very low level. If consumers need it, they can completely remove trans fatty acids, but it will affect the taste of food.

According to Kai Zhong, deputy director of Kexin Food and Nutrition Information Exchange Center, in addition to processed foods, trans fats are widely found in natural foods such as beef, mutton, fat and milk. According to the report of China Residents’ Dietary Intake Level of Trans Fatty Acids and Its Risk Assessment by the National Food Safety Risk Assessment Center in 2013, the average daily intake of trans fats in China is 0.39 grams, and the energy supply ratio is 0.16%, which is far lower than the recommended value of the World Health Organization (less than 1%).

However, in order to control the intake of trans fatty acids, the Food Rumor Alliance suggests that consumers should pay more attention to the nutrient list on the label when buying packaged foods, and they can choose foods that do not contain trans fatty acids or have low content, especially those for infants and young children. In addition, it is necessary to control the amount of vegetable oil used in cooking, not to consume a large amount of animal fat to avoid trans fatty acids, and to avoid excessive oil temperature and repeated frying.

7. Do soy products induce breast cancer?

Myth: The disorder of breast structure caused by the absolute or relative increase of estrogen level and the decrease of progesterone level can induce lobular hyperplasia of breast, while the phytochemicals contained in soybean and bean products, such as soybean isoflavones, are known as "phytoestrogens", so bean products will aggravate mammary hyperplasia and even induce breast cancer.

Truth: Soybean isoflavone in soybean is a phytoestrogen, and many people worry that it will induce breast cancer.

In fact, phytoestrogens are different from human estrogens. It is found that phytoestrogens play a two-way role in regulating estrogen levels in women.

Studies have shown that eating soy products will not only cause breast cancer, but also reduce its risk.

8. Eating out-of-season fruits and vegetables is harmful to health?

Myth: A post about "out-of-season fruit and vegetable hazards" is widely circulated on the Internet. This post states categorically that the planting process of out-of-season fruits and vegetables is not as safe as it seems. In order to achieve high and stable yield, farmers often overuse highly toxic pesticides and ripening hormones.

Truth: Many people will say that out-of-season fruits are poisonous and inedible because they use a lot of chemicals such as pesticides. In fact, even seasonal fruits will use pesticides in the planting process. It is normal to have pesticide residues, and "existence" does not mean "exceeding the standard" or "excessive", nor does it mean that eating out-of-season fruits will do harm to the body. Moreover, as long as the general fruit is planted in a standardized way, the pesticide residue does not exceed the standard, and normal consumption will not cause harm to human health.

There is also a saying that out-of-season fruits need to be "promoted" by plant hormones, which will make people precocious. In fact, whether it is out-of-season fruit or in-season fruit, a certain amount of plant growth regulators, that is, plant hormones, are used in the modern planting process. In addition, all fruits naturally contain a certain amount of phytohormones. However, the efficacy of plant hormones is generally very low, and they are different from the molecular structure and mechanism of action of human hormones, and will not have adverse effects on the human body. It is only unfounded to worry about precocious human nature. In addition, plant hormones have strong self-limitation, and farmers will not add more in the normal planting process, otherwise it will be counterproductive.

There is another worry about out-of-season fruits, that is, they are considered to have poor nutrition.

The nutritional value of out-of-season fruits may indeed be different from that of in-season fruits. However, these differences do not mean that they are not nutritious, let alone harmful. Considering that in the cold winter, if there is no fruit to eat, human health may be more affected. From the perspective of nutrition supply, eating fruit is much better than not eating. For example, eating grapes out of season in winter is far better than "no grapes to eat".

Generally speaking, there is nothing wrong with out-of-season fruits and vegetables. Compared with winter without fruits and vegetables, out-of-season fruits are still very helpful for people to obtain and supplement nutrients, especially vitamins and minerals.

9. "Don’t eat after noon" helps to lose weight?

Myth: "Don’t eat after noon" probably means that you don’t eat after noon (from 11: 00 noon to 1: 00 pm) until dawn the next day. In the minds of many dieters, "no food after noon" is regarded as "a good way to lose weight". Some people even regard it as a "secret method of health preservation" and insist on it for many years.

Truth: If people are on an empty stomach for a long time, then the body will have some abnormal reactions-the contents of two hormones that regulate weight will deviate greatly from the normal value:

Brain-gut peptides that can increase appetite, stimulate hunger, accelerate gastric emptying and gastric acid secretion will increase rapidly; Leptin, which can reduce appetite and inhibit the synthesis of fat cells, will be greatly reduced. If so, people will not lose weight after lunch, but will gain weight more easily.

Eating the right dinner is more helpful to health than not eating it. It is best to have dinner between 5: 00 and 7: 00, and try to keep it regular; Dinner should be light, and you can eat some lean meat or eggs with short muscle fiber and easy digestion. Eat more vegetables and coarse grains.

Compared with the ancients, modern people have a large amount of activities at night, and often go to bed in the early hours of the morning. If they don’t eat dinner or even stop eating, they will lack energy, and there is gastric acid in the human stomach. If they don’t eat for a long time, it may cause gastric acid to damage the gastric mucosa, and diseases such as ulcers will appear over time. If the ulcer is not found in time, it is likely that more serious diseases such as gastrointestinal bleeding and ulcer perforation will occur.

"No food after noon" is not suitable for everyone. Only by grasping the rhythm and habits of eating carefully can we realize our pursuit of good figure under the premise of health. Eat after noon, and eat with high quality. This is the correct way to keep in good health.

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Is about to turn into a super typhoon! Typhoon ＂Du Surui＂ struck these places to be alert to extreme precipitation.

　　China Weather Network News This morning (July 24th), the No.5 typhoon "Du Surui" this year has been strengthened to a strong typhoon level, and it will become a super typhoon tonight, and it will probably land in Fujian or Guangdong as a typhoon or strong typhoon level later, which may become the strongest typhoon landing in China this year. Affected by this, Taiwan Province, Fujian, Zhejiang and other places have experienced strong winds and heavy rains, and some areas may break the precipitation record in the same period. What are the characteristics of Du Surui? What other changes have taken place in its path trend? When does it enter the core period of influence?

　　Typhoon "Du Surui" strengthened rapidly in two days, and the strongest typhoon could reach super typhoon level.

　　At 08: 00 on July 21, the No.5 typhoon "Du Surui" was generated this year, and it has been moving slowly in the east of the Philippines since then. In recent two days, "Du Surui" has strengthened rapidly, strengthening to a strong tropical storm level at 05: 00 on the 23rd, a typhoon level at 17: 00 on the 23rd, and a strong typhoon level at 24: 08.

qxtx

　　"Du Surui" is huge and the cloud system is complete. (Photo/National Satellite Meteorological Center)

　　"Typhoon ‘ Du Surui ’ It has the characteristics of strong strength, strong wind and rain and wide influence. " According to Zhang Juan, a meteorologist of China Weather Network, from the cloud image, the typhoon eye of Du Surui is clear and complete at present; The southwest monsoon on the south side continuously gives water vapor and energy support, and the wispy high-level outflow cloud system can be clearly seen on the east side, which means that the pumping effect of high-altitude outflow is also strong; Coupled with the current high sea temperature conditions, these are conducive to the enhancement of typhoon intensity. It is estimated that the peak intensity of Du Surui can reach the super typhoon level.

　　There are still variables in the trend of Du Surui’s high probability landing in Fujian or Guangdong coastal areas.

　　At 14: 00 this afternoon, the center of Typhoon Du Surui was about 900 kilometers southeast of Taiwan Province’s Eguanbi. It is estimated that it will move to the northwest at a speed of 10-15 kilometers per hour, and its intensity will continue to strengthen. The strongest typhoon level can reach (the strongest wind force near the center is 16-17), and it will gradually approach the southern coast of Taiwan Province Island, possibly passing through or landing on the southwest coast of Taiwan Province, then approaching the coast of Fujian, landing on the coast of Fujian in the morning of the 28th, and moving to the north-west direction after landing.

　　Zhang Juan reminded that there are still variables in the path trend of "Du Surui", and the specific direction depends mainly on the "face" of the subtropical high. If the subtropical high is stronger, the weight of the typhoon going west will increase, and there is the possibility of landing in eastern Guangdong; If the subtropical high weakens, the typhoon track will be northward, and the possibility of passing by or landing in Taiwan Province will increase. "Du Surui" may avoid Luzon Island in the Philippines and Taiwan Province Island in China, and become a first-hand typhoon landing in Fujian or Guangdong, which will have a greater impact on the wind and rain, and the change of landing location will affect the change of the core rainfall area. The public should pay close attention to the typhoon trends and trends and make preparations for typhoon defense in advance.

　　Taiwan Province, Fujian, Zhejiang and other places with strong winds and heavy rains may break the precipitation record in the same period.

　　Under the influence of Du Surui, it is estimated that there will be 9-11 winds and 12-14 gusts in bashi channel, the southeast of Taiwan Province, the Taiwan Province Strait, the southern coast of Taiwan Province Island and the south-central coast of Fujian from 24th to 29th. The winds in the nearby sea or areas where Du Surui Center passes are 12-16, and the gusts can reach 17 or above.

　　"The impact of typhoon on China’s rainfall will gradually appear from tomorrow." Zhang Juan said that from the night of the 25th, the rainfall in southeastern Taiwan Province will gradually increase; From 27th to 29th, it is the main period affected by typhoon. Among them, there will be heavy rain or even heavy rain in most parts of Taiwan Province on the 27th, and there may be heavy rain or heavy rain in Fujian and southern Zhejiang on the 28th, and some areas may break the precipitation record in the same period.

qxtx

　　Typhoon "Du Surui" struck hard. Keep this scientific defense guide.

　　Typhoon Du Surui’s peak intensity can reach super typhoon. Whether it lands in Taiwan Province, Fujian or Guangdong, it will bring strong wind and rain, which will seriously affect the daily life of local people. So, what preparations do residents need to make before the typhoon comes? How to avoid danger when a typhoon comes?

　　Before the typhoon comes, residents should listen, watch or check the typhoon warning information in time to understand the government’s typhoon prevention measures; Then close the doors and windows, and turn off computers, televisions and other electronic equipment; Reserve food and water, and prepare emergency items such as mobile power supply and flashlight; Check whether the circuit, fire, gas and other facilities are safe; Residents living in all kinds of dilapidated houses, factories and sheds should be moved to safety in time; If you are already in a solid house, you can stick a "meter" pattern on the window glass with adhesive tape to prevent the window glass from breaking.

　　When the typhoon comes, you should continue to pay attention to the dynamic information of the typhoon. It is best not to go out. If you are outside, don’t take shelter from the wind and rain near temporary buildings, billboards, iron towers and trees. If you drive, you should immediately drive to the underground parking lot or shelter; If you are in a tent, you should immediately put away your tent and take shelter from the wind in a solid house; If you are on the water, you should immediately go ashore to take shelter from the wind and rain. (Text/Song Huacheng Design/Luo Jiaxue Data Support/Zhang Juan)

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In-depth study and understanding of General Secretary Supreme Leader’s new ideas, new viewpoints and new conclusions on cultural construction (in-depth study and implementation of Supreme Leader’s Soc

　　synopsis

　　Culture is an important force for national survival and development. To shoulder the new cultural mission and build the modern civilization of the Chinese nation, we must thoroughly study and understand the new ideas, new viewpoints and new conclusions of the Supreme Leader General Secretary on cultural construction, and implement them in all aspects of the whole process of cultural construction.

　　Since the 18th National Congress of the Communist Party of China, the CPC Central Committee with the Supreme Leader as the core has put cultural construction in an important position in the overall work in the practice of leading the party and the people to promote the governance of the country, continuously deepened the understanding of the regularity of cultural construction, and put forward a series of new ideas, new viewpoints and new conclusions, which has promoted the historical achievements and changes in China’s cultural construction in radical reform and innovation, and provided strong positive energy for upholding and developing Socialism with Chinese characteristics in the new era and creating a new situation in the development of the cause of the party and the country. General Secretary of the Supreme Leader pointed out at the symposium on cultural inheritance and development: "It is our new cultural mission in the new era to continue to promote cultural prosperity, build a cultural power and build a modern civilization of the Chinese nation at a new starting point." To shoulder the new cultural mission and build the modern civilization of the Chinese nation, we must thoroughly study and understand the new ideas, new viewpoints and new conclusions of the Supreme Leader General Secretary on cultural construction, and implement them in all aspects of the whole process of cultural construction. Among them, we must grasp the following important aspects in depth.

　　Adhere to "two combinations" and consolidate cultural subjectivity

　　General Secretary of the Supreme Leader pointed out: "It is the only way to open up and develop Socialism with Chinese characteristics on the profound foundation of Chinese civilization for more than 5,000 years, and to combine the basic principles of Marxism with the concrete reality of China and the excellent traditional Chinese culture. This is our regular understanding in exploring the road to Socialism with Chinese characteristics and the greatest magic weapon for our success. " "Insist on combining the basic principles of Marxism with the concrete reality of China and the excellent traditional Chinese culture" is a major conclusion put forward by the Supreme Leader General Secretary in his important speech at the celebration of the centenary of the founding of the Communist Party of China (CPC). At the symposium on cultural inheritance and development, General Secretary of the Supreme Leader profoundly explained the great significance and important connotation of combining the basic principles of Marxism with Chinese excellent traditional culture from five aspects, emphasizing "‘ The second combination ’ It is another ideological emancipation that allows us to make full use of the valuable resources of Chinese excellent traditional culture in a broader cultural space and explore future-oriented theoretical and institutional innovations. " The "second combination" is our party’s profound summary of the historical experience of the modernization of Marxism in China, and a profound grasp of the law of the development of Chinese civilization, indicating that our party’s understanding of China’s road, theory and system has reached a new height, indicating that our party’s historical self-confidence and cultural self-confidence have reached a new height.It shows that our party’s consciousness of promoting cultural innovation in inheriting Chinese excellent traditional culture has reached a new height.

　　Since the 18th National Congress of the Communist Party of China, our Party has persisted in taking Marxism as the guidance, emancipating the mind, seeking truth from facts, keeping pace with the times, seeking truth and being pragmatic, constantly answering China’s questions, the questions of the world, the questions of the people and the questions of the times scientifically, making correct answers that conform to the reality of China and the requirements of the times, drawing scientific understanding that conforms to objective laws, forming theoretical achievements that keep pace with the times, and better guiding China’s practice; Our party insists on making the past serve the present, bringing forth the new, upholding the integrity and respecting the past and not restoring the past, linking the essence of Marxism with the essence of Chinese excellent traditional culture, and integrating it with the common values that the people are unaware of every day, endowing Chinese civilization with modern strength by Chinese modernization, endowing Chinese modernization with profound details, promoting the creative transformation and innovative development of Chinese excellent traditional culture, and achieving a series of major achievements and important experiences. Chinese excellent traditional culture and Chinese modern civilization have achieved unprecedented brand-new results. The "two combinations" consolidated the cultural subjectivity of the Chinese nation, and the creation of the Supreme Leader’s New Era Socialism with Chinese characteristics Thought is the most powerful embodiment of this cultural subjectivity.

　　Strengthen cultural self-confidence and enhance the spiritual strength of the great rejuvenation of the Chinese nation.

　　Our party has always attached importance to the strategic significance of cultural construction in realizing the great rejuvenation of the Chinese nation. Since the 18th National Congress of the Communist Party of China, the General Secretary of the Supreme Leader has scientifically explained the essence of culture based on the unprecedented great changes in the world and the overall situation of the great rejuvenation strategy of the Chinese nation, put forward that cultural self-confidence is "more basic, broader and deeper self-confidence", profoundly discussed the essence of Socialism with Chinese characteristics culture and its significance for realizing the great rejuvenation of the Chinese nation, and pointed out the new historical orientation and new cultural mission of cultural construction in the new era.

　　General Secretary of the Supreme Leader pointed out: "Culture is the soul of a country and a nation", "To strengthen Socialism with Chinese characteristics’s road confidence, theoretical confidence and institutional confidence, in the final analysis, it is necessary to strengthen cultural self-confidence", "Socialism with Chinese characteristics culture accumulates the deepest spiritual pursuit of the Chinese nation, represents the unique spiritual identity of the Chinese nation, and is a powerful spiritual force for Chinese people to March forward triumphantly", "Realizing the Chinese dream is the development process of material civilization and spiritual civilization fly with me" and "Without the prosperity of Chinese culture, there would be no Chinese. General Secretary Supreme Leader’s important exposition enriches Socialism with Chinese characteristics’s cultural development concept, broadens the road of Socialism with Chinese characteristics’s cultural development, and deepens the understanding of the law of Socialism with Chinese characteristics’s cultural construction, which is a concentrated expression of our party’s strong cultural responsibility and high cultural self-confidence.

　　Adhere to the fundamental system of Marxism’s guiding position in the ideological field and consolidate the common ideological foundation of the United struggle of the whole party and the people of the whole country.

　　Marxism is the fundamental guiding ideology of building the party and building the country, rejuvenating the party and rejuvenating the country, and is the soul and banner of our party. General Secretary of the Supreme Leader pointed out: "Marxism is the root of the towering tree of the continuous development of the cause of our party and people, and it is the source of the long river of Wan Li where our party and people keep forging ahead." "On the fundamental issue of adhering to the guidance of Marxism, we must be firm and unshakable at any time and under any circumstances." History and practice show that the fundamental system of adhering to the guiding position of Marxism in the ideological field is an important support of Socialism with Chinese characteristics’s system, an essential requirement of upholding and strengthening the overall leadership of the Party, and a powerful guarantee for developing advanced socialist culture.

　　System construction is overall, stable and long-term. To ensure that the guiding position of Marxism is reflected in the various undertakings of the party and the state, and to play the leading role of Marxism in social ideology requires strong institutional support and reliable institutional guarantee. The Decision of the Central Committee of the Communist Party of China on Upholding and Perfecting the Socialism with Chinese characteristics System and Promoting the Modernization of the National Governance System and Governance Capacity, which was deliberated and adopted by the Fourth Plenary Session of the 19th CPC Central Committee, emphasized the fundamental system of upholding the guiding position of Marxism in the ideological field, and made a series of major arrangements, clearly put forward and improved the work system of arming the whole party and educating the people with the Party’s innovative theory, improved the learning system at all levels such as the theoretical learning center group of the Party committee (party group), established the system and mechanism of educating people in a full, full and all-round way, and implemented the ideology. This is of great significance for building a socialist ideology with strong cohesion and leading power and consolidating the common ideological foundation of the United struggle of the whole party and the people of the whole country.

　　Adhere to and strengthen the party’s overall leadership over ideological work, and firmly grasp the leadership, management and discourse power of ideological work.

　　Ideological work is an important aspect of cultural construction. Whether ideological work can be done well is related to the future and destiny of the party, the long-term stability of the country, national cohesion and centripetal force. Since the 18th National Congress of the Communist Party of China, the General Secretary of the Supreme Leader has placed ideological work at the height of the overall strategic situation, emphasized that "ideological work is the work of building the heart for the country and the soul for the nation", put forward a series of new ideas, new viewpoints and new theories, made a series of major arrangements, made efforts in various ways to solve the outstanding problems, and adopted various methods to effectively reverse the passive situation that once appeared in the ideological field.

　　General Secretary of the Supreme Leader asked the whole Party to fully understand the complexity and long-term nature of ideological struggle, enhance the position consciousness, strengthen the position construction, and firmly grasp the leadership, management and discourse power of ideological work. The General Secretary of the Supreme Leader profoundly pointed out: "Propaganda and ideological positions, if we don’t occupy them, others will occupy them." General Secretary of the Supreme Leader stressed: "All propaganda and ideological departments and units, party member and cadres on the propaganda and ideological front must adhere to the principle of party spirit in a clear-cut manner." "The core of adhering to party spirit is to adhere to the correct political direction, stand firm in political stance, firmly publicize the party’s theory, line, principles and policies, firmly publicize the major work arrangements of the central government, firmly publicize the central government’s major analysis and judgment on the situation, resolutely maintain a high degree of consistency with the CPC Central Committee, and resolutely safeguard the central authority." Wall-riding school ’ And ‘ See the wind school ’ You can’t cherish feathers. Comrades on the propaganda and ideological front should fulfill their sacred duties and glorious missions, and actively participate in the front line of propaganda and ideological struggle with the attitude of fighting and the responsibility of soldiers. " In the decade of the new era, under the strong leadership of the CPC Central Committee with the Supreme Leader as the core, the ideological situation in China has undergone an overall and fundamental change, and the cultural self-confidence of the whole party and the people of all ethnic groups has been significantly enhanced.The cohesion and centripetal force of the whole society have greatly improved, providing a strong ideological guarantee and strong spiritual strength for the new era to create a new situation in the cause of the party and the state.

　　Cultivate and practice socialist core values and improve the ideological and moral level of the whole nation.

　　General Secretary of the Supreme Leader pointed out: "For a nation and a country, the most lasting and deepest strength is the core values recognized by the whole society. Core values bear the spiritual pursuit of a nation and a country, and embody a value standard for judging the merits of a society. Cultivating and carrying forward core values and effectively integrating social consciousness are important ways for the normal operation of social systems and the effective maintenance of social order, and are also important aspects of national governance system and governance capacity. History and reality show that core values are an important stabilizer for a country, and whether they can be constructed with strong appeal is related to social harmony. To strengthen cultural self-confidence, carry forward the spirit of China, highlight China’s values and unite China’s strength, we must vigorously cultivate and practice socialist core values, take cultivating and carrying forward socialist core values as a basic project to gather spirits and strengthen the foundation, constantly consolidate the ideological and moral foundation of Socialism with Chinese characteristics and improve the ideological and moral level of the whole nation.

　　General Secretary of the Supreme Leader pointed out: "Chinese civilization stretches for thousands of years and has its unique value system." "We advocate and carry forward socialist core values, and we must draw rich nutrition from them, otherwise it will not have vitality and influence." This profoundly enlightens us that the cultivation and promotion of socialist core values must be based on Chinese excellent traditional culture. The firm core values have their inherent roots. Abandoning tradition and losing the roots is tantamount to cutting off one’s spiritual lifeline. In the new era and new journey, in order to build the modern civilization of the Chinese nation, we should cultivate and practice the socialist core values, seriously absorb the ideological essence and moral essence of Chinese excellent traditional culture, deeply explore and expound the times values of Chinese excellent traditional culture, such as caring, attaching importance to the people, keeping honesty, worshiping justice, respecting harmony and seeking harmony, and inheriting and carrying forward them in light of the new times conditions, so as to make them an important source of cultivating socialist core values.

　　(The author is a professor at the School of Marxism, Renmin University of China)

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Hubei： Ecological Priority, Green Development, Firmly Stand Up the ＂Waist of the Yangtze River＂

　　The finless porpoise swims in the old course of the Yangtze River in Swan Island, Hubei Province. Photo by Niu Yibin

　　On the sparkling Wuhan section of the Yangtze River, finless porpoises are in groups of three or five, chasing for food and swimming in the river in early spring. The finless porpoise has high requirements on the water environment and is known as the "giant panda in the water". After the implementation of the great protection strategy of the Yangtze River, with the improvement of water quality and the increase of fish, the once rare finless porpoise has gradually increased.

　　"The Yangtze River Economic Belt should embark on a new path of ecological priority and green development." Four years ago, General Secretary of the Supreme Leader gave directions and drew a blueprint for the development of the Yangtze River Economic Belt under the new situation in Hubei.

　　Sitting on the longest runoff mileage of the Yangtze River trunk line, Hubei is called the "waist of the Yangtze River" and shoulders the important mission of ensuring that "one reservoir of clear water is sent to the north and one reservoir of Qing Jiang water flows to the east". Jingchu earth keeps in mind the general secretary’s earnest entrustment, makes great efforts to further promote the high-quality development of the Yangtze River Economic Belt, and writes Hubei answer sheet.

　　Based on ecological protection, the face has taken on a new look.

　　River view of Tianxingzhou Yangtze River Bridge in Wuhan. Photo courtesy of Wuhan Water Affairs Bureau

　　Wuhan Hongshan River Beach starts from Baishazhou Bridge in the west and ends at Yangsigang Bridge in the east, with a total length of 3.12 kilometers, which is the "final work" of the river beach construction in the central city of Wuhan.

　　"The river beach here is so beautiful!" Ms. Zhang, who lives in Baishazhou, is playing in the park with her 9-year-old daughter. "It used to be a wasteland, but now it has a new look, and everyone says yes."

　　After years of transformation, Wuhan Jiangtan has changed from a flood control beach to a baili gallery. The quiet Hankou River Beach, the romantic and warm Hongshan River Beach, the simple and simple Wuchang River Beach, the winding Hanyang River Beach and the picturesque Qingshan River Beach have become the ecological waterfront paradise of Jiangcheng people.

　　Looking back more than 600 kilometers to the upper reaches of the Yangtze River, the same gratifying changes also took place in Yichang. In spring, the warm sun spreads all over the earth, overlooking the Yangtze River Bridge in Wujiagang, Yichang. The vegetation on both sides is lush, the trees and flowers are scattered, and the boats on the green river are busy. Under the North Shore Bridge, the Yichang Yangtze River shoreline renovation and restoration project is about to open to the public. After the completion of the project, the Yangtze River coastline will add new beauty — — Yichang Dongdaemun Ecological Corridor.

　　Behind the "green clothes" on the coastline of the Yangtze River, it is inseparable from the all-out cracking of "chemical encircling the river" and the thunder rectification of illegal docks.

　　On April 19, 2022, it was photographed on the coastline of the Yangtze River, 8 kilometers away from Xiaoting District, Yichang City, Hubei Province. After the completion, the revetment along the river in Xiaoting District was picturesque. Photo courtesy of Propaganda Department of Yichang Municipal Committee

　　In 2017, Yichang City took the lead in starting the customs clearance, modification, relocation and transfer of 134 chemical enterprises within 1 km along the Yangtze River. Hubei Xingfa Group, which is good at fine phosphorus chemical industry, resolutely started the relocation of 70,000 tons of glyphosate and glycine plant in Linjiang Park. In the process of relocation, it implemented transformation and upgrading, and cultivated electronic chemicals and new materials from silicone. The economic benefits increased instead of falling.

　　At the port of Libu, Jingzhou, it is the peak period of port freight, and several cranes are unloading sand and gravel. The blue fully enclosed belt conveyor corridor, like two tentacles, extends from the storage yard to the river bank, realizing that "sand and gravel don’t fall to the ground, and sand can’t be transported". This "air transportation corridor" can not only collect sand and gravel, but also receive ship garbage.

　　Just a few years ago, there were 40 gravel docks and more than 20 building materials enterprises along the coastline where Libo Port was located. In order to solve the problem of small, scattered and chaotic gravel docks, Jingzhou City has built a gravel collection center, which makes "a sunny day covered with dust and a rainy day covered with mud" completely a thing of the past.

　　At present, the Jingzhou section of the Yangtze River, which is 483 kilometers long, is full of beautiful scenery. The ecological green corridor meanders along the river, and it is "beaded into a chain" with the Wenchuang Garden, Wanshou Park and Yangtze River Bridge at the ocean pier, showing "the Yangtze River is thousands of miles long and the beauty is in Jingjiang".

　　"Man and water struggle" has become "man and water depend on each other", and the change of the word difference shows the beauty of the Yangtze River after ecological improvement.

　　Taking the top ten landmark "campaigns" of the Great Protection of the Yangtze River as the starting point, the trunk line of the Yangtze River in Hubei Province banned 1211 illegal docks, vacated 149.8 kilometers of coastline, and restored 8.56 million square meters of ecology; By the end of last year, 5,186 of the 12,480 sewage outlets in Hubei section of the Yangtze River had been rectified, and the water quality in Hubei section of the main stream of the Yangtze River had been stable at Class II standard for two consecutive years. A beautiful picture of the Yangtze River is slowly unfolding.

　　Green development is the way to promote modernization

　　Luoshan Town, honghu city is bordered by the Yangtze River in the south and the Baili Honghu Lake in the north. The local people have made the lake their home and fishing for generations, and Yu Zhimu is one of the millions of fishermen in Honghu Lake.

　　Since 1996, Yu Zhimin has covered more than 2,000 mu of water in Honghu Lake area for purse seine farming. Under the strategy of "protecting the Yangtze River together and not developing it", Yu Zhimin, who has dealt with "fishing" all his life, bid farewell to the stormy water life with the fishermen in the same village and moved from the lake to the shore to continue raising crabs. Today, Honghu base, an old fisherman in charge, has become a demonstration base for localized cultivation of crab fry in Hubei Province.

　　Not being unemployed when landing, all the 31,952 fishermen who need to change jobs have completed their jobs and taken up "new rice bowls".

　　Driven by the transformation and upgrading, the city has also ushered in great changes.

　　"Asia’s first tiankeng" in Huangshi National Mine Park, Hubei Province. Photo by Wang Guozhen

　　Huangshi, which is prosperous because of mines, is a traditional old industrial base that relies on resources. It has long relied on steel, coal and non-ferrous metals to support the industrial structure. Nowadays, the local government has inserted the wings of "technological transformation of 100 enterprises" to legislate for mine restoration, and "whoever develops will protect and whoever destroys will govern", forcing mining rights holders to implement ecological restoration and let old industrial bases open new branches and sprout.

　　The former location of Daye Iron Mine has now been transformed into a 4A-level tourist attraction Huangshi National Mine Park, and it has been listed as a "National Industrial Heritage Tourism Base", receiving more than 300,000 tourists every year.

　　The conversion of old and new kinetic energy is accelerated, and "low carbon" has become a new trend of green life.

　　Early in the morning, Li Ruyin carried a hoe and took several fellow villagers to the mountains to weed and protect bamboo forests. He is not only a villager in Jinkeng Village, Yanxia Township, Tongshan County, Xianning City, but also the "Lin Chang" of Nanzhu Base. "Can’t rest a day! I want to protect my ‘ Cash cow ’ 。” Li Ruyin said with a smile, "It is not a small sum to earn 50 yuan per mu a year. With bamboo, my annual income has doubled. "

　　The "cash cow" in Li Ruyin’s mouth is a 3,000-mu bamboo forest planted in barren hills, which is part of the carbon sink project of bamboo afforestation in Tongshan County. "Relying on bamboo forests to absorb carbon and spit oxygen, this project can absorb 6,500 tons of carbon dioxide every year. Those enterprises whose carbon emissions exceed the standard can purchase our emission reductions through Hubei Carbon Emissions Trading Center. " Li Ruhuo, one of the project investors and chairman of Tongshan Ruhuo Agricultural Science and Technology Development Co., Ltd. said.

　　A small bamboo, one end is connected with energy conservation and emission reduction, and the other end is connected with rural revitalization. Tongshan people like Li Ruyin are happy to "sell ‘ Carbon ’ Weng ". Today, there are more than 400,000 mu of bamboo carbon sequestration projects in Tongshan County, which has increased the income of more than 30,000 farmers and created a new way to get rich.

　　By the end of December 2021, the carbon market quota in Hubei had reached 365 million tons, with a total turnover of 8.651 billion yuan.

　　Scientific and technological innovation as the source to maintain vitality forever

　　"Yangtze Three Gorges 1" is a new energy pure electric ship with the largest power battery capacity and the most advanced intelligence designed and built in the world. Photo courtesy of Propaganda Department of Yichang Municipal Committee

　　At 9 o’clock in the morning of March 29th, with a loud whistle, the pure electric tourist passenger ship with the largest electricity load in the world — — "Three Gorges on the Yangtze River No.1" made its maiden voyage at Zigui Xingang Wharf in Yichang City.

　　Compared with the traditional power cruise ship, "Yangtze Three Gorges 1" is driven by clean hydropower, which can replace about 530 tons of fuel oil every year and reduce harmful gas emissions by more than 1,600 tons. After it is put into operation, it will provide new experiences for tourists and serve the green and high-quality development of the Yangtze River Economic Belt.

　　On April 8, the container port area of Wuhan Yangluo Port was even more magnificent in the afterglow of the sunset. Foreign trade containers equipped with masks, non-woven fabrics and other medical supplies will sail directly to Japan from here.

　　Thanks to the technical upgrading of the system and the integrated operation of the first, second and third phases of the port area, the annual container throughput of Yangluo Port has increased from 760,000 TEUs in 2013 to 2.48 million TEUs last year. According to statistics, the average waiting time of ships in Yangluo Port has been reduced by 12 hours, the working efficiency of the wharf has been improved by 30%, and the golden waterway has truly achieved golden benefits.

　　At present, relying on Yangluo Port, Hubei connects the "Belt and Road" with the Yangtze River Economic Belt by multi-channel multimodal transport, and builds a Wuhan port-type national logistics hub that connects things, radiates the whole country and connects the international community. In the first quarter of this year, the shipment volume of China-Europe train (Changjiang) increased by 60% compared with the same period of last year. By the end of the 14th Five-Year Plan, the port cargo throughput in Hubei Province is expected to reach 250 million tons, and the container throughput will strive to reach 5 million TEUs.

　　Wuhan Yangluo Port in the Afterglow of Sunset. Zhou Wei

　　On the bank of the Yangtze River, a number of strategic emerging enterprises are gestating and growing, and trillions of industrial clusters such as "optical core screen end network", big health and automobile manufacturing are accelerating.

　　Wuhan East Lake High-tech Zone is full of innovation. This is the first batch of national high-tech zones and the Wuhan area of China (Hubei) Pilot Free Trade Zone, and it has been approved as a national optoelectronic information industry base, a national bio-industry base and a national storage base, also known as "China Optical Valley".

　　At present, Hubei leads the development of emerging industries with innovation drive, and accelerates the establishment of Wuhan’s nationally influential science and technology innovation center and East Lake comprehensive national science center; There are 30 national key laboratories in the province, ranking fourth in the country in total, and there are nearly 15,000 high-tech enterprises … …

　　The Yangtze River is long and the clear water is full; The sound of entrustment is inspiring. Jingchu Land is faithfully implementing the decision-making arrangements of the CPC Central Committee on the development of the Yangtze River Economic Belt, maintaining historical patience and strategic determination, carrying out a blueprint to the end, and writing a new chapter in Hubei’s high-quality development.

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Hubei： Ecological Priority, Green Development, Firmly Stand Up the ＂Waist of the Yangtze River＂

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